DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ppk28 and asic1a

DIOPT Version :9

Sequence 1:	NP_573169.2	Gene:	ppk28 / 32671	FlyBaseID:	FBgn0030795	Length:	606	Species:	Drosophila melanogaster
Sequence 2:	XP_021333995.1	Gene:	asic1a / 791696	ZFINID:	ZDB-GENE-040513-2	Length:	614	Species:	Danio rerio

Alignment Length:	559	Identity:	129/559 - (23%)
Similarity:	200/559 - (35%)	Gaps:	185/559 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 YLKNSTLHGLKYI-AEESITIP---ERIFF--GLAFVLVVILS--VFFISNVYVKWSASPIIIST 99
            :...|||||:.:| :.|.||..   ..:||  .|.|::.|.:.  .|::...:|          |
Zfish   139 FAHTSTLHGISHIFSYEKITAKCCLWVVFFLSSLTFLMYVCIDRIQFYLEYPHV----------T 193

  Fly   100 SAKQKLTSNMPFPAITICNLNQALLSKVDR-------------------------------IGRT 133
            ...:..|..|.|||:||||||....|::.|                               :.::
Zfish   194 KLDEITTPVMVFPAVTICNLNSIRFSRITRNDLYHAGELLALLNSRHEVREAHLVEESVMEVLKS 258

  Fly   134 STNFSLLMGLCDQGGDTTISYIGTWKYFKAILVDVAQPCEKMLLYCSF-GS--REEDCSWLFTSI 195
            .|:|.....          .:...|:::.....|:    :.|||.|.| ||  |.||.|.:||..
Zfish   259 KTDFRSFKP----------RHFNMWEFYNRTGHDI----KDMLLSCQFRGSPCRPEDFSVVFTRY 309

  Fly   196 LTDDGLCCNFNALHPSYLIRNYSDDVRLETAHPNTRYELIDWTPEKGYARNLPEFYFPRTSGGTG 260
                |.|..||                               :.|.|     |    ||.|...|
Zfish   310 ----GKCYTFN-------------------------------SGETG-----P----PRVSVKGG 330

  Fly   261 IRMGLTVVLNASIAEYYCT------KSMSVGFKVLVHNPAELPKVSNYGFVVTAG-------REA 312
            :..||.::|:....||...      .|...|.||.:|:..|.|.:...||.|..|       :|.
Zfish   331 MGNGLEIMLDIQQDEYLPVWGESDESSFEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVSCQEQ 395

  Fly   313 RIPIEPVYEDALP----TIRSIKKSVRRCLFSDENDLAYYRTYSRKNCELECEAKLLLRECSCVL 373
            |:    ||   ||    :.:|...|      ||     |:|.||...|..:||.:.|:..|:|.:
Zfish   396 RL----VY---LPAPWGSCKSTPPS------SD-----YFRAYSISACRTDCETRYLVENCNCRM 442

  Fly   374 YYLPRIDPLARVCGPNDNQCTDRVQTE---------IESSLTNLSCENCWPGCFELTYRATLSTA 429
            .::|...|          .||..:..|         :|:.....|||.   .|....|...||..
Zfish   443 VHMPGDAP----------YCTPVLYKECAHPALDFLVETDSDYCSCET---PCNITRYSKELSFV 494

  Fly   430 SIVSD-------PRFQAGENLPEYIFHGPYSNASEISILHFYYMTNIFRSTTKSEMFGFTEFLSN 487
            .|.|.       .::...|   :||       ...:.:|..::....:.:..:.:.:.....|.:
Zfish   495 KIPSKASVKYLAKKYSKSE---KYI-------TENVMVLDVFFEALNYETIEQRKAYEVAGLLGD 549

  Fly   488 TGGLLGLFMGFSIFSVIEIFFYI-TVRPYCASRTLRQRH 525
            .||.:|||:|.||.:::|:|.|: .|..|...|...::|
Zfish   550 IGGQMGLFIGASILTILELFDYLYEVMKYRLCRCSNKKH 588

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk28	NP_573169.2	ASC	43..509	CDD:279230	124/540 (23%)
asic1a	XP_021333995.1	ASC	136..582	CDD:322155	127/551 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586605
Domainoid	1	1.000	101	1.000	Domainoid score	I6864
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	102	1.000	Inparanoid score	I4956
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm24766
orthoMCL	1	0.900	-	-		OOG6_100105
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3633
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.930