DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RSG7 and Axn

DIOPT Version :9

Sequence 1:	NP_001245722.1	Gene:	RSG7 / 32674	FlyBaseID:	FBgn0024941	Length:	647	Species:	Drosophila melanogaster
Sequence 2:	NP_733336.1	Gene:	Axn / 43565	FlyBaseID:	FBgn0026597	Length:	745	Species:	Drosophila melanogaster

Alignment Length:	543	Identity:	107/543 - (19%)
Similarity:	181/543 - (33%)	Gaps:	190/543 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 ADKTQATNASSTAAPAKTDCTSSNSSDPLAVAIPEPQSATA------VVGGGA---------GGA 57
            |.:.:.|::.:|.:.:.....|..||...|.|:| |.:|:.      :|..||         .|.
  Fly   177 AQQERCTSSGATGSGSAGSSGSGGSSLAGACALP-PTTASGKQQLPQLVPPGAFINLPVSSVSGP 240

  Fly    58 APGTAT-------PSPTPLANGSNNGTG----SSVSP-----------------------AATGT 88
            ..||.:       ||.:..::||.:.|.    ||..|                       .:.|:
  Fly   241 PAGTCSASGSVYGPSTSASSSGSISATDTLPRSSTLPTLHEDSVLSLCDDFEKVQMQEGGGSLGS 305

  Fly    89 GAVATAASAP-------------AAAGTTSASPPAS-----NPTTASTSTA--SVVGAKTAAATT 133
            |:|...|.||             .........||.:     ||:|.:||..  |.|.::.|   :
  Fly   306 GSVGAGARAPDYPIRLTRDLLIATQKRRLEIRPPGAHGYVYNPSTTNTSYVPNSRVDSERA---S 367

  Fly   134 TSSSSATSSSTAAAGSKQSGSSGGLLTVSGNHH-HHHHAHPQQSAAGQSAAQPPQPPTATALAVP 197
            .||...|.|.|.:..|         .::.|..: ...|:..:..|..|||....:  |.|...:|
  Fly   368 VSSGGRTDSDTMSISS---------CSMDGRPYIQRRHSSTESKAIRQSAMANKE--TNTFQVIP 421

  Fly   198 SA----SHHQRGGKNEDAPNILV-----YKKMEAIIEKMQAESTGVAVRT-------VKAFMSKV 246
            ..    |:..|..|.|:..::|:     .|:...:.|:.:..:.|.|:.|       .:||...:
  Fly   422 RTQRLHSNEHRPLKEEELVSLLIPKLEEVKRKRDLEERARERNPGAALLTNERSSASDRAFAEAI 486

  Fly   247 PSVFTGADLVAWILKNFDVEDVTEALHFAHLLSSHGYIFPIDDHALTVKNDGTFYRFQTPYFWP- 310
            ...|.        |...:.:|:                  :|.|...|..|      |||:..|
  Fly   487 REKFA--------LDEDNDQDI------------------LDQHVSRVWKD------QTPHRSPG 519

  Fly   311 --SNCWE-PEN-----------TDYAVYL----------------CKRTMQNK-----TRLELAD 340
              |.|.. |..           :|.|:.|                |.|.:.||     |...::.
  Fly   520 TMSPCPPIPSRRRTATHDSGMVSDGAMSLSGHSMKHSKSMPDHSSCSRKLTNKWPSMNTDSGISM 584

  Fly   341 YEAENLAKLQKMFSRKWEFIFMQAESQSKVAKKRDKLERKVLDSQERAFWDVHRPMPGCVNTTEI 405
            :.|:.:.|.:...||          |.|..|.|.::.:|::.|...|:......||
  Fly   585 FSADTVTKYKDASSR----------SGSSTASKLEEAKRRLEDEPRRSRRYAQPPM--------- 630

  Fly   406 DIKKAYRRGGSSHGTGSAGASLA 428
              :...::..:|..:.|:|.|::
  Fly   631 --QHLSQQPLASFSSSSSGGSIS 651

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RSG7	NP_001245722.1	DEP_RGS7-like	222..309	CDD:239897	16/93 (17%)
		GGL	432..493	CDD:128520
		RGS_R7-like	504..627	CDD:188660
Axn	NP_733336.1	RGS	55..170	CDD:295367
		Axin_b-cat_bind	494..543	CDD:285982	12/72 (17%)
		DIX	665..739	CDD:279160
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3589
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810