DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4928 and unc-93

DIOPT Version :9

Sequence 1:	NP_573179.1	Gene:	CG4928 / 32682	FlyBaseID:	FBgn0027556	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_001021218.1	Gene:	unc-93 / 175466	WormBaseID:	WBGene00006822	Length:	705	Species:	Caenorhabditis elegans

Alignment Length:	444	Identity:	156/444 - (35%)
Similarity:	256/444 - (57%)	Gaps:	19/444 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 KWRILKNISIISIAFMVQFTAFQGTANLQSSINAKDGLGTVSLSAIYAALVVSCIFLPTLIIRKL 103
            |.:|:.|:.|:|:||:..||||.|..|||:|:|.  .||:.||.|:|.:|.:|.:|:|:.:|.:|
Worm   243 KRKIMSNLWILSVAFLFLFTAFNGLQNLQTSVNG--DLGSDSLVALYLSLAISSLFVPSFMINRL 305

  Fly   104 TVKWTLVCSMLCYAPYIAFQLFPRFYTLVPAGILVGMGAAPMWASKATYLTQVGQVYAKITEQAV 168
            ..|.|.:.::..|..||...|.|.:.:::||.|..|:.|:.:|.:|..|:|::|..||.:..::.
Worm   306 GCKLTFLIAIFVYFLYIVINLRPTYSSMIPASIFCGIAASCIWGAKCAYITEMGIRYASLNFESQ 370

  Fly   169 DAIIVRFFGFFFLAWQSAELWGNLISSLVLSSGAHGGGSSSNTTVSEEDLQF--CGANFCTTGSG 231
            ..:||||||:||:.....::.||::||.:.:.      |.|......||..:  ||..|....|.
Worm   371 TTVIVRFFGYFFMIVHCGQVVGNMVSSYIFTL------SYSQALRGPEDSIYDSCGYQFPKNLSD 429

  Fly   232 ----GHGNLERPPEDEIFEISMIYLSCIVAAVCIIAFFLDPLKRYGEKRKGSNSAAELSGLQLLS 292
                ...||.|||:.....:.:.||:|::.:..|::.||:.|.:....||    .|:....::..
Worm   430 LTELAESNLARPPQKVYVAVCLAYLACVIISGMIMSMFLNALAKDARNRK----MAQKFNSEIFY 490

  Fly   293 ATFRQMKKPNLQLLIPITVFIGMEQAFIGADFTQAYVACALGVNKIGFVMICFGVVNALCSILFG 357
            ...:.:......||:|:|:|.|:||||:...:|:|:|.|.||:.:|||||.|||:.:|:||::||
Worm   491 LMLKHLINIKFMLLVPLTIFNGLEQAFLVGVYTKAFVGCGLGIWQIGFVMACFGISDAVCSLVFG 555

  Fly   358 SVMKYIGRTPIIVLGAVVHFTLITVELFWRPNPDNPIIFYAMSGLWGVGDAVWQTQINGLY-GLL 421
            .::|..||.|:.|.||||:..:|...:.|..|..:..|||.::.:||:.|.||.|||||.: .|:
Worm   556 PLIKLFGRMPLFVFGAVVNLLMIVTLMVWPLNAADTQIFYVVAAMWGMADGVWNTQINGFWVALV 620

  Fly   422 FRRNKEAAFSNYRLWESAGFVIAYAYATTLCTQMKLYILLAVLTLGCIGYVIVE 475
            .|::.:.||:.||.|||.|..|.:|....:..::.|.|...:|.||..|::.:|
Worm   621 GRQSLQFAFTKYRFWESLGIAIGFALIRHVTVEIYLLITFFMLLLGMCGFLAIE 674

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4928	NP_573179.1	MFS	49..>155	CDD:328737	40/105 (38%)
CG4928	NP_573179.1	MFS_1	<255..426	CDD:331686	63/171 (37%)
unc-93	NP_001021218.1	MFS	250..673	CDD:119392	152/434 (35%)
unc-93	NP_001021218.1	MFS_1	250..643	CDD:284993	144/404 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160158444
Domainoid	1	1.000	206	1.000	Domainoid score	I1700
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10356
Inparanoid	1	1.050	295	1.000	Inparanoid score	I1666
Isobase	1	0.950	-	0	Normalized mean entropy	S4703
OMA	1	1.010	-	-		QHG54908
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003220
OrthoInspector	1	1.000	-	-		otm14398
orthoMCL	1	0.900	-	-		OOG6_103480
Panther	1	1.100	-	-	LDO	PTHR19444
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2890
SonicParanoid	1	1.000	-	-		X2635
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	13.880