DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGAP15B and agap1

DIOPT Version :9

Sequence 1:	NP_573183.2	Gene:	RhoGAP15B / 32686	FlyBaseID:	FBgn0030808	Length:	1552	Species:	Drosophila melanogaster
Sequence 2:	XP_009300560.1	Gene:	agap1 / 100148154	ZFINID:	ZDB-GENE-130405-1	Length:	1255	Species:	Danio rerio

Alignment Length:	1305	Identity:	222/1305 - (17%)
Similarity:	391/1305 - (29%)	Gaps:	500/1305 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 KLNINAENLHGNCAEKK------LPSSGQNKLILQENNSDSQQPIYGPDANE------------- 89
            ||...|::.|   .|::      ||.:||||.|  ||.:..::.....|.::
Zfish   104 KLLKRAQHAH---KERELNQTCILPENGQNKAI--ENGAPGEKRAEDVDESDRLKRDAEHGKVCS 163

  Fly    90 ---------NVQEPVYATPRPAPRQRLPPAGEPEDSYPDPDDEVPLRILRA-------------- 131
                     .:::.:..|.|...        ||..::||...|.|..:..|
Zfish   164 TAAANGEKTGIRKKILKTSRSTE--------EPVSTWPDEPCEEPKSVKTAKESCISSLLAKGNG 220

  Fly   132 -----APQIPPKPLNILLDQRSSICSEVSTTSVQTPGKADEDREGSRYASNASLDCSESSHSGKF 191
                 |||.||...:..|.:||      .:....|.|:....|..|:...::|..|  ....|:.
Zfish   221 KSPKPAPQTPPTKRHPSLLRRS------FSFRHWTGGELIRIRALSKEKHHSSSGC--IGRDGEG 277

  Fly   192 KSQSPGYVDAVDSSIPQSDHPDP----------NGHHPQAESSSAEQSSGSQDGDDDNNLL---- 242
            ....||.| ..:.:..::|..:.          |......|....|:..|.....|:::||
Zfish   278 NQTQPGVV-LQNMAFAETDSTEKRNTLDVGEVLNKTDSVTELGRRERMKGKNRTLDNSDLLRLSD 341

  Fly   243 ---------------RSLGTTSKLLGEAIGERITFKAK---------------------GAKKRL 271
                           ||.|...||:....|   .|..|                     ||::|.
Zfish   342 KSLVDKEGFIRGMGSRSSGQERKLIRFFSG---IFSKKDGTSTPLSSPSNRALRKNGLLGAQQRA 403

  Fly   272 DRNF-KSSTEAISNIGAD----------AGRSLKHASKRFGSNFSLGRN---------------K 310
            :..: :||:|:::....|          ..||:.........|.:.|::               .
Zfish   404 EMGYSQSSSESVNGCPLDDAFVNSQEWTLSRSVPELKVGIVGNLASGKSALVHRYLTGTYVQEES 468

  Fly   311 DKADIGIGGR------PGGSGEMDLDRRQTMPSTEVF--------------NTIQFSSPLNRNGG 355
            .:||:..|||      ..|...:.|.|.:..|....|              :.|.|.:..:....
Zfish   469 PEADVDAGGRFKKEIVVDGQSYLLLIRDEGGPPEAQFALWVDAVIFVFSLEDEISFQTVYHYYSR 533

  Fly   356 LPDLRENDAKLQKEDYLRPDPDQEDDGCYEVP----KTQGKPPSYDEALRSRPSPSDSPMSRNLA 416
            :.:.| |.|                    |||    .||      |....:.|...|...:|.|:
Zfish   534 MANYR-NTA--------------------EVPLVLVGTQ------DAISAANPRVIDDTRARKLS 571

  Fly   417 -----------------------QEAAQ-LVQLRNQRQLSSSSSNGDESPRLPMPAFPPPRLSQQ 457
                                   |:.|| :|.:|.::|||.       .|...:|..|
Zfish   572 NDLKRCTYYETCATYGLNVERVFQDVAQKVVAIRKKQQLSI-------GPCKSLPNSP------- 622

  Fly   458 PEQFRMDALQPPVRQKRRKNYEHIELRRPPVDSAQLEELNRAAAAAEREESLLISAKNAEAETKT 522
                                 .|..:...||.:..:.:.:....:.....|.:.|         |
Zfish   623 ---------------------SHSSVCAAPVSAVHISQNSNGGGSLSDYSSSVPS---------T 657

  Fly   523 PKPERSDSWEFYGEDENEEEDRDEEQEGSSSPEPLYANQEATYGKLFEMATAGSSRSNVLTPNQV 587
            |             ..:::|.|.:..:.:::|.|:....:              .|||:.|..:.
Zfish   658 P-------------STSQKELRIDVPQTANTPTPVRKQSK--------------RRSNLFTSRKG 695

  Fly   588 AEQQQLACITEDSELDACEGAVG---GVPLPQAVIEEFDPLSSKCSTLARSNKS----------- 638
            :|..:     |...:|....::|   .:|:.|.::            |.||.||
Zfish   696 SEPDR-----EKKGMDGRADSIGSGRAIPIKQGML------------LKRSGKSLNKEWKKKYVT 743

  Fly   639 --NELLLLEHLLEEDTYGTVKAEQDDVSMCT----SEEEP---TTSAATSPKPQQPQIVHQNARL 694
              :..:|..|....|....|..::.|:...|    .:..|   :|.||.|||...
Zfish   744 LCDNGVLTYHPSLHDYMQNVHGKEIDLLRTTVKVPGKRPPRAISTCAAPSPKTNG---------- 798

  Fly   695 LSDSMENMLDSDQERAKPYLSRMPESANKASGPVDLASA-------SR----NRTNWFVPDKASC 748
            |:..|.||          .|.:.|.|...:|....:||.       ||    ::.::.|......
Zfish   799 LTKDMSNM----------QLGQAPGSVTSSSSASQMASGISLVSFNSRPDGMHQRSYSVSSADQW 853

  Fly   749 SDVT--------------------PNTSKTTPPIEGDSPPT-----------------YLEAIGG 776
            |:.|                    |:.|.||.| :.|.||:                 .::...|
Zfish   854 SEATVIANSGISTDTGLGDSVCSSPSISSTTSP-KMDPPPSPHANRKKHRRKKSTSNFKVDGFSG 917

  Fly   777 SKDAAGNQENRSTIGSRFRQTINAISNVKLKMDAMK--------RKASFRGANQRQSDVRVALQM 833
            :.:|.......:.:|| .|...|..||.:.:.|..:        :..:|...:..:.|..|
Zfish   918 TAEAKHRAWKLNRVGS-LRNIYNNSSNAEEQEDNFEFVIVSLTGQTWNFEATSYEERDAWV---- 977

  Fly   834 VPRPSLSPLLIRYEGPLVRFPSGVVEDILKEMQNRKAILRERQFQTFLDQEMKTPREMIPLDTIT 898
                                 ..:...||..:|:.::..::        ..:.:..|.|.|.::.
Zfish   978 ---------------------QAIESQILASLQSCESSKQK--------SRLSSQSEAIALQSVR 1013

  Fly   899 TLQCVSNSRVTDTATHFYCFEITTSQPKNGNGAGDAMSSNPNLLMTSSSSGNVKQQRVSHLYGVG 963
            .::  .|:|         |.:.....|       |..|.|...|:....|| :.:...:||..|
Zfish  1014 NMR--GNTR---------CVDCEAQNP-------DWASLNLGALICIECSG-IHRNLGTHLSRV- 1058

  Fly   964 KESERGVW---MQKILESLTNSL--------------PVKYTCHYYRAGW--------CYLKNSI 1003
            :..:...|   :.|::.::.|.|              |........|..|        .:|.:..
Zfish  1059 RSLDLDEWPLELIKVMSAIGNELANSVWEANAQGRLKPAPDASREERERWIRAKYEQKLFLASLT 1123

  Fly  1004 TSEWSGTWLVLR---KSQRRLIFVSEANGNVEKM-------DLRKARCIVLKESDESIDNLHVES 1058
            .:|.|....:||   :...||:.:..|:|:.:::       |.|.|..:..::.:..|..|.|..
Zfish  1124 CTELSLGQQLLRATAEEDLRLVVILLAHGSRDEVNETCGEGDGRTALHLACRKGNVVITQLLVWY 1188

  Fly  1059 GPMLM 1063
            |..:|
Zfish  1189 GVDIM 1193

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP15B	NP_573183.2	RhoGAP_ARAP	1095..1277	CDD:239850
agap1	XP_009300560.1	Centaurin_gamma	439..601	CDD:133303	30/188 (16%)
		RAS	440..607	CDD:214541	32/193 (17%)
		PH_AGAP	716..989	CDD:241281	57/331 (17%)
		PH	719..>783	CDD:278594	13/75 (17%)
		PH	<933..984	CDD:278594	9/76 (12%)
		ArfGap	1008..1118	CDD:279720	21/129 (16%)
		Ank_2	1133..1223	CDD:289560	14/61 (23%)
		ANK	1133..>1222	CDD:238125	14/61 (23%)
		ANK repeat	1165..1196	CDD:293786	8/29 (28%)
		ANK repeat	1198..1223	CDD:293786
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900