DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4928 and UNC93A

DIOPT Version :9

Sequence 1:	NP_573179.1	Gene:	CG4928 / 32682	FlyBaseID:	FBgn0027556	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_061847.2	Gene:	UNC93A / 54346	HGNCID:	12570	Length:	457	Species:	Homo sapiens

Alignment Length:	458	Identity:	187/458 - (40%)
Similarity:	287/458 - (62%)	Gaps:	8/458 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 RILKNISIISIAFMVQFTAFQGTANLQSSINAKDGLGTVSLSAIYAALVVSCIFLPTLIIRKLTV 105
            |.|:|:.::|..|::.|||:.|..:||||:.:::|||..:||.:|..:::|.:|||.|:|.:|..
Human     3 RSLRNVLVVSFGFLLLFTAYGGLQSLQSSLYSEEGLGVTALSTLYGGMLLSSMFLPPLLIERLGC 67

  Fly   106 KWTLVCSMLCYAPYIAFQLFPRFYTLVPAGILVGMGAAPMWASKATYLTQVGQVYAKITEQAVDA 170
            |.|::.||..|..:.....|..:|||:|..||:|:||||:|:::.||||..|..:|:...:....
Human    68 KGTIILSMCGYVAFSVGNFFASWYTLIPTSILLGLGAAPLWSAQCTYLTITGNTHAEKAGKRGKD 132

  Fly   171 IIVRFFGFFFLAWQSAELWGNLISSLVLSSGAHGGGSSSNTTVSEEDLQFCGANFCTTGSGGHGN 235
            ::.::||.|||.:||:.:|||||||||.      |.:.|..|:.||.|..|||:.|...:....:
Human   133 MVNQYFGIFFLIFQSSGVWGNLISSLVF------GQTPSQETLPEEQLTSCGASDCLMATTTTNS 191

  Fly   236 LERPPEDEIFEISMIYLSCIVAAVCIIAFFLDPLKRYGEKRKGSNSAAELSGLQLLSATFRQMKK 300
            .:||.:..::.:..||....|.||.:||.||.|::....:.:|...:...  ...|.:||:..:.
Human   192 TQRPSQQLVYTLLGIYTGSGVLAVLMIAAFLQPIRDVQRESEGEKKSVPF--WSTLLSTFKLYRD 254

  Fly   301 PNLQLLIPITVFIGMEQAFIGADFTQAYVACALGVNKIGFVMICFGVVNALCSILFGSVMKYIGR 365
            ..|.|||.:.::.|::|.|:.:::|::||.|.||:..:|:|||||...:||||:|:|.|.:|.||
Human   255 KRLCLLILLPLYSGLQQGFLSSEYTRSYVTCTLGIQFVGYVMICFSATDALCSVLYGKVSQYTGR 319

  Fly   366 TPIIVLGAVVHFTLITVELFWRPNPDNPIIFYAMSGLWGVGDAVWQTQINGLYGLLFRRNKEAAF 430
            ..:.|||||.|.:.:...|.|||..|:..:|:..||||||.|||||||.|.|||:||.::|||||
Human   320 AVLYVLGAVTHVSCMIALLLWRPRADHLAVFFVFSGLWGVADAVWQTQNNALYGVLFEKSKEAAF 384

  Fly   431 SNYRLWESAGFVIAYAYATTLCTQMKLYILLAVLTLGCIGYVIVEILYRKKQRKLKKQEKLEAAE 495
            :||||||:.|||||:.|:..||..:||||||.||:|..:.|.:||.:..|...:.....::..||
Human   385 ANYRLWEALGFVIAFGYSMFLCVHVKLYILLGVLSLTMVAYGLVECVESKNPIRPHAPGQVNQAE 449

  Fly   496 KEK 498
            .|:
Human   450 DEE 452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4928	NP_573179.1	MFS	49..>155	CDD:328737	44/105 (42%)
CG4928	NP_573179.1	MFS_1	<255..426	CDD:331686	72/170 (42%)
UNC93A	NP_061847.2	MFS	8..428	CDD:119392	178/427 (42%)
UNC93A	NP_061847.2	MFS_1	11..398	CDD:284993	163/394 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144964
Domainoid	1	1.000	242	1.000	Domainoid score	I2237
eggNOG	1	0.900	-	-		E1_KOG3097
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10356
Inparanoid	1	1.050	376	1.000	Inparanoid score	I2093
Isobase	1	0.950	-	0	Normalized mean entropy	S4703
OMA	1	1.010	-	-		QHG54908
OrthoDB	1	1.010	-	-		D1145833at2759
OrthoFinder	1	1.000	-	-		FOG0003220
OrthoInspector	1	1.000	-	-		otm41213
orthoMCL	1	0.900	-	-		OOG6_103480
Panther	1	1.100	-	-	LDO	PTHR19444
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2890
SonicParanoid	1	1.000	-	-		X2635
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750