DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RSG7 and Axin1

DIOPT Version :9

Sequence 1:	NP_001245722.1	Gene:	RSG7 / 32674	FlyBaseID:	FBgn0024941	Length:	647	Species:	Drosophila melanogaster
Sequence 2:	NP_001381310.1	Gene:	Axin1 / 12005	MGIID:	1096327	Length:	863	Species:	Mus musculus

Alignment Length:	162	Identity:	37/162 - (22%)
Similarity:	72/162 - (44%)	Gaps:	27/162 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   482 PWQTDSTEMWDTEKNSKEVPVRRVKRWAFSLRELLNDAIGREQFTKFLEKEYSGENLKFWESVQE 546
            |.::|....::.|.::...|  ...|||.||..||:|..|...|..||::|...:.|.||.:...
Mouse    61 PRRSDLDLGYEPEGSASPTP--PYLRWAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACSG 123

  Fly   547 MKALPQSEIKE-----AIQKIWQEFLAPEAPCPVNVDSKSVELAREAVNSPSGPNRWC------- 599
            .:.|...:..|     ..:.|:::::         :||..: ::|:...:.....:.|
Mouse   124 FRKLEPCDSNEEKRLKLARAIYRKYI---------LDSNGI-VSRQTKPATKSFIKDCVMKQQID 178

  Fly   600 ---FDVAASHVYHLMKSDSYSRYLRSDMYKDY 628
               ||.|.:.:...|:.::|..:|:||:|.:|
Mouse   179 PAMFDQAQTEIQSTMEENTYPSFLKSDIYLEY 210

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RSG7	NP_001245722.1	DEP_RGS7-like	222..309	CDD:239897
		GGL	432..493	CDD:128520	2/10 (20%)
		RGS_R7-like	504..627	CDD:188660	32/137 (23%)
Axin1	NP_001381310.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..81		4/21 (19%)
		Axin_TNKS_binding	11..80	CDD:211424	3/18 (17%)
		Tankyrase-binding motif	20..29
		RGS_Axin	89..209	CDD:188662	28/129 (22%)
		Interaction with TP53. /evidence=ECO:0000269\|PubMed:15526030	209..338		1/2 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	215..240
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	249..268
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	315..344
		Interaction with GSK3B. /evidence=ECO:0000250	348..432
		Interaction with beta-catenin. /evidence=ECO:0000250	433..501
		Axin_b-cat_bind	464..495	CDD:400956
		Interaction with RNF111. /evidence=ECO:0000250	505..758
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	529..624
		Interaction with PPP2CA. /evidence=ECO:0000250	572..790
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	642..664
		Interaction with HIPK2. /evidence=ECO:0000269\|PubMed:15526030	678..753
		DIX	783..860	CDD:395628
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3589
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810