DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DENR and DENR

DIOPT Version :9

Sequence 1:	NP_001259630.1	Gene:	DENR / 32679	FlyBaseID:	FBgn0030802	Length:	189	Species:	Drosophila melanogaster
Sequence 2:	NP_003668.2	Gene:	DENR / 8562	HGNCID:	2769	Length:	198	Species:	Homo sapiens

Alignment Length:	197	Identity:	94/197 - (47%)
Similarity:	138/197 - (70%)	Gaps:	15/197 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 DVGTNSVADRLQLGPREG----VTYPIQMKYCGHCTMPIEYCEYYPEYEKCKEWLELHMPDDFER 65
            |:..:|.|| .:..||..    ..||:::.|||.|::|.|||||.|:..||::|||.:.|::|.:
Human     4 DISESSGAD-CKGDPRNSAKLDADYPLRVLYCGVCSLPTEYCEYMPDVAKCRQWLEKNFPNEFAK 67

  Fly    66 LKIE----EEAAAAD-----GTDDDKKRQKRGGKGLLRVKKKEDVPKRICVSRAARGKKKSVTVV 121
            |.:|    :||..::     |.:::||:|||||:|.::.||| .||:::.:::..|.|||.||.|
Human    68 LTVENSPKQEAGISEGQGTAGEEEEKKKQKRGGRGQIKQKKK-TVPQKVTIAKIPRAKKKYVTRV 131

  Fly   122 TGLSTFDIDLKVAAKFFGTKFACGSSVTGDDEIVIQGDVKDDLFDVIPEKWAEIDEDVIEDLGDQ 186
            .||:||:||||.|.:||..||:||:||||:|||:||||..||:.|||.|||.|:|:|.|||||:.
Human   132 CGLATFEIDLKEAQRFFAQKFSCGASVTGEDEIIIQGDFTDDIIDVIQEKWPEVDDDSIEDLGEV 196

  Fly   187 KR 188
            |:
Human   197 KK 198

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DENR	NP_001259630.1	eIF1_SUI1_like	26..183	CDD:294159	83/165 (50%)
DENR	NP_003668.2	DRP1	28..193	CDD:273472	86/169 (51%)
DENR	NP_003668.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	72..110		14/42 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147881
Domainoid	1	1.000	88	1.000	Domainoid score	I7973
eggNOG	1	0.900	-	-		E1_COG0023
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6275
Inparanoid	1	1.050	193	1.000	Inparanoid score	I3862
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55305
OrthoDB	1	1.010	-	-		D1490022at2759
OrthoFinder	1	1.000	-	-		FOG0004744
OrthoInspector	1	1.000	-	-		oto88772
orthoMCL	1	0.900	-	-		OOG6_102629
Panther	1	1.100	-	-	LDO	PTHR12789
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5714
SonicParanoid	1	1.000	-	-		X3339
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800