DRSC/TRiP Functional Genomics Resources

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Protein Alignment RhoGAP15B and arap3

DIOPT Version :9

Sequence 1:NP_573183.2 Gene:RhoGAP15B / 32686 FlyBaseID:FBgn0030808 Length:1552 Species:Drosophila melanogaster
Sequence 2:XP_002933683.3 Gene:arap3 / 100492779 XenbaseID:XB-GENE-983598 Length:1805 Species:Xenopus tropicalis


Alignment Length:1675 Identity:365/1675 - (21%)
Similarity:605/1675 - (36%) Gaps:472/1675 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 RPVPAPRRLYPELRPANYENIEIRRPN-------SPSNNINHNNIKKLNINAENLHGNCAEKKLP 62
            :|||.||.::.::..|      |.:|:       ||:.:..:..      |..|..||..:::..
 Frog   132 KPVPKPRTVFNKITTA------IHKPHLISPYTISPATSSTYLE------NHTNAAGNIFQQEAF 184

  Fly    63 SSGQNKLILQENNS-DSQQPIYGPDANENVQEPVYATPRPAPRQRLPPAGEPEDSYPDPDDEVPL 126
            ....:.|.|:|.|| ..|||       |.|...|       ..|:...||..:..:|.|  .:|:
 Frog   185 VFRGSSLDLEEYNSLTGQQP-------ERVDLEV-------GTQKYSSAGAGKPFHPFP--SLPV 233

  Fly   127 RILRAAPQIPPKPLNILLDQRSSICSEVSTTSVQT----PGKADEDREGSRYASNASLD------ 181
            |..:.| .:|..     ||.|..:..|..||....    |..|..:.|.:.: |.:.|.      
 Frog   234 RQNKRA-SLPGS-----LDHRIFVQMEADTTPCSALSALPSFAGNEEEVTSF-STSPLSPQETLT 291

  Fly   182 -CSESSHSG-KFKSQSPGYVDAVDSSIPQSD--HPDPNGHHPQAESSSAEQSSGSQDGDDDNNL- 241
             .|...:|| ..::.:..:...:|:|.....  .||...|    |::||.:.. |..|..:..| 
 Frog   292 MISNEIYSGFDRRAATVNWTPDIDTSRNNLSLKPPDIKKH----EATSAPERL-SCSGVSELELP 351

  Fly   242 ---LRSLGTTSKL--LGEAIGERITFKAKGAKKRLDRNFKSSTEAISNI--GADAGRSLKHASKR 299
               .|...|..::  ..||:..| ..:|:..|...:..|::.|..:...  |.:.|::       
 Frog   352 VVPERPSSTIEEINPYCEAVFNR-NPQAQDPKDGKNTKFRTCTATMPMFTPGEEKGQA------- 408

  Fly   300 FGSNFSLGRNKDKADIGIGGRPGGSGEMDLDRRQTMPSTEVFNTIQFSSPLNRNGGLPDLRENDA 364
                    ||...|.|...|. |..|:.....:......|.::|:. :.|.|....||      :
 Frog   409 --------RNSSDAVIDRKGE-GEEGKTHRINQIAQNDQEGYSTVD-APPANNRFSLP------S 457

  Fly   365 KLQKEDYLRPDPDQEDDGCYEVPKTQGKPPSYDE-ALRSRPSPSD-----SPMSRNLAQ------ 417
            .|.|::.|       ||      .|.....|:.. :.||||..|.     ||....:.|      
 Frog   458 DLYKDEIL-------DD------LTISPYASFTSLSERSRPVLSTWLDKLSPQGNYVFQRRYVKF 509

  Fly   418 EAAQLVQLRNQRQLSSSSSNGDESPRLPMPAFPPPRLSQQPEQFRMDALQPPVRQKRRKNYEHIE 482
            :...|:...|.::|            .|....|...:..             .|..:...:|.:.
 Frog   510 DGQNLMYFSNDKEL------------YPKGVIPLSSIEM-------------ARSTKENKFEVVT 549

  Fly   483 LRRPPVDSAQLEELNRAAAAAEREESLLISAKNAEAETKTPKP----------ERSDSWEFYG-- 535
            ..|..|..|:.|        .:|.| ...:.:|...|.:...|          :||...|..|  
 Frog   550 KHRTFVFRAENE--------VQRNE-WCATIQNRVKEHRMVFPRLRLGCSSSCQRSGYLELKGYK 605

  Fly   536 --------EDE-----NEEEDRDEEQEGSSSPEPLYANQEATYGKLFEMATA-------GSSRSN 580
                    .||     ||:                          ||:|...       |.:..:
 Frog   606 SKIFAVLTTDELWIHKNEQ--------------------------LFKMGIGMFVIGMHGCTIRD 644

  Fly   581 VLTPN-QVAEQQQLACITEDSELDACEGAVGGVPLPQAVIEEFDPLSSKCSTLAR--SNKSNELL 642
            |...| ::...|::...|.:||.:..|..       :|::|......|......:  |||||::.
 Frog   645 VRNKNFELVTMQKIFSFTAESEREKKEWM-------EALLECISESLSDYEVAEKIWSNKSNKIC 702

  Fly   643 LLEHLLEEDTYGTVKAEQDD---VSMCTSEEEPTTSAATSPKPQQPQIVHQNARLLSDSMEN--- 701
                       ...:|...|   :::|....:.......|......::  |:.:|.:....|   
 Frog   703 -----------ADCRASNPDWASINLCVVICKQCAGVHRSLGTNISKV--QSLKLDTSIWSNEIV 754

  Fly   702 ----MLDSDQERAKPYLSRMPESANKASGPVDLASASRNRTNW------------FVPD------ 744
                :|.:|:.........:|........||:      .|.|:            |.|.      
 Frog   755 QLFIILGNDKANRFWAAKLLPSEMLHTDDPVE------RRRNFITQKYREGKYRGFHPQLNTQEE 813

  Fly   745 --KASCSDVT-PNTSKTTPPIEGDSPPTYLEAIGGSKDAAGNQENRSTI---GSRFRQTINAISN 803
              |..|:.|. ||...:...:..|:     |.:.   ||.| |:|...:   ...:|.:.|:|:.
 Frog   814 ILKVLCAAVAGPNLLNSVMQLFSDA-----ECVA---DAVG-QDNAMLVVQSSDTWRASTNSINA 869

  Fly   804 VKLKMDAMKRKASFRGANQRQSDVRVALQMVPRPSLSPLLIRYEGPLVR-------FPSGVVEDI 861
            ..|..|.         |||    .||..::     |.|::  :.|.|.:       |.:...:| 
 Frog   870 DSLGFDE---------ANQ----ARVYDEI-----LQPVV--HSGYLNKTAALTKLFTARKSKD- 913

  Fly   862 LKEMQNRKAILRERQFQTFLDQEMKT-------PREMIPL-----DTITTLQCVSNSRVTDTATH 914
              |......:| ||.. ||.|.:..:       |.|::.:     |.:.:...|...|       
 Frog   914 --EFHKHWCVL-ERSL-TFYDSDKASEPLGKIDPSEVVCMGVTRQDVLCSPSPVERFR------- 967

  Fly   915 FYCFEITTSQPKNGNGAGDAMSSNPNLLMTSSSSGNVKQQRVSHLYGVGKESERGVWMQKILESL 979
             |.|||..:..|......||..:    |.|.:|:             :||      |...:    
 Frog   968 -YMFEIYLATEKVHQFGTDAAET----LQTWTSA-------------IGK------WFTPV---- 1004

  Fly   980 TNSLPVKYTCH------YYRAGWCYLKNSITSE-WSGTWLVLRKSQRRLIFV--SEANGNVEKMD 1035
                    :||      :.|.|....|..:..: |...:.:|:|..   :|:  .:.|...:.::
 Frog  1005 --------SCHCLVAHEFQRVGRMRYKAMLNPDHWMEGFFLLKKCH---LFICPGDQNAAEDSVN 1058

  Fly  1036 LRKARCIVLKESDESIDNLHVESGPMLMIDCPPYAVYMIMSSARETKIWRHIIREVAHNNGFSLG 1100
            ||:     |:|...|:.:.:.|...||::......:|:...:..:...|...|:..|.::|..|.
 Frog  1059 LRQ-----LQELTVSLGSENTEKKDMLILVEKGRTLYLQGVTKADFLAWSTDIQAAACSSGNVLR 1118

  Fly  1101 DQQLTRYDVPVIVDKCINFVYIHGSMSEGIYRKSGSENSMHKLMSAFRADAFNVEITRNEYNEHD 1165
            :|||:|.|:|:|||.||.|:..:|...||||||:|:::.:..||..||.||.||::..::....|
 Frog  1119 EQQLSRNDIPIIVDSCIAFLTQYGLRHEGIYRKNGAKSRIKLLMDEFRKDARNVKLRISDNFIED 1183

  Fly  1166 VANVLKRFMRDLPERLLGKLTDSFVFVTEL----------AVASEKIPIYRELLARLSAIERETL 1220
            |.:|||||.|:|         |..:|.|||          ...|:::..|.||:..|..:.|.||
 Frog  1184 VTDVLKRFFREL---------DDPIFTTELHPQWKEAADNPEKSKRLEKYMELINHLPRVNRATL 1239

  Fly  1221 RRIVGHLVFISSQQAKNKMSVQNLTMIWGPTLLAKKSDELIYSQKEADVLSDLVVLYKNLFPCSA 1285
            ..::|||..:......|:|..:||.:::.|:|......    .:.|..|:.|::..|.::|    
 Frog  1240 AALIGHLYRVQKCADLNQMCTKNLALLFAPSLFQTDGK----GEHEVKVMEDIIDNYASVF---- 1296

  Fly  1286 DEIKREQAMLACLQKYYAAAETLKDA-VKQSGDIKIWISLNPNPENKTEEKTQVNATISPTKTAY 1349
             ||..||.....|:.  :...|.||. :.|:||:.|.:.|    |.|..: ..|...:||..||.
 Frog  1297 -EIDEEQVTQMDLEN--SLITTWKDVQLSQAGDLIIEVYL----EKKLPD-CCVTLKVSPVMTAE 1353

  Fly  1350 EL------CREYSAKMQLPTHQLTLYEVILNDSLERPLHHDTKVFDVILNWSYWPEEDRKHNYLV 1408
            ||      .|..||.|.:   .|| :||..|..||||||...||.:..|.|....|....  :|:
 Frog  1354 ELTNQVLDMRNISASMDV---WLT-FEVFENGELERPLHPKEKVLEQALQWCKLAEPSSA--FLL 1412

  Fly  1409 VRPVEMLREIQRAVKNLATVTPGKELRFADSRTKTFK--TLQCE-----------------LRDG 1454
            |:.:              .:..|..| |..::.:|.|  .|:|.                 :||.
 Frog  1413 VKKI--------------PIGEGSCL-FTGTKRETPKCGLLKCREETPKLLGSKFQERYFVIRDR 1462

  Fly  1455 KIVVSKKDKNDKTTIVREIFLQSSTAYLGCERKRDFPWSWAIT-FVERTQ 1503
            |:::.|:.|:.|..  ||..|.::..|:|..:|...|..|..| ::::.|
 Frog  1463 KLLLLKEKKSAKPE--REWPLDTAKVYMGIRKKMKAPSQWGFTIYLDKQQ 1510

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RhoGAP15BNP_573183.2 RhoGAP_ARAP 1095..1277 CDD:239850 64/191 (34%)
arap3XP_002933683.3 SAM_superfamily 7..66 CDD:417767
PH1_ARAP 486..577 CDD:270073 18/124 (15%)
PH-like 593..676 CDD:418428 19/115 (17%)
ArfGap_ARAP 687..802 CDD:350066 19/133 (14%)
PH-like 889..1001 CDD:418428 29/149 (19%)
PH-like 1014..1109 CDD:418428 19/102 (19%)
RhoGAP_ARAP 1114..1292 CDD:239850 64/190 (34%)
RA_ARAP3 1324..1421 CDD:340748 35/121 (29%)
PH-like 1420..1539 CDD:418428 23/94 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 101 1.000 Domainoid score I6827
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0001278
OrthoInspector 1 1.000 - - otm49356
Panther 1 1.100 - - O PTHR45899
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X1129
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
55.100

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