DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nprl2 and NPRL2

DIOPT Version :9

Sequence 1:	NP_573174.1	Gene:	Nprl2 / 32677	FlyBaseID:	FBgn0030800	Length:	412	Species:	Drosophila melanogaster
Sequence 2:	NP_006536.3	Gene:	NPRL2 / 10641	HGNCID:	24969	Length:	380	Species:	Homo sapiens

Alignment Length:	392	Identity:	176/392 - (44%)
Similarity:	253/392 - (64%)	Gaps:	16/392 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 GSGAGAAGAHGSTEGKIRCIFLSEFHATAGCKISCQVPDNYISKDVFDAINVYIIPKQHLQRCIL 88
            |||.           :|.|||.||||.|.|.||:.|||:::||:::||.:.||||.|..||..::
Human     2 GSGC-----------RIECIFFSEFHPTLGPKITYQVPEDFISRELFDTVQVYIITKPELQNKLI 55

  Fly    89 TVNAMDVKIVGYPVGIQDQQKYARNAFLFNLCFVCDSRARSVQYEPVVKKLSEYLIMMEEESCFL 153
            ||.||:.|::|.||.| :.:||:|||.||||.||||::|::...||:||||:.||..:|.||.|:
Human    56 TVTAMEKKLIGCPVCI-EHKKYSRNALLFNLGFVCDAQAKTCALEPIVKKLAGYLTTLELESSFV 119

  Fly   154 SREDDKRRLQNIFETVLRDLNERKVATI-VEGDNTIYLKIVMHKPDPPPVKDHMVPLLLANLRDA 217
            |.|:.|::|..|...:|.:||.....|: ::..|||:||::..:||||..:::.||:...:..|.
Human   120 SMEESKQKLVPIMTILLEELNASGRCTLPIDESNTIHLKVIEQRPDPPVAQEYDVPVFTKDKEDF 184

  Fly   218 PLDNWDLTTQQILPYINGINHVARIAAEADVETDLVKSCIQNLVYYGVVQLLPILKYSNVYM-TQ 281
            ....||||||||||||:|..|:.:|:||||||.:||:..||||:|||||.|:.||:|||||. |.
Human   185 FNSQWDLTTQQILPYIDGFRHIQKISAEADVELNLVRIAIQNLLYYGVVTLVSILQYSNVYCPTP 249

  Fly   282 NLKHLIQSASLSGACRKYVALRPDKTLPSVQRIFQFYASMTHGVTLRAICQRLCPQHHNIDERRM 346
            .::.|:...||..||..||..:..|. .|::.:||.|.|::.|.|:|.:..|...|..::|||::
Human   250 KVQDLVDDKSLQEACLSYVTKQGHKR-ASLRDVFQLYCSLSPGTTVRDLIGRHPQQLQHVDERKL 313

  Fly   347 VIFGLQHRFIRCIHKYPV-FTGSVPSGRQKMYTGLISFDEICCKTGLSPCTIERDIEKDTNVTVI 410
            :.|||....||.:.|||| .|....|...::|||..|:||||||||:|...::..:|.|.|:.:.
Human   314 IQFGLMKNLIRRLQKYPVRVTREEQSHPARLYTGCHSYDEICCKTGMSYHELDERLENDPNIIIC 378

  Fly   411 WK 412
            ||
Human   379 WK 380

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nprl2	NP_573174.1	NPR3	40..403	CDD:305178	168/365 (46%)
NPRL2	NP_006536.3	Interaction with PDPK1. /evidence=ECO:0000269\|PubMed:18616680	1..133		69/142 (49%)
NPRL2	NP_006536.3	NPR3	7..370	CDD:420157	168/364 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158917
Domainoid	1	1.000	254	1.000	Domainoid score	I2069
eggNOG	1	0.900	-	-		E1_KOG3789
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4771
Inparanoid	1	1.050	332	1.000	Inparanoid score	I2434
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55115
OrthoDB	1	1.010	-	-		D500740at2759
OrthoFinder	1	1.000	-	-		FOG0005663
OrthoInspector	1	1.000	-	-		oto89245
orthoMCL	1	0.900	-	-		OOG6_103955
Panther	1	1.100	-	-	LDO	PTHR12991
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R837
SonicParanoid	1	1.000	-	-		X4639
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800