DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RSG7 and rgs6

DIOPT Version :9

Sequence 1:	NP_001245722.1	Gene:	RSG7 / 32674	FlyBaseID:	FBgn0024941	Length:	647	Species:	Drosophila melanogaster
Sequence 2:	XP_004917305.1	Gene:	rgs6 / 100486845	XenbaseID:	XB-GENE-954519	Length:	489	Species:	Xenopus tropicalis

Alignment Length:	467	Identity:	247/467 - (52%)
Similarity:	327/467 - (70%)	Gaps:	33/467 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   187 QPPTATALAVPSASHHQRGGKNEDAPNILVYKKMEAIIEKMQAEST-GVAVRTVKAFMSKVPSVF 250
            |....:.:.||.        ..::.||::||:|:|.||.:||.:.. ||.:||||:|:||:|||.
Frog     3 QSSDTSVVGVPD--------PEDNTPNMIVYRKIEDIITRMQDDKAGGVPIRTVKSFLSKIPSVV 59

  Fly   251 TGADLVAWILKNFDVEDVTEALHFAHLLSSHGYIFPIDDHALTVKNDGTFYRFQTPYFWPSNCWE 315
            ||||:|.|::||.::||..||:|...|:::.||||||.||.||:|:||||||||.||||||||||
Frog    60 TGADIVQWLVKNLNIEDPAEAIHLGSLIAAQGYIFPISDHVLTLKDDGTFYRFQAPYFWPSNCWE 124

  Fly   316 PENTDYAVYLCKRTMQNKTRLELADYEAENLAKLQKMFSRKWEFIFMQAESQSKVAKKRDKLERK 380
            |||||||:||||||||||.|||||||||||||:||:.|:|||||||||||:|.|:.:|:||.|||
Frog   125 PENTDYAIYLCKRTMQNKARLELADYEAENLARLQRAFARKWEFIFMQAEAQVKIDRKKDKTERK 189

  Fly   381 VLDSQERAFWDVHRPMPGCVNTTEIDIKKAYRRGG------SSHGTGSAGASLAKNPVEQLTRII 439
            :||||||.|||||||:||||||||:||:|..|...      |.:|...  .|.:::||...:.:|
Frog   190 ILDSQERGFWDVHRPVPGCVNTTEMDIRKCRRMKNPQKVKKSVYGVSE--DSQSQSPVHMASHVI 252

  Fly   440 A------LRKQ------KLERRTIKVSKAAEALVAYYDQYNEFDYFITSPELPNPWQTDSTEMWD 492
            .      ||||      :::|..:|:||.|::.:|:.:||.|:|.|:|.||..|||.:|.|...|
Frog   253 RKTTKDDLRKQINFLNVQIDRHCLKMSKVADSFIAFTEQYTEYDPFLTPPEPSNPWISDDTTFLD 317

  Fly   493 TEKNSKEVPVRRVKRWAFSLRELLNDAIGREQFTKFLEKEYSGENLKFWESVQEMKALPQSEIKE 557
            .| ||||...:|||||.|||.|:|.|.:|||||.:|||.|:|.|||:||..||::|..|..|:.:
Frog   318 LE-NSKEPSQQRVKRWGFSLDEVLKDPVGREQFLRFLESEFSSENLRFWVVVQDLKKQPLHEVPK 381

  Fly   558 AIQKIWQEFLAPEAPCPVNVDSKSVELAREAVNSPSGPNRWCFDVAASHVYHLMKSDSYSRYLRS 622
            .:::||||||||.|...:|:||.|.|...:.|..   |.|:.|:.|..|:|.|||||||:|:|||
Frog   382 RVEEIWQEFLAPGAQSAINLDSHSFEKTSQNVKD---PGRYTFEDAQEHIYKLMKSDSYARFLRS 443

  Fly   623 DMYKDYLNCSRK 634
            :.|:|.|...:|
Frog   444 NAYQDLLLMKKK 455

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RSG7	NP_001245722.1	DEP_RGS7-like	222..309	CDD:239897	51/87 (59%)
		GGL	432..493	CDD:128520	25/72 (35%)
		RGS_R7-like	504..627	CDD:188660	64/122 (52%)
rgs6	XP_004917305.1	DEP_RGS7-like	30..118	CDD:239897	51/87 (59%)
		RGS_DHEX	115..216	CDD:375589	83/100 (83%)
		GGL	257..318	CDD:128520	23/60 (38%)
		RGS_RGS6	327..451	CDD:188691	65/126 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	196	1.000	Domainoid score	I3078
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	500	1.000	Inparanoid score	I1335
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D201579at33208
OrthoFinder	1	1.000	-	-		FOG0002864
OrthoInspector	1	1.000	-	-		oto103754
Panther	1	1.100	-	-	LDO	PTHR45746
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1899
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.160