DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nprl2 and nprl2

DIOPT Version :9

Sequence 1:	NP_573174.1	Gene:	Nprl2 / 32677	FlyBaseID:	FBgn0030800	Length:	412	Species:	Drosophila melanogaster
Sequence 2:	NP_001039312.1	Gene:	nprl2 / 559391	ZFINID:	ZDB-GENE-060825-93	Length:	379	Species:	Danio rerio

Alignment Length:	380	Identity:	168/380 - (44%)
Similarity:	241/380 - (63%)	Gaps:	6/380 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 TEGKIRCIFLSEFHATAGCKISCQVPDNYISKDVFDAINVYIIPKQHLQRCILTVNAMDVKIVGY 100
            |..:|.|||.||||.|.|.||:.|||:.|||:::||.:.||||.|..||..::||.||:.|::|.
Zfish     3 TYRRIDCIFFSEFHPTLGPKITYQVPEEYISRELFDTVQVYIITKPELQNKLITVTAMEKKLIGC 67

  Fly   101 PVGIQDQQKYARNAFLFNLCFVCDSRARSVQYEPVVKKLSEYLIMMEEESCFLSREDDKRRLQNI 165
            ||.| :.:||.|||.||||..|||:..::...||:||||:.||..:|.||.|:|.|:.|::|..|
Zfish    68 PVCI-EHKKYRRNALLFNLGLVCDASTKTSALEPIVKKLAGYLTTLELESGFISNEESKQKLLPI 131

  Fly   166 FETVLRDLNERKVATI-VEGDNTIYLKIVMHKPDPPPVKDHMVPLLLANLRDAPLDNWDLTTQQI 229
            ..|:|.|||.....|: ::..|||:||::..:.||..|:::.||:...|........||||||||
Zfish   132 MSTLLEDLNITGACTLPIDDSNTIHLKLIEQRKDPLVVQEYDVPVFTKNKDHFIKSQWDLTTQQI 196

  Fly   230 LPYINGINHVARIAAEADVETDLVKSCIQNLVYYGVVQLLPILKYSNVY-MTQNLKHLIQSASLS 293
            ||:::|..|:.:|:||||||.:||:..:|||:||.||.|:.|.:||||| .|..:::||....|.
Zfish   197 LPFVDGYRHIQKISAEADVELNLVRIAVQNLLYYDVVTLVSIFQYSNVYCTTPKVQNLIDKKCLQ 261

  Fly   294 GACRKYVALRPDKTLPSVQRIFQFYASMTHGVTLRAICQRLCPQHHNIDERRMVIFGLQHRFIRC 358
            ..|..||:....:|  |::.:||.|..:|.|.|:|.:|.|...|...:|:|:::.|||....||.
Zfish   262 EECLHYVSKPGQRT--SLRDVFQLYCGLTPGTTVRDLCSRYSHQLQKVDDRKLIQFGLMKGLIRR 324

  Fly   359 IHKYPV-FTGSVPSGRQKMYTGLISFDEICCKTGLSPCTIERDIEKDTNVTVIWK 412
            :.|||| ......|...::|||..|:||||||||:|...::..:|.|.|:.|.||
Zfish   325 LQKYPVKVVRDERSRPPRLYTGCHSYDEICCKTGMSYKELDERLENDPNIVVCWK 379

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nprl2	NP_573174.1	NPR3	40..403	CDD:305178	161/365 (44%)
nprl2	NP_001039312.1	NPR3	5..369	CDD:305178	161/366 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594884
Domainoid	1	1.000	237	1.000	Domainoid score	I2265
eggNOG	1	0.900	-	-		E1_KOG3789
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4771
Inparanoid	1	1.050	318	1.000	Inparanoid score	I2518
OMA	1	1.010	-	-		QHG55115
OrthoDB	1	1.010	-	-		D500740at2759
OrthoFinder	1	1.000	-	-		FOG0005663
OrthoInspector	1	1.000	-	-		oto41666
orthoMCL	1	0.900	-	-		OOG6_103955
Panther	1	1.100	-	-	LDO	PTHR12991
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R837
SonicParanoid	1	1.000	-	-		X4639
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800