DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP15B and appl2

DIOPT Version :9

Sequence 1:	NP_573183.2	Gene:	RhoGAP15B / 32686	FlyBaseID:	FBgn0030808	Length:	1552	Species:	Drosophila melanogaster
Sequence 2:	NP_001121547.1	Gene:	appl2 / 100000135	ZFINID:	ZDB-GENE-081016-2	Length:	662	Species:	Danio rerio

Alignment Length:	428	Identity:	84/428 - (19%)
Similarity:	141/428 - (32%)	Gaps:	155/428 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly  1143 LMSAFRADAFNVEITRNEYNEHDVANVLKRFMRDLPERLLGKLTDSFVFVTELAVASEKIPIYRE 1207
            |:|.|..||..:....|:                    ||..:...|....|:|:|:|      :
Zfish    23 LLSVFEEDAGTLTNYTNQ--------------------LLQSMQRVFGAQNEMALATE------Q 61

  Fly  1208 LLARLSAIERETLRRIVGHLVFISSQQAKNKMSVQNLTMIWGPTLLAKKSDELIYSQ---KEADV 1269
            |..:|...|::......|....|::.|...| ||:.|..:.. .|..:.:|::::..   :|.|
Zfish    62 LSKQLLEYEKQNFALAKGDEEVINTLQQFAK-SVEELNALHS-ELSTQIADKMVFPMVQFREKD- 123

  Fly  1270 LSDLVVLYKNLFPCSADEIKREQAMLACLQKYYAAAETLKDAVKQSGDIKIWISLNPNPENKTEE 1334
            |:::..| |.:|..:.||  .|.||:    ||                       :..|:.:..|
Zfish   124 LTEISTL-KEIFSIATDE--HEAAMV----KY-----------------------SRLPKKRENE 158

  Fly  1335 KTQVNATISPTKTAYELCREYSAKMQL-----------------P----TH-QLTLY----EVI- 1372
            |.:....   .:.||...:::.|.||.                 |    || |:..:    |::
Zfish   159 KVKAEVV---REVAYSRRKQHQAAMQYYCALNALQYRKRVAMLEPMLGYTHAQINFFKKGMELVS 220

  Fly  1373 ------------LNDSLERPLHHDTKVF-----------DVILNWSYWPEED---------RKHN 1405
                        :|:|:|..|..|.:|.           |.:    |.|:.|         :|..
Zfish   221 KKLDSFLNSVSNMNESIESQLEIDAEVMRSSQRELLSVDDSV----YMPDHDQAAVSRALIQKAG 281

  Fly  1406 YLVVRPVEMLREIQRAVKNLATVTPGKEL-----------RFADSRTKTFKTLQCELRDGKIVVS 1459
            ||.:|....|  :..|...|...|.|..|           ...|....:...:.||  |.:....
Zfish   282 YLNIRNKTGL--VTTAWDRLFFFTQGGNLMCQPRGAVAGGMVLDLDNSSVMAVDCE--DRRYCFQ 342

  Fly  1460 KKDKNDKTTIVREIFLQSSTAYLGCERKRDFPWSWAIT 1497
            ....|.||:::           |..|.||::. .|..|
Zfish   343 ITSPNGKTSLI-----------LQAESKREYE-EWICT 368

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP15B	NP_573183.2	RhoGAP_ARAP	1095..1277	CDD:239850	28/136 (21%)
appl2	NP_001121547.1	BAR	21..235	CDD:299863	51/273 (19%)
		BAR-PH_APPL	253..375	CDD:270067	27/136 (20%)
		PH	277..377	CDD:278594	23/108 (21%)
		PTB_APPL	488..614	CDD:269980
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900