DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RSG7 and AXIN1

DIOPT Version :9

Sequence 1:	NP_001245722.1	Gene:	RSG7 / 32674	FlyBaseID:	FBgn0024941	Length:	647	Species:	Drosophila melanogaster
Sequence 2:	XP_011520984.1	Gene:	AXIN1 / 8312	HGNCID:	903	Length:	916	Species:	Homo sapiens

Alignment Length:	173	Identity:	40/173 - (23%)
Similarity:	68/173 - (39%)	Gaps:	49/173 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   482 PWQTDSTEMWDTEKNSKEVPVRRVKRWAFSLRELLNDAIGREQFTKFLEKEYSGENLKFWESVQE 546
            |.::|....::.|.::...|  ...:||.||..||:|..|...|..||::|...:.|.||.:...
Human   110 PRRSDLDLGYEPEGSASPTP--PYLKWAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTG 172

  Fly   547 MKALPQSEIKEAIQKIWQEFLAPEAPCPVNVDSKSVELARE-----------AVNSPSGPN---- 596
            .:.|                    .||..| :.|.::|||.           .|:..:.|.
Human   173 FRKL--------------------EPCDSN-EEKRLKLARAIYRKYILDNNGIVSRQTKPATKSF 216

  Fly   597 -RWC----------FDVAASHVYHLMKSDSYSRYLRSDMYKDY 628
             :.|          ||.|.:.:...|:.::|..:|:||:|.:|
Human   217 IKGCIMKQLIDPAMFDQAQTEIQATMEENTYPSFLKSDIYLEY 259

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RSG7	NP_001245722.1	DEP_RGS7-like	222..309	CDD:239897
		GGL	432..493	CDD:128520	2/10 (20%)
		RGS_R7-like	504..627	CDD:188660	35/148 (24%)
AXIN1	XP_011520984.1	Axin_TNKS_binding	60..129	CDD:211424	3/18 (17%)
		RGS_Axin	138..258	CDD:188662	32/140 (23%)
		Axin_b-cat_bind	518..574	CDD:285982
		DIX	836..911	CDD:279160
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3589
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810