DRSC/TRiP Functional Genomics Resources

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Protein Alignment ppk28 and Asic5

DIOPT Version :10

Sequence 1:NP_573169.2 Gene:ppk28 / 32671 FlyBaseID:FBgn0030795 Length:606 Species:Drosophila melanogaster
Sequence 2:NP_067345.1 Gene:Asic5 / 58170 MGIID:1929259 Length:495 Species:Mus musculus


Alignment Length:515 Identity:122/515 - (23%)
Similarity:194/515 - (37%) Gaps:125/515 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    43 YLKNSTLHGLKYIAEESITIPERIFFGLAFVL-VVILSVFFISNVYVKWSASPIIISTSAKQKLT 106
            :..:::.||:..||:....:.:.|:  ||.|| .|.|.|:.|.:..|.:...|  .:||.:.:..
Mouse    41 FAMSTSFHGIHNIAQNQNKVRKVIW--LAVVLGSVSLLVWQIYSRLVNYFTWP--TTTSIEVQYV 101

  Fly   107 SNMPFPAITICNLNQ----------------ALLSKVDRIGRTSTNFSLLMGLCDQGGDTTISYI 155
            ..:.|||:|:||||:                .::|||.|:...|.|        :.|...|:.::
Mouse   102 EKIEFPAVTLCNLNRFQTEAVSRFGIIFFLWDIVSKVLRLQEISAN--------NTGSPETLDFV 158

  Fly   156 GTWKYFKAILVDVAQP-----CEKMLLYCSFGSREEDCSWL-FTSILTDDGLCCNFNALHPSYLI 214
            ...:.|.  :.:..:.     ....|::|.|..:  .||.. |..:.|:.|.|..||        
Mouse   159 TNHQNFS--ITEFVKNNGFYLNNDTLVHCEFFGK--TCSPKDFKHVFTEYGNCFTFN-------- 211

  Fly   215 RNYSDDVRLETAHPNTRYELIDWTPEKGYARNLPEFYFPRTSGGTGIRMGLTVVLNASIAEYYCT 279
                                        |..|:........||     .||.::|:....|:  |
Mouse   212 ----------------------------YGENIQNKNKVSVSG-----RGLKLLLDVHQEEF--T 241

  Fly   280 KSMSVGFK-----VLVHNPAELPKVSNYGFVVTAGREARIPIEPVYEDALPTIRSIKKSVRRCLF 339
            .:...||.     .::|:|.:.|:....|.....|..||:           |||.:|...:...:
Mouse   242 DNPVPGFADAGVIFVIHSPKKEPQFDGLGLSSPVGMHARV-----------TIRQLKTVHQEYPW 295

  Fly   340 SDEN---DLAYYRTYSRKNCELECEAKLLLRECSCVLYYLP----RIDPLARVCGPNDNQCTDRV 397
            .:.|   .|..:.|||...|..||:|:.:.|.|.|:.:.||    ..|.|...      .|...:
Mouse   296 GECNPNIKLRNFITYSTYGCLKECKARHIQRLCGCLPFLLPGNGVECDLLEYY------NCVSPI 354

  Fly   398 QTEIE-SSLTNLSCEN--CWPGCFELTYRATLSTASIVSD--PRFQAGE--NLPEYIFHGPYSNA 455
            ...|| ..|..:...|  |...|.|..|.||:|.::..|.  .||.|.:  ...|||    ..|.
Mouse   355 LDHIERKGLCTMGTHNSSCPVSCEETEYPATVSYSTFPSQRATRFLAKKLNQSQEYI----RENL 415

  Fly   456 SEISILHFYYMTNIFRSTTKSEMFGFTEFLSNTGGLLGLFMGFSIFSVIEIFFYITVRPY 515
            ..|.|   .|....::.|.:.:.....|.|::.||.||||.|.|:.::|||..|.....|
Mouse   416 VNIEI---NYSDLNYKITQQQKAVSVPELLADVGGQLGLFCGASLITIIEIIEYFFTNFY 472

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ppk28NP_573169.2 ASC 43..509 CDD:459966 120/507 (24%)
Asic5NP_067345.1 Binds the plasma membrane and stabilizes the channel in the closed state. /evidence=ECO:0000250|UniProtKB:Q9R0W5 1..30
ASC 41..466 CDD:459966 120/507 (24%)
GAS motif, ion selectivity filter. /evidence=ECO:0000250|UniProtKB:P78348 454..456 1/1 (100%)
Blue background indicates that the domain is not in the aligned region.

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