DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RSG7 and Rgs2

DIOPT Version :9

Sequence 1:	NP_001245722.1	Gene:	RSG7 / 32674	FlyBaseID:	FBgn0024941	Length:	647	Species:	Drosophila melanogaster
Sequence 2:	NP_033087.2	Gene:	Rgs2 / 19735	MGIID:	1098271	Length:	211	Species:	Mus musculus

Alignment Length:	205	Identity:	59/205 - (28%)
Similarity:	100/205 - (48%)	Gaps:	29/205 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   442 RKQKLERRTIKVSKAAEALVAYYDQYNEFDYFITSPELPNPWQTDSTEMWDT-EKNSKEVPVRRV 505
            :::|::|..:|            |......||:.:...|...:|.......| .|.|.|    ..
Mouse    29 KREKMKRTLLK------------DWKTRLSYFLQNSSAPGKPKTGKKSKQQTFIKPSPE----EA 77

  Fly   506 KRWAFSLRELLNDAIGREQFTKFLEKEYSGENLKFWESVQEMKAL--PQSEIKEAIQKIWQEFLA 568
            :.||.:..|||....|...|..||:.|:..||::||.:.::.|..  || ::....:||:.:|:.
Mouse    78 QLWAEAFDELLASKYGLAAFRAFLKSEFCEENIEFWLACEDFKKTKSPQ-KLSSKARKIYTDFIE 141

  Fly   569 PEAPCPVNVD--SKSVELAREAVNSPSGPNRWCFDVAASHVYHLMKSDSYSRYLRSDMYKDYLNC 631
            .|||..:|:|  :||: :|:....:.||    ||..|...||.||:::||.|:|.|:.|:|.  |
Mouse   142 KEAPKEINIDFQTKSL-IAQNIQEATSG----CFTTAQKRVYSLMENNSYPRFLESEFYQDL--C 199

  Fly   632 SRKKIKSIPN 641
            .:.:|.:.|:
Mouse   200 KKPQITTEPH 209

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RSG7	NP_001245722.1	DEP_RGS7-like	222..309	CDD:239897
		GGL	432..493	CDD:128520	8/50 (16%)
		RGS_R7-like	504..627	CDD:188660	43/126 (34%)
Rgs2	NP_033087.2	Necessary for membrane association. /evidence=ECO:0000250\|UniProtKB:P41220	32..66		8/45 (18%)
		Necessary to inhibit protein synthesis. /evidence=ECO:0000250\|UniProtKB:P41220	79..116		14/36 (39%)
		RGS_RGS2	84..197	CDD:188664	41/118 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3589
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810