DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ppk28 and Asic4

DIOPT Version :9

Sequence 1:	NP_573169.2	Gene:	ppk28 / 32671	FlyBaseID:	FBgn0030795	Length:	606	Species:	Drosophila melanogaster
Sequence 2:	NP_071570.2	Gene:	Asic4 / 63882	RGDID:	621068	Length:	539	Species:	Rattus norvegicus

Alignment Length:	580	Identity:	137/580 - (23%)
Similarity:	219/580 - (37%)	Gaps:	152/580 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 KDSESDDDENTI--CSRAAIKRSVVYYLKNSTLHGLKYIAEESITIPERIFFGLAFVLVVILSVF 81
            |:.|:.|:::.:  ....|..|.:..:...||||||............|..:.||  |:..|:.|
  Rat    19 KEKEAGDEQSLLGAAQGPAAPRDLATFASTSTLHGLGRACGPGPHGLRRTLWVLA--LLTSLAAF 81

  Fly    82 FISNVYVKWSASPIIISTSAKQKLTSNMP--------FPAITICNLNQ---ALLSKVDRIGRTST 135
            .       :.|:.:......:..|.:..|        |||:|:||:|:   :.||..|..
  Rat    82 L-------YQAASLARGYLTRPHLVAMDPAAPAPVAGFPAVTLCNINRFRHSALSDADIF----- 134

  Fly   136 NFSLLMGL--CDQGGDTTISYIGTWKYFKAILVDV----AQPCEKMLLYCSFGSREEDCSWL-FT 193
            :.:.|.||  .|:.|......    :|.:..:||:    ......||..|:|....  ||.. |:
  Rat   135 HLANLTGLPPKDRDGHRAAGL----RYPEPDMVDILNRTGHQLADMLKSCNFSGHH--CSASNFS 193

  Fly   194 SILTDDGLCCNFNALHPSYLIRNYSDDVRLETAHPNTRYELIDWTPEKGYARNLPEFYFPRTSGG 258
            .:.|..|.|..|||                            |           |:...|..:||
  Rat   194 VVYTRYGKCYTFNA----------------------------D-----------PQSSLPSRAGG 219

  Fly   259 TGIRMGLTVVLNASIAEYY------CTKSMSVGFKVLVHNPAELPKVSNYGFVVTAGREARIPIE 317
            .|  .||.::|:....||.      ...|...|.:|.:|:..|.|.:...||.|:.|.:..:..:
  Rat   220 MG--SGLEIMLDIQQEEYLPIWRETNETSFEAGIRVQIHSQEEPPYIHQLGFGVSPGFQTFVSCQ 282

  Fly   318 PVYEDALP----TIRSIKKSVRRCLFSDENDLAYYRTYSRKNCELECEAKLLLRECSCVLYYLPR 378
            ......||    ..|:..| :|      |.:|..|..||...|.|.||.:.:|:.|.|.:.::|.
  Rat   283 EQRLTYLPQPWGNCRAESK-LR------EPELQGYSAYSVSACRLRCEKEAVLQRCHCRMVHMPG 340

  Fly   379 IDPLARVCGPNDN-QCTDRVQTEIESSLTNLSCENCWPGCF-----ELT-YRATLSTASIVS--D 434
            .:   .:|.||.. :|.|.       :|.:|...:..| ||     .|| |...:|...|.:  .
  Rat   341 NE---TICPPNIYIECADH-------TLDSLGGGSEGP-CFCPTPCNLTRYGKEISMVKIPNRGS 394

  Fly   435 PRFQAGENLPEYIFHGPYSNASEISILHFYYMTNIFRSTTKSE------MFGFTEFLSNTGGLLG 493
            .|:.|.:           .|.:|..|...:.:.::|.....||      .:|.:..|.:.||.:|
  Rat   395 ARYLARK-----------YNRNETYIRENFLVLDVFFEALTSEAMEQRAAYGLSALLGDLGGQMG 448

  Fly   494 LFMGFSIFSVIEIFFYITVRPYCASRTLRQRHKRRLEQLSWLTPIRMPVRRALRRNRGGL 553
            ||:|.||.:::||..||    |..|..       ||::: |..|     :..||.:.||:
  Rat   449 LFIGASILTLLEILDYI----YEVSWD-------RLKRV-WRRP-----KTPLRTSTGGI 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk28	NP_573169.2	ASC	43..509	CDD:279230	120/508 (24%)
Asic4	NP_071570.2	ASC	40..488	CDD:295594	131/554 (24%)
Asic4	NP_071570.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	501..531
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345670
Domainoid	1	1.000	111	1.000	Domainoid score	I6095
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8907
orthoMCL	1	0.900	-	-		OOG6_100105
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.750