Protein Alignment RSG7 and RGS7

DIOPT Version :10

• Sequence 1: NP_523380.2
• Gene: RSG7 / 32674
• FlyBaseID: FBgn0024941
• Length: 647
• Species: Drosophila melanogaster
• Sequence 2: NP_001351815.1
• Gene: RGS7 / 6000
• HGNCID: 10003
• Length: 495
• Species: Homo sapiens
• Alignment Length: 450
• Identity: 247/450 - (54%)
• Similarity: 323/450 - (71%)
• Gaps: 20/450 - (4%)

  Fly   206 GKNEDAPNILVYKKMEAIIEKMQAESTGVAVRTVKAFMSKVPSVFTGADLVAWILKNFDVEDVTE 270
            |..:::||:|||:|||.:|.:||.|..|:.:||||:|:||:||||:|:|:|.|::||..:||..|
Human    13 GVADESPNMLVYRKMEDVIARMQDEKNGIPIRTVKSFLSKIPSVFSGSDIVQWLIKNLTIEDPVE 77

  Fly   271 ALHFAHLLSSHGYIFPIDDHALTVKNDGTFYRFQTPYFWPSNCWEPENTDYAVYLCKRTMQNKTR 335
            |||...|:::|||.|||.||.||:|:|||||||||||||||||||||||||||||||||||||.|
Human    78 ALHLGTLMAAHGYFFPISDHVLTLKDDGTFYRFQTPYFWPSNCWEPENTDYAVYLCKRTMQNKAR 142

  Fly   336 LELADYEAENLAKLQKMFSRKWEFIFMQAESQSKVAKKRDKLERKVLDSQERAFWDVHRPMPGCV 400
            |||||||||:||:||:.|:|||||||||||:|:||.|||||:|||:||||||||||||||:||||
Human   143 LELADYEAESLARLQRAFARKWEFIFMQAEAQAKVDKKRDKIERKILDSQERAFWDVHRPVPGCV 207

  Fly   401 NTTEIDIKKAYRRGG---------------SSHGTGSAGASLAKNPVE-QLTRIIALRKQKLERR 449
            ||||:||||:.|...               .||..........|.|.| :|.:.|...:.:|:|.
Human   208 NTTEVDIKKSSRMRNPHKTRKSVYGLQNDIRSHSPTHTPTPETKPPTEDELQQQIKYWQIQLDRH 272

  Fly   450 TIKVSKAAEALVAYYDQYNEFDYFITSPELPNPWQTDSTEMWDTEKNSKEVPVRRVKRWAFSLRE 514
            .:|:||.|::|::|.:||.|:|.|:..|:..|||.:|.|..|:.|. |||...:|||||.|.:.|
Human   273 RLKMSKVADSLLSYTEQYLEYDPFLLPPDPSNPWLSDDTTFWELEA-SKEPSQQRVKRWGFGMDE 336

  Fly   515 LLNDAIGREQFTKFLEKEYSGENLKFWESVQEMKALPQSEIKEAIQKIWQEFLAPEAPCPVNVDS 579
            .|.|.:|||||.||||.|:|.|||:||.:|:::|..|..|:...:|:||||||||.||..:|:||
Human   337 ALKDPVGREQFLKFLESEFSSENLRFWLAVEDLKKRPIKEVPSRVQEIWQEFLAPGAPSAINLDS 401

  Fly   580 KSVELAREAVNSPSGPNRWCFDVAASHVYHLMKSDSYSRYLRSDMYKDYLNCSRKKIKSI 639
            ||.:...:.|..   |.|:.|:.|..|:|.|||||||.|::||..|::.|...:|...|:
Human   402 KSYDKTTQNVKE---PGRYTFEDAQEHIYKLMKSDSYPRFIRSSAYQELLQAKKKSGNSM 458

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RSG7	NP_523380.2	DEP_RGS7-like	222..309	CDD:239897	51/86 (59%)
		RGS_DHEX	306..407	CDD:375589	87/100 (87%)
		GGL	432..493	CDD:128520	23/61 (38%)
		RGS_R7-like	504..627	CDD:188660	63/122 (52%)
RGS7	NP_001351815.1	DEP_RGS7-like	29..116	CDD:239897	51/86 (59%)
		RGS_DHEX	113..214	CDD:375589	87/100 (87%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	235..256		4/20 (20%)
		GGL	256..316	CDD:128520	22/59 (37%)
		RGS_RGS7	326..446	CDD:188692	63/122 (52%)