DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RSG7 and Axin2

DIOPT Version :9

Sequence 1:	NP_001245722.1	Gene:	RSG7 / 32674	FlyBaseID:	FBgn0024941	Length:	647	Species:	Drosophila melanogaster
Sequence 2:	NP_056547.3	Gene:	Axin2 / 12006	MGIID:	1270862	Length:	840	Species:	Mus musculus

Alignment Length:	179	Identity:	39/179 - (21%)
Similarity:	73/179 - (40%)	Gaps:	35/179 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   475 TSPELPNPWQTDSTEMWDTEKNSKE------------VPVRRVKRWAFSLRELLNDAIGREQFTK 527
            |.|..|:..:..||:......|::.            .|...:.||..||..||.|..|...|..
Mouse    33 TPPCQPSVGKVQSTKPMPVSSNARRNEDGLGEPEGRASPDSPLTRWTKSLHSLLGDQDGAYLFRT 97

  Fly   528 FLEKEYSGENLKFWESVQEMKALPQSEIK--EAIQKIWQEFLAPEAPCPVNVDSKSVE------- 583
            |||:|...:.|.||.:....:.:...:.|  ...:.|::.::...     :|.||.::
Mouse    98 FLEREKCVDTLDFWFACNGFRQMNLKDTKTLRVAKAIYKRYIENN-----SVVSKQLKPATKTYI 157

  Fly   584 ---LAREAVNSPSGPNRWCFDVAASHVYHLMKSDSYSRYLRSDMYKDYL 629
               :.::.:.|.      .||.|.:.:..:|:.::|..:|.||:|.:|:
Mouse   158 RDGIKKQQIGSV------MFDQAQTEIQAVMEENAYQVFLTSDIYLEYV 200

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RSG7	NP_001245722.1	DEP_RGS7-like	222..309	CDD:239897
		GGL	432..493	CDD:128520	5/17 (29%)
		RGS_R7-like	504..627	CDD:188660	31/134 (23%)
Axin2	NP_056547.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..75		7/41 (17%)
		AXIN1_TNKS_BD	10..73	CDD:374700	7/39 (18%)
		Tankyrase-binding motif	21..30
		RGS_Axin	82..198	CDD:188662	28/126 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	300..363
		Interaction with GSK3B. /evidence=ECO:0000250	327..413
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	398..435
		Interaction with beta-catenin. /evidence=ECO:0000250	413..478
		Axin_b-cat_bind	432..467	CDD:370146
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	447..485
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	572..614
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	715..745
		DAX	758..840	CDD:197474
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3589
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810