DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGAP15B and Arap3

DIOPT Version :9

Sequence 1:	NP_573183.2	Gene:	RhoGAP15B / 32686	FlyBaseID:	FBgn0030808	Length:	1552	Species:	Drosophila melanogaster
Sequence 2:	XP_006525549.1	Gene:	Arap3 / 106952	MGIID:	2147274	Length:	1539	Species:	Mus musculus

Alignment Length:	1648	Identity:	334/1648 - (20%)
Similarity:	548/1648 - (33%)	Gaps:	571/1648 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 SNNINHNNIKKLNINAENLHGNCAEKKLPSSGQNKLILQENNSDSQQPIYGPDAN-ENVQEPVYA 97
            :.::.|..::.|.|:|              :|..|.||:...:.|.:...  |:: :|..||
Mouse    36 AQHLGHEELRHLGISA--------------TGHRKRILRLLRAGSAEGFL--DSHLDNTMEP--- 81

  Fly    98 TPRPAPRQRLPPAGEPEDSYPDPDDEVPLRILRAAPQIPPKPLNILLDQRSSICSEVSTTSVQTP 162
            ||.|||           |:.|              |:..|||        .::....:..:.|.|
Mouse    82 TPSPAP-----------DAQP--------------PKPVPKP--------RTVFGLSNPATAQRP 113

  Fly   163 GKAD--EDREGSRYASNASLDCSESSHSGKFKSQSPGYVDAVDSSIPQSDHPDPNGHHPQAESSS 225
            |.:.  .|.|.||     :.:|::.|        ||        .:|                ||
Mouse   114 GLSPIFWDPEVSR-----NSECTQRS--------SP--------LLP----------------SS 141

  Fly   226 AEQSSGSQDGDDDNNLLRSLGTTSKLLGEAIGERITFKAKGAKKRLDRNFKSSTEAISNIGADAG 290
            :||.              |:..|.:::..||
Mouse   142 SEQP--------------SVPNTMEMMPNAI---------------------------------- 158

  Fly   291 RSLKHASKRFGSNFSLGRNKDKADIGIGGRPGGSGEMDLDRRQTMPSTEVF----NTIQFSSPLN 351
                    .||             :.:.||...:.::..|..|....|..|    .|:....|
Mouse   159 --------YFG-------------LDLRGRAQAAQDVTPDSSQATVPTPAFRPTTGTVHIMDP-- 200

  Fly   352 RNG---------GLP---DLRENDAKLQ-KEDYLRPDPDQEDDGCY---EVP-------KTQGKP 393
              |         |:|   |.|:.....| :.::.|.|.:..:|..|   |:|       .||...
Mouse   201 --GCLYYGVQPVGIPGASDRRDGRGVCQERAEHSRQDLETREDAGYASLELPGDSILSLPTQDAE 263

  Fly   394 PSYD--------EALRSRPSPSDSPMSRNLAQEAAQLVQLR----NQRQLSSSSSNGDESPR--L 444
            .|.|        .:...||.|..|.....|:.:...:.|.|    |.|.|....|:.|..|:  :
Mouse   264 TSDDLISPYASFSSTADRPVPLLSGWLDKLSPQGNYVFQRRFVQFNGRSLMYFGSDKDPFPKGVI 328

  Fly   445 PMPAFPPPRLS----------QQPEQFRMDA----------LQPPVRQKRRKNYEHIELRRPPVD 489
            |:.|....|.|          |:...||.::          ||..::::|...:.     |||
Mouse   329 PLTAIEMTRSSKDNKFQVITGQRVFVFRTESEAQRDLWCSTLQSCLKEQRLLGHP-----RPP-- 386

  Fly   490 SAQLEELNRAAAAAEREESLLISAKNAEAETKTPKPERSDSWEFYGEDENEEEDRDEEQEGSSSP 554
                                           ..|:|.|:.:.|..|..
Mouse   387 -------------------------------HPPRPLRTGTLELRGHK----------------- 403

  Fly   555 EPLYANQEATYGKLFEMATAGSSRSNVLTPNQVA---EQQQLA-----CITEDSELDACEGAVGG 611
                       .|:|.          .|.|.::|   .:|..:     |..   ||..|.
Mouse   404 -----------AKVFA----------ALIPGELALYKSEQAFSLGIGICFI---ELQGCS----- 439

  Fly   612 VPLPQAVIEEFDPLSSKCSTLARSNKSNEL-LLLEHLLEEDTYGTVKAEQDDVSMCTSEEEPTTS 675
                                 .|..||... ||..|.....|..:..|.|   |...:.:|..|.
Mouse   440 ---------------------VRETKSRSFDLLTPHRCFSFTAESGGARQ---SWAAALQEAVTE 480

  Fly   676 AATSPKPQQPQIVHQNARLLSDSMENMLDSDQERAKP---------YLSRMPESANKA--SGPVD 729
            ..:.         ::.|..:..:..|...:|...::|         .:.:.....::|  ||...
Mouse   481 TLSD---------YEVAEKVWSNPANRHCADCRASRPDWAAVNLGVVICKQCAGQHRALGSGISK 536

  Fly   730 LASASRNRTNW-------FV---PDKASCSDVTPNTSKTTPPIEGDSPPTYLEAIGGSKDAAGNQ 784
            :.|...:.:.|       |:   .|:|:|.     .:...||.||..|           |:|...
Mouse   537 VQSLKLDTSVWSNEIVQLFIVLGNDRANCF-----WAGALPPGEGLHP-----------DSAPGP 585

  Fly   785 ENRSTIGSRFRQTINAISNVKLKMDAMKRKASFRGANQRQSDVRVALQMVPRPSLSPLLIR---- 845
              |....||           |.|:      ..||..:.|..|....||.:......|.|::
Mouse   586 --RGEFISR-----------KYKL------GLFRKPHPRHPDHSQLLQALCAAMAGPNLLKNMAQ 631

  Fly   846 ------YEGPLVRFPSGVVEDILKEMQN-----RKAILRERQFQTFL-----DQEMKTPREMIPL 894
                  .||.....||.:...:|..:.:     ...::....::.||     ..:...|    ||
Mouse   632 LLCVETSEGEEPLSPSALNGSLLSLLPSDSPGVYNEVVVPATYRGFLYCGSISNKAGAP----PL 692

  Fly   895 ----DTITTLQCVSNSRVTDTATH-------------FYCFEITTSQPKNGNGAGDAMSSNPNLL 942
                |....|.||..:.:...|:.             ..|..:  |.|....|..|....:..|:
Mouse   693 RRGRDAPPRLWCVLGAALEMFASESSPEPLSLLQPQDIVCLGV--SPPPADPGDLDRFPFSFELI 755

  Fly   943 MTSSSSGNVKQQRVSHLYGVGKESER------GVWMQKILESLTNSLPVKYTCH------YYRAG 995
            :|..        |:.|....|.:|..      |.|...:            :||      ..|.|
Mouse   756 LTGG--------RIQHFATDGADSLEAWISAVGKWFSPL------------SCHQLLGPGLLRMG 800

  Fly   996 WCYLKN-SITSEWSGTWL----VLRKSQRRLIFVSEANG-----NVEKMDLRKARCI-VLKESDE 1049
            ..:|:: |......|.||    :||...   :|:..|.|     ..:.:.||:.:.| |:..:|.
Mouse   801 RLWLRSPSHAGLAPGLWLSGFGLLRGDH---LFLCPAPGPGPPAPEDMVHLRRLQEISVVSAADT 862

  Fly  1050 SIDNLH---VESGPMLMIDCPPYAVYMIMSSARETKIWRHIIREVAHNNGFSLGDQQLTRYDVPV 1111
            .....|   ||:|..|         |:......:...|...|...|...|..|.:||::|.|:|:
Mouse   863 PDKKEHLVLVETGRTL---------YLQGEGRLDFAAWNTAIGGAAGGGGTGLQEQQMSRGDIPI 918

  Fly  1112 IVDKCINFVYIHGSMSEGIYRKSGSENSMHKLMSAFRADAFNVEITRNEYNEHDVANVLKRFMRD 1176
            |||.||:||..||...||:|||.|:.....:|::.||.||.:|::...|:...||.:.||||.|:
Mouse   919 IVDACISFVTQHGLRLEGVYRKGGARARSLRLLAEFRRDARSVKLRPREHFVEDVTDTLKRFFRE 983

  Fly  1177 LPE-----RLLGKLTDSFVFVTELAVASEKIPIYRELLARLSAIERETLRRIVGHLVFISSQQAK 1236
            |.:     |||.:..::    .||:..::::..|:|:::.|..:.|.||..::|||..:....:.
Mouse   984 LDDPVTSARLLPRWREA----AELSQKNQRLEKYKEVISCLPRVNRRTLATLIGHLYRVQKCASL 1044

  Fly  1237 NKMSVQNLTMIWGPTLLAKKSDELIYSQKEADVLSDLVVLYKNLFPCSAD---EIKREQAMLACL 1298
            |:|..:||.:::.|::.....    ..:.|..||.:|:..|.::|...:|   :|..|.:::.
Mouse  1045 NQMCTRNLALLFAPSVFQTDG----RGEHEVRVLQELIDGYISVFDIDSDQAAQIDLEVSLIT-- 1103

  Fly  1299 QKYYAAAETLKDA-VKQSGDIKIWISLNPN-PENKTEEKTQVNATISPTKTAYELCREYSAKMQ- 1360
                    |.||. :.|:||:.:.:.:... |:|      .|...:|||.||.||..:. .:|:
Mouse  1104 --------TWKDVQLSQAGDLIMEVYIEQQLPDN------CVTLKVSPTLTAEELTNQV-LEMRG 1153

  Fly  1361 --LPTHQLTLYEVILNDSLERPLHHDTKVFDVILNWSYWPEEDRKHNYLVVRPVEML-------- 1415
              ..|.....:|::.:..||||||...||.:..|.|...||.....  |::|.|.|.
Mouse  1154 AASGTDLWVTFEILEHGELERPLHPKEKVLEQALQWCQLPEPCSAS--LLLRKVSMAHAGCLFTG 1216

  Fly  1416 --REIQRAVKNLATVTPGKEL--RFADSRTKTFKTLQCELRDGKIVVSKKDKNDKTTIVREIFLQ 1476
              ||..|.........|.:.|  ||.:   :.|.     :|...:::.|:.|:.|..  ||..|:
Mouse  1217 VRRESPRVGLLRCREEPPRLLGNRFQE---RFFL-----VRGRCLLLLKEKKSSKPE--REWSLE 1271

  Fly  1477 SSTAYLGCERKRDFPWSWAITFV 1499
            .:..|||..:|...|..|..|.:
Mouse  1272 GAKVYLGIRKKLKPPTLWGFTLI 1294

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP15B	NP_573183.2	RhoGAP_ARAP	1095..1277	CDD:239850	60/186 (32%)
Arap3	XP_006525549.1	SAM_Arap1,2,3	4..66	CDD:188889	8/43 (19%)
		PHA03247	<81..312	CDD:223021	66/376 (18%)
		PH1_ARAP	285..377	CDD:270073	19/91 (21%)
		PH2_ARAP	392..475	CDD:270074	23/152 (15%)
		ArfGap_ARAP3	485..600	CDD:350089	25/149 (17%)
		PH-like	671..783	CDD:388408	22/125 (18%)
		PH-like	798..891	CDD:388408	23/104 (22%)
		RhoGAP_ARAP	906..1081	CDD:239850	59/182 (32%)
		Ubiquitin_like_fold	1113..1210	CDD:391949	31/105 (30%)
		PH5_ARAP	1210..1326	CDD:270079	22/95 (23%)
		PLN02983	<1472..>1538	CDD:215533
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	104	1.000	Domainoid score	I6683
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S6020
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001278
OrthoInspector	1	1.000	-	-		otm44184
orthoMCL	1	0.900	-	-		OOG6_104434
Panther	1	1.100	-	-	O	PTHR45899
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3385
SonicParanoid	1	1.000	-	-		X1129
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.840