DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RSG7 and loco

DIOPT Version :9

Sequence 1:	NP_001245722.1	Gene:	RSG7 / 32674	FlyBaseID:	FBgn0024941	Length:	647	Species:	Drosophila melanogaster
Sequence 2:	NP_732773.1	Gene:	loco / 42672	FlyBaseID:	FBgn0020278	Length:	1541	Species:	Drosophila melanogaster

Alignment Length:	677	Identity:	146/677 - (21%)
Similarity:	220/677 - (32%)	Gaps:	240/677 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 PEPQSATAVVGGGAGGAAPG---TATPSPTP--------LANGSNNGTGSS------------VS 82
            |..:|..|....|||.||.|   .|..||.|        ..:.|::|.|.:            |.
  Fly   429 PASRSHQADYEAGAGAAAAGGAVAAAHSPQPSNHSEISTTTSNSDSGIGFNNDCTNISDRILVVD 493

  Fly    83 PAATGTGAVATAASAP----------------------AAAGTTSA---SPPAS----------- 111
            ..|.|.||.|.|.:.|                      .|....||   |||||
  Fly   494 FLAAGAGAAAAAHAGPPTYPAPARPLGIVGIPDNRLTVRAMPDHSALLRSPPASSSLRRPNLLAS 558

  Fly   112 -----NPTTASTSTASV---------VGAKTAAATTTSSSSATSSSTAAAGSKQSGSSGGLLTVS 162
                 :|.|..|||.|.         ...:|.||..:....:..|   ||.|...|
  Fly   559 FNLIQSPATNLTSTRSCDDVLNLFVDDSPRTLAAVASMDDISLHS---AAPSLDEG--------- 611

  Fly   163 GNHHHHHHAHPQQSAAGQSAAQPPQPPTATALAVPSASHHQRGGKNEDAPNILVYKKMEAIIEKM 227
                 |..|||        |..|.:...:.||..|:..|                 |:.|.:...
  Fly   612 -----HTFAHP--------ACVPRKMRRSLALETPTTPH-----------------KLSAQVFGQ 646

  Fly   228 QAESTGVAVRTVKAFMSKVPSVFTGADLVAWI-LKNFDVEDVTEALHFAHLLSSHGYIFPIDDHA 291
            ......:....:.:..|.|........:..|. |:|         ||.:|.          |..:
  Fly   647 PGSRHSLGFEAIDSVQSSVSGACMDQTMDTWASLQN---------LHKSHK----------DRTS 692

  Fly   292 LTVKNDGTFYRFQTPYFWPSNC-WEPENTDYAVYLCKRTMQNKTRLELADYEAENLAKLQKMFSR 355
            ::..:.             |:| .|..|::                  .|.....|......|.|
  Fly   693 MSASSS-------------SHCLLEATNSE------------------PDLGNRALPANASPFRR 726

  Fly   356 KWEFIFMQAESQSKVAKKRDKLERKVLDSQERAFWDVHRPMPGCVNTTEIDIKKAYRRGGSS--H 418
            .|.....:.....||||::.:|                                    |.||  .
  Fly   727 AWGQSSFRTPRSDKVAKEQQQL------------------------------------GQSSPVR 755

  Fly   419 GTGSAGASLAKNPVEQLTRIIALRKQKLERR--TIKVSKAAEALVAYYDQYNEFDYFITSPELPN 481
            .|.|..||.....::.|.....|:..:.:.:  .::|.|.                 :|:|..|:
  Fly   756 RTASMNASDNDMYIKTLMLDSDLKSSRSQHQLSLLQVPKV-----------------LTTPAPPS 803

  Fly   482 PWQTDSTEMWDTEKNSKE--VPVRRVKRWAFSLRELLNDAIGREQFTKFLEKEYSGENLKFWESV 544
            .    .|.....|..:::  .|    ..||.|...:|.||.|.:.|::||:||:|.||:.||.:.
  Fly   804 A----ITASVAAEGAAQDHGCP----SSWAGSFERMLQDAAGMQTFSEFLKKEFSAENIYFWTAC 860

  Fly   545 QEMKALPQSEIKEAIQ--KIWQEFLAPEAPCPVNVDSKSVELAREAVNSPSGPNRWCFDVAASHV 607
            :..:.| :||.....|  :|:.:.||..:..||||||::..|..|.: :.:.|:  .|..|...:
  Fly   861 ERYRLL-ESEADRVAQAREIFAKHLANNSSDPVNVDSQARSLTEEKL-ADAAPD--IFAPAQKQI 921

  Fly   608 YHLMKSDSYSRYLRSDMYKDYLNCSRK 634
            :.|||.|||.|::|||:||..:...:|
  Fly   922 FSLMKFDSYQRFIRSDLYKSCVEAEQK 948

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RSG7	NP_001245722.1	DEP_RGS7-like	222..309	CDD:239897	10/87 (11%)
		GGL	432..493	CDD:128520	8/62 (13%)
		RGS_R7-like	504..627	CDD:188660	46/124 (37%)
loco	NP_732773.1	PDZ_signaling	69..145	CDD:238492
		PTB_RGS12	251..391	CDD:269984
		RGS_R12-like	828..941	CDD:188661	43/116 (37%)
		RGS12_RBD	1073..1145	CDD:176412
		RBD	1144..1213	CDD:128731
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45439815
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3589
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740