DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4829 and GGT5

DIOPT Version :9

Sequence 1:	NP_728030.2	Gene:	CG4829 / 32672	FlyBaseID:	FBgn0030796	Length:	822	Species:	Drosophila melanogaster
Sequence 2:	XP_011528435.1	Gene:	GGT5 / 2687	HGNCID:	4260	Length:	623	Species:	Homo sapiens

Alignment Length:	603	Identity:	188/603 - (31%)
Similarity:	291/603 - (48%)	Gaps:	87/603 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   287 YQHGAVSSDNLECSKIGSGILQKNGSAVDAAIAALLCNGLLTLQSMGIGGGHLMNVYNRKERHAT 351
            :.|.||::|:..||.||..|||:.||.|||.||||:|..::..||||:|||.:..:||.......
Human    41 FAHAAVAADSKVCSDIGRAILQQQGSPVDATIAALVCTSVVNPQSMGLGGGVIFTIYNVTTGKVE 105

  Fly   352 AIDAREVAPYEATEDMFAQ--QPENSDKGPLSIAVPGEVMGYHVAHQKFGQLPWAELVAPSLELC 414
            .|:|||..|......:..|  |......|...|.||||:.||..||::.|:||||:|..|::.|.
Human   106 VINARETVPASHAPSLLDQCAQALPLGTGAQWIGVPGELRGYAEAHRRHGRLPWAQLFQPTIALL 170

  Fly   415 EKGYHVSQHMERAL--DIALPYIKEHEQYQIYLNAETGKPHVAGTVVKPPKN------LCKTYKL 471
            ..|:.|:..:.|.|  .|..|.::.....|::.|         ||....|::      |..|.:.
Human   171 RGGHVVAPVLSRFLHNSILRPSLQASTLRQLFFN---------GTEPLRPQDPLPWPALATTLET 226

  Fly   472 LAENGPMDMYNGTIAKLLAEDLQDMGSIILADDLESYEADVINSITMDLGDDTLYVVPPVSSGSV 536
            :|..|....|.|.:.::|.||:...||.:...||..::.:|::::.:.|||.|||..||.:.|::
Human   227 VATEGVEVFYTGRLGQMLVEDIAKEGSQLTLQDLAKFQPEVVDALEVPLGDYTLYSPPPPAGGAI 291

  Fly   537 VAHVLAILQGYNFTAQDLSTEELKARTIHRFAEAMKFAFAQRPELGDMHFIDARELVSR-LNSPD 600
            ::.:|.:|:|:||:.:.::..|.:....|...|.:|||..||..|||.......:..|| |....
Human   292 LSFILNVLRGFNFSTESMARPEGRVNVYHHLVETLKFAKGQRWRLGDPRSHPKLQNASRDLLGET 356

  Fly   601 FGDQNRAKIND------SHV-LPDAQAYGANFAAIEDLDGTSNLVVLAPNGDAVSVTSSINSYFG 658
            .....|.:|:.      ||. |.:|..:|.         |||::.||..:|.||:.||:||:.||
Human   357 LAQLIRQQIDGRGDHQLSHYSLAEAWGHGT---------GTSHVSVLGEDGSAVAATSTINTPFG 412

  Fly   659 SGLIGPRTGIVLNNGMNDFAVK----NNIFALPQSQSNKIEAHK---------------RAMSSQ 704
            :.:..|||||:|||.:.|...:    :.....|.:..:.:...:               |:.||.
Human   413 AMVYSPRTGIILNNELLDLCERCPRGSGTTPSPDAVCSAVSGDRVGGAPGRCWPPVPGERSPSSM 477

  Fly   705 SPILLADKDGNMKMVIGAAGGSKIIPAVVEVAANVLWFGKDLRQAVDAPRFYHQLMPDVLEYEED 769
            .|.:|.:|....|:|||.|||..||.||.:...:.||.|.|||.|:.|| ..|......:|||.:
Human   478 VPSILINKAQGSKLVIGGAGGELIISAVAQAIMSKLWLGFDLRAAIAAP-ILHVNSKGCVEYEPN 541

  Fly   770 GFTES--------LLQ------LLTKRGHKLKSI-SVKTG---------------SVVTAISRNA 804
             |::.        |:.      :|..:..||.:: .|:.|               :||.|:|:..
Human   542 -FSQKQDLAALPRLVSNSWPQVILLPQPPKLLALQEVQRGLQDRGQNQTQRPFFLNVVQAVSQEG 605

  Fly   805 TAIYANADYRKRGGVAGF 822
            ..:||.:|.||.|..||:
Human   606 ACVYAVSDLRKSGEAAGY 623

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4829	NP_728030.2	G_glu_transpept	306..817	CDD:279371	177/577 (31%)
GGT5	XP_011528435.1	G_glu_transpept	60..618	CDD:279371	177/577 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146288
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0405
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1419292at2759
OrthoFinder	1	1.000	-	-		FOG0000229
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11686
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X210
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	8	7.810