DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP15B and ADAP1

DIOPT Version :9

Sequence 1:	NP_573183.2	Gene:	RhoGAP15B / 32686	FlyBaseID:	FBgn0030808	Length:	1552	Species:	Drosophila melanogaster
Sequence 2:	NP_001271237.1	Gene:	ADAP1 / 11033	HGNCID:	16486	Length:	385	Species:	Homo sapiens

Alignment Length:	250	Identity:	50/250 - (20%)
Similarity:	78/250 - (31%)	Gaps:	95/250 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   289 AGRSLKHASKRFG----SNFSLGRNKDKADIGIGGRPGGSGEMDLDRRQTMPSTEVFNTIQFSSP 349
            |.|..|...|..|    .:.||||:.|.|...:|                     ||..:..|.
Human    15 ARRKWKEFEKMLGCAEEGHASLGRDPDWASYTLG---------------------VFICLSCSG- 57

  Fly   350 LNRNGGLPDLRENDAKLQKEDYLRPDPDQE----------DDGCYEVPKTQGKPPSYDEALRSRP 404
                     :..|..::.|...:|.|..:|          :|...  .:.:.|.||:    ..||
Human    58 ---------IHRNIPQVSKVKSVRLDAWEEAQVEFMASHGNDAAR--ARFESKVPSF----YYRP 107

  Fly   405 SPSDSPMSRNLAQEAAQLVQLRNQRQLSSSSSNGDESPRLPMPAFPPPRLSQQPEQFRMDALQPP 469
            :|||..:.|.      |.::.:.:||                             :|.....|.|
Human   108 TPSDCQLLRE------QWIRAKYERQ-----------------------------EFIYPEKQEP 137

  Fly   470 VRQKRRKNYEHIELRRPPVDSAQLEELNRAAAAAEREESLLISAKNAEAETKTPK 524
            .....|:.:    |.:...|:.|.  |:|.....|||.:|....:|   :.|.||
Human   138 YSAGYREGF----LWKRGRDNGQF--LSRKFVLTEREGALKYFNRN---DAKEPK 183

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP15B	NP_573183.2	RhoGAP_ARAP	1095..1277	CDD:239850
ADAP1	NP_001271237.1	ArfGap	28..137	CDD:214518	30/180 (17%)
		PH1_ADAP	141..249	CDD:270072	13/51 (25%)
		PH	142..239	CDD:278594	13/50 (26%)
		PH2_ADAP	263..368	CDD:241282
		PH	266..366	CDD:278594
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900