DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP15B and asap2

DIOPT Version :9

Sequence 1:	NP_573183.2	Gene:	RhoGAP15B / 32686	FlyBaseID:	FBgn0030808	Length:	1552	Species:	Drosophila melanogaster
Sequence 2:	XP_002935078.3	Gene:	asap2 / 100494274	XenbaseID:	XB-GENE-1002636	Length:	1025	Species:	Xenopus tropicalis

Alignment Length:	686	Identity:	128/686 - (18%)
Similarity:	221/686 - (32%)	Gaps:	210/686 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   126 LRILRAAPQIPPKPLNILLDQRSSICSEVSTTSVQTPGKADEDREGSRYASNASLDCSESSHSGK 190
            |.|......|||..||:|            |..|:|   ..|:::        |.|......:..
Frog   335 LTISHGTANIPPAKLNLL------------TCQVKT---NPEEKK--------SFDLISHDRTYH 376

  Fly   191 FKSQSPGYVDAVDSSIPQSDHPDPNGHHPQAESSSAEQSSGSQDGD---DDNNLLRSLGTTSKLL 252
            |:::     |..:..|..|          ..::|..|..:.:..||   .:||:::.|  |.:::
Frog   377 FQAE-----DETECQIWMS----------VLQNSKEEALNNAFKGDHSAGENNIVQEL--TKEII 424

  Fly   253 GEAIGERITFKAKGAKKRLDRNFKSSTEAISNIGADAGRSLKHASKRFGSNFSLGRNKDKADIGI 317
            .:.  :|:    .|.....|......|...:|:|...........:..|.::|
Frog   425 SDI--QRM----PGNDVCCDCGASDPTWLSTNLGILTCIECSGIHRELGVHYS------------ 471

  Fly   318 GGRPGGSGEMDLDRRQTMPSTEVFNTIQFSSPLN-RNGGLPDLRENDAKLQKEDYLRPDPDQEDD 381
                         |.|:: :.:|..|.:.....| .|.|..:|.|  |.|..:|.::|.|..:.:
Frog   472 -------------RIQSL-TLDVLGTSELLLAKNIGNSGFNELME--ACLPADDSVKPSPCSDMN 520

  Fly   382 GCYE------VPKTQGKPPSYDEALRSRPSPSDSPMSRN---LAQEAAQLVQLRNQRQLSSSSSN 437
            ...:      :.:...:...:|.|.:.. ...|:..||:   |.|..|:.|.|.....|::....
Frog   521 ARKDYITTKYIERKYARRKYHDNASKLH-GLCDAVKSRDIFTLVQLHAEGVDLTEGIPLANGHEQ 584

  Fly   438 GDESPRLPMPAFP-------------PPRLSQQPEQ-----------FRMDALQPPVRQKRRKNY 478
            |:.:..|.:.:..             ...|.:|..:           ...:.|:..:|.|...:.
Frog   585 GETALHLAVRSVDRNSLHIVDFLVQNSGNLDKQTAKGSTALHYCCLTDNAECLKLLLRGKASTDI 649

  Fly   479 EHIELRRPPVDSAQLEELNRAAAAAEREESLLISAKNAEAETKTPKPERSDSWEFYGEDENE-EE 542
            .: :....|:|.|  :.|..|..     |.|||.|.|.......   .....|..:..|.:| ::
Frog   650 AN-DAGETPLDIA--KRLKHAQC-----EDLLIQAMNGRFNAHV---HVEYEWRLHHMDLDESDD 703

  Fly   543 DRDEEQEGSSSPEPLYANQEATYGKLFEMATAGSSRSNVLTPNQVAEQQQLACITEDSELDACEG 607
            |.||:.:   .|.|:  .:|......|.:             ||  .|..:||:..::
Frog   704 DMDEKIQ---QPSPI--RREERPVSFFGI-------------NQ--GQPSVACLAREA------- 741

  Fly   608 AVGGVPLPQAVIEEFDPLSSKCSTLARSNKSNELLLLEHLLEEDTYGTVKAEQDDVSMCTSEEEP 672
                                     |...|......|.::::.:|||.|....:.....|.   |
Frog   742 -------------------------ASIAKDKPRTFLPNIIQNETYGAVIGNSNSPGNATG---P 778

  Fly   673 TTSAATSPKPQQPQIVHQNARLLSDSMENMLDSDQERAKPYLSRMPESANKASGPVDLASASRNR 737
            :|:.|....|:....||  :.:...|:.           |..|..|  |.|||. |...|.||.|
Frog   779 STTNAPPLPPRNTIKVH--STIFGSSIH-----------PTPSNTP--AWKASS-VTPESGSRQR 827

  Fly   738 TNWFVPDKASCSDVTPNTSKTTPPIE-----GDSPP 768
                     |.|| .|:.....||:.     .:|||
Frog   828 ---------SSSD-PPSIQPPVPPVRVTSTATNSPP 853

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP15B	NP_573183.2	RhoGAP_ARAP	1095..1277	CDD:239850
asap2	XP_002935078.3	BAR_ASAP2	34..248	CDD:153326
		PH_ASAP	297..403	CDD:270071	20/105 (19%)
		ArfGap_ASAP2	419..541	CDD:350074	24/157 (15%)
		ANKYR	498..676	CDD:223738	34/188 (18%)
		ANK repeat	550..582	CDD:293786	9/31 (29%)
		ANK repeat	585..618	CDD:293786	3/32 (9%)
		ANK repeat	620..651	CDD:293786	3/30 (10%)
		PHA02682	<902..>980	CDD:177464
		SH3_ASAP2	967..1022	CDD:212899
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910