DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RSG7 and Rgs6

DIOPT Version :9

Sequence 1:	NP_001245722.1	Gene:	RSG7 / 32674	FlyBaseID:	FBgn0024941	Length:	647	Species:	Drosophila melanogaster
Sequence 2:	XP_011242435.1	Gene:	Rgs6 / 50779	MGIID:	1354730	Length:	552	Species:	Mus musculus

Alignment Length:	470	Identity:	248/470 - (52%)
Similarity:	325/470 - (69%)	Gaps:	33/470 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   183 AQPPQPPTATALAVPSASHHQRGGKNEDAPNILVYKKMEAIIEKMQAEST-GVAVRTVKAFMSKV 246
            ||......|..:|.|          .|.:||::||.|:|.||.|||.:.| ||.:||||:|:||:
Mouse     2 AQGSGDQRAVGIADP----------EESSPNMIVYCKIEDIITKMQDDKTGGVPIRTVKSFLSKI 56

  Fly   247 PSVFTGADLVAWILKNFDVEDVTEALHFAHLLSSHGYIFPIDDHALTVKNDGTFYRFQTPYFWPS 311
            |||.||.|:|.|::||..:||..||:|...|:::.||||||.||.||:|:||||||||.||||||
Mouse    57 PSVVTGTDIVQWLMKNLSIEDPVEAIHLGSLIAAQGYIFPISDHVLTMKDDGTFYRFQAPYFWPS 121

  Fly   312 NCWEPENTDYAVYLCKRTMQNKTRLELADYEAENLAKLQKMFSRKWEFIFMQAESQSKVAKKRDK 376
            |||||||||||:||||||||||.|||||||||||||:||:.|:|||||||||||:|.|:.:|:||
Mouse   122 NCWEPENTDYAIYLCKRTMQNKARLELADYEAENLARLQRAFARKWEFIFMQAEAQVKIDRKKDK 186

  Fly   377 LERKVLDSQERAFWDVHRPMPGCVNTTEIDIKKAYR-----------RGGSSHGTGSAGASLAKN 430
            .|||:||||||||||||||:||||||||:||:|..|           .|.:......:...:...
Mouse   187 TERKILDSQERAFWDVHRPVPGCVNTTEMDIRKCRRLKNPQKVKKSVYGVTDETQSQSPVHIPSQ 251

  Fly   431 PVEQLTRIIALRKQ------KLERRTIKVSKAAEALVAYYDQYNEFDYFITSPELPNPWQTDSTE 489
            |:.:.|: ..:|||      :::|..:|:||.||:|:||.:||.|:|.|||..|..|||.:|...
Mouse   252 PIRKTTK-DDIRKQITFLNAQIDRHCLKMSKVAESLIAYTEQYVEYDPFITPAEPSNPWISDDIT 315

  Fly   490 MWDTEKNSKEVPVRRVKRWAFSLRELLNDAIGREQFTKFLEKEYSGENLKFWESVQEMKALPQSE 554
            :||.|. |||...:|||||.||..|:|.|.:||:||.:|||.|:|.|||:||.|||::|..|..:
Mouse   316 LWDIEM-SKEPSQQRVKRWGFSFDEILKDQVGRDQFLRFLESEFSSENLRFWLSVQDLKKQPLQD 379

  Fly   555 IKEAIQKIWQEFLAPEAPCPVNVDSKSVELAREAVNSPSGPNRWCFDVAASHVYHLMKSDSYSRY 619
            :.:.:::||||||||.||..:|:||.|.|:..:.|..   ..|:.|:.|..|:|.|||||||:|:
Mouse   380 VAKRVEEIWQEFLAPGAPSAINLDSHSYEITSQNVKD---GGRYTFEDAQEHIYKLMKSDSYARF 441

  Fly   620 LRSDMYKDYLNCSRK 634
            |||:.|:|.|...:|
Mouse   442 LRSNAYQDLLLAKKK 456

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RSG7	NP_001245722.1	DEP_RGS7-like	222..309	CDD:239897	52/87 (60%)
		GGL	432..493	CDD:128520	26/66 (39%)
		RGS_R7-like	504..627	CDD:188660	62/122 (51%)
Rgs6	XP_011242435.1	DEP_RGS7-like	31..119	CDD:239897	52/87 (60%)
		RGS_DHEX	116..217	CDD:375589	84/100 (84%)
		GGL	258..319	CDD:128520	25/61 (41%)
		RGS_RGS6	328..452	CDD:188691	63/126 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	202	1.000	Domainoid score	I2979
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	516	1.000	Inparanoid score	I1274
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47957
OrthoDB	1	1.010	-	-		D201579at33208
OrthoFinder	1	1.000	-	-		FOG0002864
OrthoInspector	1	1.000	-	-		otm43362
orthoMCL	1	0.900	-	-		OOG6_101587
Panther	1	1.100	-	-	LDO	PTHR45746
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2506
SonicParanoid	1	1.000	-	-		X1899
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.010