DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4928 and unc93b1

DIOPT Version :9

Sequence 1:	NP_573179.1	Gene:	CG4928 / 32682	FlyBaseID:	FBgn0027556	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	XP_012815862.1	Gene:	unc93b1 / 100101743	XenbaseID:	XB-GENE-492943	Length:	604	Species:	Xenopus tropicalis

Alignment Length:	601	Identity:	127/601 - (21%)
Similarity:	243/601 - (40%)	Gaps:	116/601 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 NAGFENDEPVKPKA--------GFEPDTASLREKVVLNPGEKWRILKNISIISIAFMVQFTAFQG 62
            |...::|.||...|        |.:||.....|:......::...:|::...|:...:.:..:.|
Frog    29 NYAVQDDTPVLDGANAQVEDFLGEKPDYDEEAEEKRYYRRKRLLTVKSVVFASLGAALTYGVYLG 93

  Fly    63 TANLQ--------------SSINAKDGLGTVSLSAIYAALVVSCIFLPTLIIRKLTVKWTLVCSM 113
            ...:|              |:|..:| :.:..|..|....:|:.::.|.| ||....||.:..|.
Frog    94 LLQMQLILHYDETYRDVKYSNIGLQD-IDSKMLMGINVTPIVALLYTPVL-IRFFGTKWMMFLSS 156

  Fly   114 LCYAPYIAFQLFPRFYTLVPAGILVGMGAAPMWASKATYLTQVGQVY--------AKITEQ---- 166
            ..||.:::...:.|:|||||:..::|:...|.|||...|:|::.|.|        ..:.||
Frog   157 GIYALFVSTNYWERYYTLVPSATVIGVMIVPFWASLGNYITRMAQKYYEFVNYKEENVREQRRVP 221

  Fly   167 --AVDAIIVRFFGFFFLAWQSAELWGNLISSLVLSSGAHGGGSSSNTTVSEEDLQFCGANFCTTG 229
              |....|:.|...|:..:..:.:...|.....||...:   |.::|..:..|   |||..
Frog   222 RGASHRYIIIFQSIFYSLFHISFVLAQLPVHFFLSKFFY---SYNHTLFNVRD---CGAAI---- 276

  Fly   230 SGGHGNLER---------PPEDEIFEISMIYLSCIVAAVCIIAFFL---------DPLKRYGEKR 276
              .||.|..         ||     .:::||:...:....:::..|         .|.:....:.
Frog   277 --QHGILPNFNLTVLHTLPP-----SLNLIYVESALMGAALVSMLLILLLCGSAYRPTEEIDLRS 334

  Fly   277 KGSNSAAELSGLQLLSATFRQMKKPNLQLLIPITVFIGMEQAFIGADFTQAYVACALGVNKIGFV 341
            .|..:..:|        .|:..:...|:.|.|..::.|.|..|....|...|..|:||:..:.|:
Frog   335 IGWGNIFQL--------PFKHARDYRLRCLAPYFLYSGFEVLFACTCFALCYGVCSLGLESLPFL 391

  Fly   342 MICFGVVNALCSILFGSVMKYIGRTPIIVLGAVVHFTLITVELFWRPNP----DNPIIFYAMSGL 402
            :..:|:..:..|.|...::::..:.| :|.|.::|..::....||.|.|    ..|:: |.::.|
Frog   392 LTAYGISASFSSSLALCMLRFPRQIP-LVGGTLLHCCILIGLFFWSPTPKLQSQKPLL-YLVAIL 454

  Fly   403 WGVGDAVWQTQINGLYGLLF--RRNKEAAFSNYRLWESAGFVIAYAYATTLCTQMKLYILLAVLT 465
            ||||.|:.::.::.:.|:.:  :..::..|:.|...::....|.|.::....| .||.|:||...
Frog   455 WGVGSALNKSGLSIIIGVFYEDKERQDFVFTIYHWLQALAIFIVYLWSGIPVT-AKLGIMLASAL 518

  Fly   466 LGCIGYVIVE------ILYR-----KKQRKLKKQEKLEAAEKEKEAAAAAAAAALAAAEAGADGV 519
            :..:.|:.:|      :.||     ..:.|:|....:|....:               |:|::|.
Frog   519 ISVLSYLWMEHKLSCKVPYRVPKIPAPRHKVKGYRYMEEENSD---------------ESGSEGE 568

  Fly   520 EETDDELDDLEEDIVV 535
            :|..:..:..|||..|
Frog   569 KEQSEGGESEEEDKTV 584

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4928	NP_573179.1	MFS	49..>155	CDD:328737	30/119 (25%)
CG4928	NP_573179.1	MFS_1	<255..426	CDD:331686	37/185 (20%)
unc93b1	XP_012815862.1	MFS_unc93B1	77..533	CDD:340966	104/485 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910