DRSC/TRiP Functional Genomics Resources

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Protein Alignment RSG7 and RGS12

DIOPT Version :9

Sequence 1:NP_001245722.1 Gene:RSG7 / 32674 FlyBaseID:FBgn0024941 Length:647 Species:Drosophila melanogaster
Sequence 2:NP_001381083.1 Gene:RGS12 / 6002 HGNCID:9994 Length:1447 Species:Homo sapiens


Alignment Length:271 Identity:76/271 - (28%)
Similarity:126/271 - (46%) Gaps:51/271 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly   371 AKKRDKLERKVLDSQERAFWDVHRPMPGCVNTTEIDIKKAYRRGGSSHGTG--------SAGASL 427
            |.||: ..||....|  :.:..||.    |..|:.| ||..:.|   .|||        ||..|.
Human   597 APKRE-WSRKAFGMQ--SIFGPHRN----VRKTKED-KKGSKFG---RGTGLTQPSQRTSARRSF 650

  Fly   428 AKNPVEQLTRIIALRKQKLERRTIKVSKAAEALVAYYDQYNEFDYFITSPELPNPWQTD---STE 489
            .::....:||.:    ..||..|:.                  |..:|..:|.:....:   |..
Human   651 GRSKRFSITRSL----DDLESATVS------------------DGELTGADLKDCVSNNSLSSNA 693

  Fly   490 MWDTEKNSKEVPVRRVKRWAFSLRELLNDAIGREQFTKFLEKEYSGENLKFWESVQEMKALPQSE 554
            ...:.::.:.:..|||..||.|...||.|.:|...|:.||.||:|.||:.||::.:....:|..:
Human   694 SLPSVQSCRRLRERRVASWAVSFERLLQDPVGVRYFSDFLRKEFSEENILFWQACEYFNHVPAHD 758

  Fly   555 IKE---AIQKIWQEFLAPEAPCPVNVDSKSVELAREAVNSPSGPNRWCFDVAASHVYHLMKSDSY 616
            .||   ..::|:.:||..:|..|||:||:: :||.:.:.:|. |:  .|......:::|||.|||
Human   759 KKELSYRAREIFSKFLCSKATTPVNIDSQA-QLADDVLRAPH-PD--MFKEQQLQIFNLMKFDSY 819

  Fly   617 SRYLRSDMYKD 627
            :|:|:|.:|::
Human   820 TRFLKSPLYQE 830

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RSG7NP_001245722.1 DEP_RGS7-like 222..309 CDD:239897
GGL 432..493 CDD:128520 9/63 (14%)
RGS_R7-like 504..627 CDD:188660 46/125 (37%)
RGS12NP_001381083.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..21
PDZ_signaling 20..96 CDD:238492
PTB_RGS12 228..359 CDD:269984
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 410..429
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 443..482
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 618..652 12/41 (29%)
RGS_RGS12 716..830 CDD:188696 41/117 (35%)
RGS12_us1 836..949 CDD:406910
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 843..941
RBD1_RGS12 962..1031 CDD:340656
Ubiquitin_like_fold 1032..1104 CDD:421700
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1103..1169
RGS12_us2 1106..1180 CDD:406908
GoLoco 1188..1209 CDD:214645
RGS12_usC 1239..1376 CDD:406909
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1240..1447
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3589
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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