Protein Alignment RSG7 and RGS2

DIOPT Version :10

• Sequence 1: NP_523380.2
• Gene: RSG7 / 32674
• FlyBaseID: FBgn0024941
• Length: 647
• Species: Drosophila melanogaster
• Sequence 2: NP_002914.1
• Gene: RGS2 / 5997
• HGNCID: 9998
• Length: 211
• Species: Homo sapiens
• Alignment Length: 208
• Identity: 56/208 - (26%)
• Similarity: 98/208 - (47%)
• Gaps: 35/208 - (16%)

  Fly   442 RKQKLERRTIKVSKAAEALVAYYDQYNEFDYFITSPELPNPWQTDSTEMWDTEKNSKEVPV---- 502
            :::|::|..:|            |......||:.:...|...:|.        |.||:...
Human    29 KREKMKRTLLK------------DWKTRLSYFLQNSSTPGKPKTG--------KKSKQQAFIKPS 73

  Fly   503 -RRVKRWAFSLRELLNDAIGREQFTKFLEKEYSGENLKFWESVQEMKAL--PQSEIKEAIQKIWQ 564
             ...:.|:.:..|||....|...|..||:.|:..||::||.:.::.|..  || ::....:||:.
Human    74 PEEAQLWSEAFDELLASKYGLAAFRAFLKSEFCEENIEFWLACEDFKKTKSPQ-KLSSKARKIYT 137

  Fly   565 EFLAPEAPCPVNVDSKSVEL-AREAVNSPSGPNRWCFDVAASHVYHLMKSDSYSRYLRSDMYKDY 628
            :|:..|||..:|:|.::..| |:....:.||    ||..|...||.||:::||.|:|.|:.|:|.
Human   138 DFIEKEAPKEINIDFQTKTLIAQNIQEATSG----CFTTAQKRVYSLMENNSYPRFLESEFYQDL 198

  Fly   629 LNCSRKKIKSIPN 641
              |.:.:|.:.|:
Human   199 --CKKPQITTEPH 209

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RSG7	NP_523380.2	DEP_RGS7-like	222..309	CDD:239897
		RGS_DHEX	306..407	CDD:375589
		GGL	432..493	CDD:128520	8/50 (16%)
		RGS_R7-like	504..627	CDD:188660	41/125 (33%)
RGS2	NP_002914.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	14..33		0/3 (0%)
		Necessary for membrane association. /evidence=ECO:0000269|PubMed:11278586	32..66		10/53 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	49..68		5/26 (19%)
		Necessary to inhibit protein synthesis. /evidence=ECO:0000269|PubMed:19736320	79..116		13/36 (36%)
		RGS_RGS2	84..197	CDD:188664	40/117 (34%)