DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nprl2 and Nprl2

DIOPT Version :9

Sequence 1:	NP_573174.1	Gene:	Nprl2 / 32677	FlyBaseID:	FBgn0030800	Length:	412	Species:	Drosophila melanogaster
Sequence 2:	NP_061367.1	Gene:	Nprl2 / 56032	MGIID:	1914482	Length:	380	Species:	Mus musculus

Alignment Length:	380	Identity:	174/380 - (45%)
Similarity:	251/380 - (66%)	Gaps:	11/380 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 KIRCIFLSEFHATAGCKISCQVPDNYISKDVFDAINVYIIPKQHLQRCILTVNAMDVKIVGYPVG 103
            :|.|||.||||.|.|.||:.|||:::||:::||.:.||||.|..||..::||.||:.|::|.||.
Mouse     6 RIECIFFSEFHPTLGPKITYQVPEDFISRELFDTVQVYIITKPELQNKLITVTAMEKKLIGCPVC 70

  Fly   104 IQDQQKYARNAFLFNLCFVCDSRARSVQYEPVVKKLSEYLIMMEEESCFLSREDDKRRLQNIFET 168
            | :.:||:|||.||||.||||::|::...||:||||:.||..:|.||.|:|.|:.|::|..|...
Mouse    71 I-EHKKYSRNALLFNLGFVCDAQAKTCALEPIVKKLAGYLTTLELESSFVSNEESKQKLVPIMTI 134

  Fly   169 VLRDLNERKVATI-VEGDNTIYLKIVMHKPDPPPVKDHMVPLLLANLRDAPLDNWDLTTQQILPY 232
            :|.:||.....|: ::..|||:||::..:||||..:::.||:...:..|.....|||||||||||
Mouse   135 LLEELNASGRCTLPIDESNTIHLKVIEQRPDPPVAQEYDVPVFTKDKEDFFSSQWDLTTQQILPY 199

  Fly   233 INGINHVARIAAEADVETDLVKSCIQNLVYYGVVQLLPILKYSNVYM-TQNLKHLIQSASLSGAC 296
            |:|..||.:|:||||||.:||:..||||:|||||.|:.||:|||||. |..::.|:...||..||
Mouse   200 IDGFRHVQKISAEADVELNLVRIAIQNLLYYGVVTLVSILQYSNVYCPTPKVQDLVDDKSLQEAC 264

  Fly   297 RKYVALRPDKTLPSVQRIFQFYASMTHGVTLRAICQRLCPQHHNIDERRMVIFGLQHRFIRCIHK 361
            ..||..:..|. .|::.:||.|.|::.|.|:|.:..|...|..::|||:::.|||....||.:.|
Mouse   265 LSYVTKQGHKR-ASLRDVFQLYCSLSPGTTVRDLIGRHPQQLQHVDERKLIQFGLMKNLIRRLQK 328

  Fly   362 YPVFTG----SVPSGRQKMYTGLISFDEICCKTGLSPCTIERDIEKDTNVTVIWK 412
            |||...    |.|:   ::|||..|:||||||||:|...::..:|.|.|:.:.||
Mouse   329 YPVRVSREERSHPA---RLYTGCHSYDEICCKTGMSYHELDERLENDPNIIICWK 380

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nprl2	NP_573174.1	NPR3	40..403	CDD:305178	169/368 (46%)
Nprl2	NP_061367.1	Interaction with PDPK1. /evidence=ECO:0000250	1..133		65/126 (52%)
Nprl2	NP_061367.1	NPR3	7..370	CDD:390239	169/368 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849296
Domainoid	1	1.000	255	1.000	Domainoid score	I2036
eggNOG	1	0.900	-	-		E1_KOG3789
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4771
Inparanoid	1	1.050	331	1.000	Inparanoid score	I2423
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55115
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005663
OrthoInspector	1	1.000	-	-		oto92815
orthoMCL	1	0.900	-	-		OOG6_103955
Panther	1	1.100	-	-	LDO	PTHR12991
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R837
SonicParanoid	1	1.000	-	-		X4639
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790