Protein Alignment RSG7 and RGS6

DIOPT Version :10

• Sequence 1: NP_523380.2
• Gene: RSG7 / 32674
• FlyBaseID: FBgn0024941
• Length: 647
• Species: Drosophila melanogaster
• Sequence 2: XP_024305527.1
• Gene: RGS6 / 9628
• HGNCID: 10002
• Length: 684
• Species: Homo sapiens
• Alignment Length: 445
• Identity: 246/445 - (55%)
• Similarity: 322/445 - (72%)
• Gaps: 25/445 - (5%)

  Fly   209 EDAPNILVYKKMEAIIEKMQAEST-GVAVRTVKAFMSKVPSVFTGADLVAWILKNFDVEDVTEAL 272
            |.:||::||.|:|.||.|||.:.| ||.:||||:|:||:|||.||.|:|.|::||..:||..||:
Human    18 ESSPNMIVYCKIEDIITKMQDDKTGGVPIRTVKSFLSKIPSVVTGTDIVQWLMKNLSIEDPVEAI 82

  Fly   273 HFAHLLSSHGYIFPIDDHALTVKNDGTFYRFQTPYFWPSNCWEPENTDYAVYLCKRTMQNKTRLE 337
            |...|:::.||||||.||.||:|:||||||||.|||||||||||||||||:||||||||||.|||
Human    83 HLGSLIAAQGYIFPISDHVLTMKDDGTFYRFQAPYFWPSNCWEPENTDYAIYLCKRTMQNKARLE 147

  Fly   338 LADYEAENLAKLQKMFSRKWEFIFMQAESQSKVAKKRDKLERKVLDSQERAFWDVHRPMPGCVNT 402
            ||||||||||:||:.|:|||||||||||:|.|:.:|:||.|||:||||||||||||||:||||||
Human   148 LADYEAENLARLQRAFARKWEFIFMQAEAQVKIDRKKDKTERKILDSQERAFWDVHRPVPGCVNT 212

  Fly   403 TEIDIKKAYRRGG------SSHGTGSAGASLAKNPVEQLTRIIA------LRKQ------KLERR 449
            ||:||:|..|...      |.:|.  ...|.|::||..|::.|.      :|||      :::|.
Human   213 TEMDIRKCRRLKNPQKVKKSVYGV--TEESQAQSPVHVLSQPIRKTTKEDIRKQITFLNAQIDRH 275

  Fly   450 TIKVSKAAEALVAYYDQYNEFDYFITSPELPNPWQTDSTEMWDTEKNSKEVPVRRVKRWAFSLRE 514
            .:|:||.||:|:||.:||.|:|..||..|..|||.:|...:||.|. |||...:|||||.||..|
Human   276 CLKMSKVAESLIAYTEQYVEYDPLITPAEPSNPWISDDVALWDIEM-SKEPSQQRVKRWGFSFDE 339

  Fly   515 LLNDAIGREQFTKFLEKEYSGENLKFWESVQEMKALPQSEIKEAIQKIWQEFLAPEAPCPVNVDS 579
            :|.|.:||:||.:|||.|:|.|||:||.:||::|..|..::.:.:::||||||||.||..:|:||
Human   340 ILKDQVGRDQFLRFLESEFSSENLRFWLAVQDLKKQPLQDVAKRVEEIWQEFLAPGAPSAINLDS 404

  Fly   580 KSVELAREAVNSPSGPNRWCFDVAASHVYHLMKSDSYSRYLRSDMYKDYLNCSRK 634
            .|.|:..:.|..   ..|:.|:.|..|:|.|||||||:|:|||:.|:|.|...:|
Human   405 HSYEITSQNVKD---GGRYTFEDAQEHIYKLMKSDSYARFLRSNAYQDLLLAKKK 456

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RSG7	NP_523380.2	DEP_RGS7-like	222..309	CDD:239897	52/87 (60%)
		RGS_DHEX	306..407	CDD:375589	84/100 (84%)
		GGL	432..493	CDD:128520	27/72 (38%)
		RGS_R7-like	504..627	CDD:188660	61/122 (50%)
RGS6	XP_024305527.1	DEP_RGS7-like	31..119	CDD:239897	52/87 (60%)
		RGS_DHEX	116..217	CDD:375589	84/100 (84%)
		GGL	258..319	CDD:128520	24/60 (40%)
		RGS_RGS6	328..452	CDD:188691	62/126 (49%)