DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RSG7 and Rgs9

DIOPT Version :9

Sequence 1:	NP_001245722.1	Gene:	RSG7 / 32674	FlyBaseID:	FBgn0024941	Length:	647	Species:	Drosophila melanogaster
Sequence 2:	NP_035398.2	Gene:	Rgs9 / 19739	MGIID:	1338824	Length:	675	Species:	Mus musculus

Alignment Length:	427	Identity:	163/427 - (38%)
Similarity:	248/427 - (58%)	Gaps:	33/427 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   212 PNILVYKKMEAIIEKMQAESTGVAVRTVKAFMSKVPSVFTGADLVAWILKNFDVEDVTEALHFAH 276
            |.:...:|:||:::.||...|||.:...:..::.||...||.|::.||.:...:.:: ||.:..:
Mouse    12 PRMAFLQKIEALVKDMQNPETGVRMHNQRVLVTSVPHAMTGGDVLQWITQRLWISNL-EAQNLGN 75

  Fly   277 LLSSHGYIFPIDD-HALTVKNDGTFYRFQTPYFWPSNCWEPENTDYAVYLCKRTMQNKTRLELAD 340
            .:..:|||:|:.| ..|.:|.|.:.||||||||||:..|..|:||||:||.||.::.|..||  :
Mouse    76 FIVKYGYIYPLQDPKNLILKPDSSLYRFQTPYFWPTQQWPAEDTDYAIYLAKRNIKKKGILE--E 138

  Fly   341 YEAENLAKLQKMFSRKWEFIFMQAESQSKVAKKRDKLERKVLDSQERAFWDVHRPMPGCVNTTEI 405
            ||.||...|.|..:.||:|:.|||:.|.:..|:|:|.:|..||.||:|:|.|||..||..|..:.
Mouse   139 YEKENYDFLNKKINYKWDFVIMQAKEQYRTGKERNKADRYALDCQEKAYWLVHRSPPGMNNVLDY 203

  Fly   406 DIKKAYRRGGSSHGTGSAGASLAKNPVE-QLTRIIALRK------QKLERRTIKVSKAAEALVAY 463
                              |.....||.| :...:.|:||      |.|.|.|:|.|.:...:|.|
Mouse   204 ------------------GLDRVTNPNEVKKQTVTAVRKEIMYYQQALMRSTVKSSVSLGGIVKY 250

  Fly   464 YDQYNEFDYFITSPELPNPWQTDSTEMWDTEKNSKEVPVR-RVKRWAFSLRELLNDAIGREQFTK 527
            .:|::..|..::.....|||.||.|:.||......|:|.: ||:||||:..||:.|..||:.|..
Mouse   251 SEQFSSNDAIMSGCLPSNPWITDDTQFWDLNAKLVEIPTKMRVERWAFNFSELIRDPKGRQSFQY 315

  Fly   528 FLEKEYSGENLKFWESVQEMKALPQSEIKEAIQKIWQEFLAPEAPCPVNVDSKSVELAREAVNSP 592
            ||:||:|||||.|||:.:::|...||::||..::|::.||||.|...:|:|.|::::   .|...
Mouse   316 FLKKEFSGENLGFWEACEDLKYGDQSKVKEKAEEIYKLFLAPGARRWINIDGKTMDI---TVKGL 377

  Fly   593 SGPNRWCFDVAASHVYHLMKSDSYSRYLRSDMYKDYL 629
            ..|:|:..|.|.:|:|.|||.|||:|||:|.:||:.|
Mouse   378 RHPHRYVLDAAQTHIYMLMKKDSYARYLKSPIYKEML 414

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RSG7	NP_001245722.1	DEP_RGS7-like	222..309	CDD:239897	30/87 (34%)
		GGL	432..493	CDD:128520	21/67 (31%)
		RGS_R7-like	504..627	CDD:188660	56/122 (46%)
Rgs9	NP_035398.2	DEP_RGS7-like	22..109	CDD:239897	30/87 (34%)
		GGL	219..280	CDD:128520	20/60 (33%)
		RGS_RGS9	292..412	CDD:188693	56/122 (46%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	524..571
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	637..662
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3589
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D201579at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101587
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.720