Protein Alignment RhoGAP15B and arap2

DIOPT Version :9

• Sequence 1: NP_573183.2
• Gene: RhoGAP15B / 32686
• FlyBaseID: FBgn0030808
• Length: 1552
• Species: Drosophila melanogaster
• Sequence 2: XP_031751219.1
• Gene: arap2 / 100494395
• XenbaseID: XB-GENE-991948
• Length: 1566
• Species: Xenopus tropicalis
• Alignment Length: 1506
• Identity: 303/1506 - (20%)
• Similarity: 555/1506 - (36%)
• Gaps: 380/1506 - (25%)

  Fly   238 DNNLLRSLGTTSKLLGEAIGERITFKAKGAKKRLDRNFKSSTEAISNIGADAGRSLKHASKRFGS 302
            ::.:|:.:|.:  |.|..  :||..|.:..::::.|..::|....|:  ::...|:.|.||...:
 Frog    45 NHEILQEMGIS--LTGHR--KRIIAKLQSIQEQMRRESRNSDSLTSD--SELQNSITHGSKPLDT 103

  Fly   303 NFSLGRNKDKADIGIGGRPGGSGEMDLDRRQTMPSTEVFN--TIQFSSPLNRNGGLPDLRENDAK 365
            ...:......:.:.....|..|           ||.|..|  |.|:....:.|........|:..
 Frog   104 ILPVSEQVQGSTMEYNASPDSS-----------PSKEADNNSTCQYQQKEDSNDQFNRTGLNEKS 157

  Fly   366 LQKEDY--------LRPDPDQEDDG------------CYEVPKTQG------KPPSYDEALRSRP 404
            |:.:|:        |....|.::.|            .|:..|..|      .||:....||:||
 Frog   158 LEIKDHSVKDFPLDLETQLDSQNSGFFEFQGPMVDNEIYDKSKDDGHKPLLKSPPTKSFILRNRP 222

  Fly   405 SP------SDS-----PMSRNLAQEAAQLVQLRNQRQLSSSSSNGDESPRLPMPAFPPPR----- 453
            .|      ||:     ...|.|..:|||        :.|:|.....||....:....|..
 Frog   223 VPKLPFNTSDTFVKSCHQERRLENKAAQ--------ESSASKQQNQESQEQNINLISPYEETFFS 279

  Fly   454 LSQQPEQFRMDALQ-PPVRQKRRKNYE----------HIELRRPPVDSAQLEELNRAAAAAEREE 507
            .|:.|::...|..| |...::..|:.|          ......||....|:.           ||
 Frog   280 NSEFPKETSRDKFQFPSYHEQNEKSLEKNASTSCGSLSANNGSPPPPGDQIS-----------EE 333

  Fly   508 SLLISAKNAEAETK-------TPKPERSDSWEFYGEDENEEEDRDEEQEGSSSPEPLYANQEATY 565
            |:..:.:....|.:       ||.|..|         .:.:.....|.||:.|....||   ..|
 Frog   334 SIYSTMEECTRELRVNRGIGMTPDPAAS---------LHTDSGTSSELEGAESEISPYA---CFY 386

  Fly   566 GKLFEMATAG------SSRSNVLTPNQV-AEQQQLACITEDSELDACEGAVGGVPLPQAVIE--- 620
            |.....|..|      ..||.:.....| .:...|:....|.::    .:.|.:.|| |:.:
 Frog   387 GPSTMPAKTGWLEKLSPHRSGIFQKRWVKVDGMHLSYYNNDRDM----FSKGKISLP-AITKVNK 446

  Fly   621 ----EFDPLSSKCSTLARSNKSNELLLLEHLLEEDTYGTVKAEQDDVSMCTSEEEPTTSAATSPK 681
                :|:.::.:.:.:.|:.|           |||     :.:..|..:.||:.||.
 Frog   447 MGESKFEVVTVQRTFVFRTEK-----------EED-----RDDWIDTLLRTSKSEPY-------- 487

  Fly   682 PQQPQ--IVHQNARLLSDSMENMLDSDQERAKPYLSRMPESANKASGPVDL-------------- 730
             :.|.  :..:|..|.....:|.:.:....:|.:.|:..:.|:......||
 Frog   488 -EFPDLCVTEKNGYLELKGYKNKIYAVINGSKLWFSKSKQDASAGIAITDLTLTMVSVKIIDRKS 551

  Fly   731 -------------ASASRNRTN----------------------WFVPDKASCSDVTPNTSKTTP 760
                         |.:.|.:..                      ||.....||:|
 Frog   552 FELTTPFRHFCLTAESEREKQEWTEEIQQSIAETLADYEVAEKIWFNESNRSCAD---------- 606

  Fly   761 PIEGDSPPTYLEAIGG--SKDAAGNQENRSTIGSRFRQTINAISNVKLKMDAMKRKASFRGANQR 823
             ....||.....::|.  .|:.||...   .:||...:..:.|.:..:..:.:.......| |::
 Frog   607 -CRAPSPDWASISLGVVICKNCAGQHR---ALGSNISKVHSLILDTTIWSNELVELFIVVG-NEK 666

  Fly   824 QSDVRVA-------LQMVPRPSLSPLLI--RY-EGPL--VRFPSGVVEDILKEMQNRKAILRERQ 876
            .:::..|       |.|....|...|.|  :| ||..  :.||....|::.:.:.:  |:.::..
 Frog   667 VNNIWEANLLPENMLHMDSNVSQRRLFITQKYKEGRFKKIYFPGFTQEELNQALCD--AVTKDEI 729

  Fly   877 FQTFL-------------DQEMKTPREMIPLD-TITTLQCVSNSRVTD---------TATHFYCF 918
            .||.:             |:...||..:..:. ....::.:.::|::|         .|:.|||.
 Frog   730 LQTMILVFSGADTMCPTGDKVYNTPYLLAKMSGQRLQMEFLHHNRLSDFKAPSLNANGASLFYCG 794

  Fly   919 EITTSQPKN------------------------------------GNGAGDAMSSNPNLLMTSSS 947
            .:..:.|..                                    .:|..|.......::..|..
 Frog   795 FLYKASPSTKMTINRKSKEVPEMKQWWCTIENNFLKYYENETAPVADGVIDLSEIISLVIHPSDF 859

  Fly   948 SGN----------VKQQRVSHLYGVGKESERGVWMQKILESLTNS-----LPVKYTCHYYRAGWC 997
            |.|          ...:|: .|:|......|..|.:.|.::.|.:     |.:.:..    .|:.
 Frog   860 SSNGMAAFTFEIYFLSERM-FLFGAENVESRREWSRAIAKNFTPAVEGYLLELDFNV----LGYL 919

  Fly   998 YLKNSIT-SEWSGTWLVLRKSQRRLIFVSEAN-GNVEKMDLRKARCIVLKESDESIDNLHVESGP 1060
            ..|||.: |:|...|..|.|:  ||.:.::.: ||.:.:.|:|     |:|...:...|:.|.|.
 Frog   920 NYKNSSSLSQWKKGWFALEKA--RLHYCNKDDCGNADTIQLKK-----LQELTANSSTLNGEKGN 977

  Fly  1061 MLMIDCPPYAVYMIMSSARETKIWRHIIREVAHNNGFSLGDQQLTRYDVPVIVDKCINFVYIHGS 1125
            :|::.......|:...:..:..:|...|.:.|..:|.:|.||||::.::|:||:.||.||..:|.
 Frog   978 ILLLVENGRTFYIHGHTMLDFTVWHSAIEKAAGTDGNALQDQQLSKNNIPIIVNSCIAFVTQYGL 1042

  Fly  1126 MSEGIYRKSGSENSMHKLMSAFRADAFNVEITRNEYNEHDVANVLKRFMRDLPERLLGK-LTDSF 1189
            .|:.:|.|:|:...:.:|:..|:.||.::::...::...||.:|||.|..::.:.||.| |...:
 Frog  1043 GSKSLYLKNGNPLQVRELLEEFKKDARSIKLKVGKHQLEDVTDVLKYFFYEIDDALLTKELYPYW 1107

  Fly  1190 VFVTELAVASEKIPIYRELLARLSAIERETLRRIVGHLVFISSQQAKNKMSVQNLTMIWGPTLLA 1254
            :...::....|::..|:.:::.:.|:.:.||..::.||..|......|.:..|.|...:...|..
 Frog  1108 ISALDIRNEQERVKKYKTVISTVPALNKATLAALIEHLFRIQKCFDINHLDTQTLAKAFSSCLFQ 1172

  Fly  1255 KKSDELIYSQKEADVLSDLVVLYKNLFPCSADEIKREQAMLACLQKYYAAAETLKDA-VKQSGDI 1318
            ...:    ::||..||.||:..|.|:|..|.|::::.:.....:.|:       |:| :..|||:
 Frog  1173 TNGE----NEKEVAVLEDLITNYVNIFNVSEDQVQQMETENRFITKW-------KEAQICHSGDL 1226

  Fly  1319 KIWISLNPNPENKTEEKTQVNATISPTKTAYELCREYSAKMQLPTHQLT------LYEVILNDSL 1377
            .|.:.:     .:.|....|...:.||....||.   :..|.:....||      .:|||.|..|
 Frog  1227 LIEVYV-----ERKEPDMCVIIRVPPTMETAELT---NCAMGIKNITLTKEMPWATFEVIENGEL 1283

  Fly  1378 ERPLHHDTKVFDVILNWSYWPEEDRKHNYLVVRPVEMLREIQRAVKNLATVTPGKE--------- 1433
            ||.:|:..||.:.:|.||  ...|....||:|:| ...|::         .|||.:
 Frog  1284 ERLMHYKEKVLETVLQWS--SLSDPGAAYLLVKP-HNTRDM---------TTPGLKSSHHMQSGH 1336

  Fly  1434 LRFADSRTK-----TFKTLQCELRDGKIVVSKKDKNDKTTIVREIFLQSSTAYLGCERKRDFPWS 1493
            ::|.:..:|     .|:.....||:.|:::.|..|:.|..  :|:.:.|...|.|.::|...|.|
 Frog  1337 MKFKEDPSKLLSGNKFQERYFVLRERKLLLYKDIKSIKPE--KELLVTSCKVYAGVKKKMKPPTS 1399

  Fly  1494 WAIT-FVERTQ 1503
            |.|| :.|:.|
 Frog  1400 WGITIYSEKHQ 1410

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP15B	NP_573183.2	RhoGAP_ARAP	1095..1277	CDD:239850	50/182 (27%)
arap2	XP_031751219.1	SAM_superfamily	10..71	CDD:417767	7/29 (24%)
		PH-like	394..481	CDD:418428	17/107 (16%)
		PH-like	495..579	CDD:418428	10/83 (12%)
		ArfGap_ARAP2	584..704	CDD:350081	25/134 (19%)
		PH-like	789..900	CDD:418428	15/111 (14%)
		PH-like	913..1008	CDD:418428	24/105 (23%)
		RhoGAP_ARAP	1012..1191	CDD:239850	50/182 (27%)
		Ubiquitin_like_fold	1223..1320	CDD:421700	31/107 (29%)
		PH-like	1333..1439	CDD:418428	21/80 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	101	1.000	Domainoid score	I6827
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001278
OrthoInspector	1	1.000	-	-		otm49356
Panther	1	1.100	-	-	O	PTHR45899
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1129
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.010