Protein Alignment ppk28 and ASIC4

DIOPT Version :10

• Sequence 1: NP_573169.2
• Gene: ppk28 / 32671
• FlyBaseID: FBgn0030795
• Length: 606
• Species: Drosophila melanogaster
• Sequence 2: XP_054198812.1
• Gene: ASIC4 / 55515
• HGNCID: 21263
• Length: 666
• Species: Homo sapiens
• Alignment Length: 583
• Identity: 137/583 - (23%)
• Similarity: 216/583 - (37%)
• Gaps: 158/583 - (27%)

  Fly    19 KDSESDDDENTICSRA--AIKRSVVYYLKNSTLHGLKYIAEESITIPERIFFGLAFVLVVILSVF 81
            |:.|:.|:::.:.:.|  |..|.:..:...||||||............|..:.||  |:..|:.|
Human   146 KEKEAGDEQSLLGAVAPGAAPRDLATFASTSTLHGLGRACGPGPHGLRRTLWALA--LLTSLAAF 208

  Fly    82 FISNVYVKWSASPIIISTSAKQKLTSNMP--------FPAITICNLNQ---ALLSKVDRIGRTST 135
            .       :.|:.:......:..|.:..|        |||:|:||:|:   :.||..|..
Human   209 L-------YQAAGLARGYLTRPHLVAMDPAAPAPVAGFPAVTLCNINRFRHSALSDADIF----- 261

  Fly   136 NFSLLMGL--CDQGGDTTISYIGTWKYFKAILVDV----AQPCEKMLLYCSFGSREEDCSWL-FT 193
            :.:.|.||  .|:.|......    :|.:..:||:    ......||..|:|....  ||.. |:
Human   262 HLANLTGLPPKDRDGHRAAGL----RYPEPDMVDILNRTGHQLADMLKSCNFSGHH--CSASNFS 320

  Fly   194 SILTDDGLCCNFNALHPSYLIRNYSDDVRLETAHPNTRYELIDWTPEKGYARNLPEFYFPRTSGG 258
            .:.|..|.|..|||                            |           |....|..:||
Human   321 VVYTRYGKCYTFNA----------------------------D-----------PRSSLPSRAGG 346

  Fly   259 TGIRMGLTVVLNASIAEYY------CTKSMSVGFKVLVHNPAELPKVSNYGFVVTAG-------R 310
            .|  .||.::|:....||.      ...|...|.:|.:|:..|.|.:...||.|:.|       :
Human   347 MG--SGLEIMLDIQQEEYLPIWRETNETSFEAGIRVQIHSQEEPPYIHQLGFGVSPGFQTFVSCQ 409

  Fly   311 EARIPIEPVYEDALPTIRSIKKSVRRCLFSDENDLAYYRTYSRKNCELECEAKLLLRECSCVLYY 375
            |.|:...|     .|......:|..|     |.:|..|..||...|.|.||.:.:|:.|.|.:.:
Human   410 EQRLTYLP-----QPWGNCRAESELR-----EPELQGYSAYSVSACRLRCEKEAVLQRCHCRMVH 464

  Fly   376 LPRIDPLARVCGPNDN-QCTDRVQTEIESSLTNLS------CENCWPGCFELTYRATLSTASIVS 433
            :|..:   .:|.||.. :|.|.       :|.:|.      | .|...|....|...:|...|.:
Human   465 MPGNE---TICPPNIYIECADH-------TLDSLGGGPEGPC-FCPTPCNLTRYGKEISMVRIPN 518

  Fly   434 --DPRFQAGENLPEYIFHGPYSNASEISILHFYYMTNIFRSTTKSE------MFGFTEFLSNTGG 490
              ..|:.|.:           .|.:|..|...:.:.::|.....||      .:|.:..|.:.||
Human   519 RGSARYLARK-----------YNRNETYIRENFLVLDVFFEALTSEAMEQRAAYGLSALLGDLGG 572

  Fly   491 LLGLFMGFSIFSVIEIFFYITVRPYCASRTLRQRHKRRLEQLSWLTPIRMPVRRALRRNRGGL 553
            .:|||:|.||.:::||..||    |..|..       ||::: |..|     :..||.:.||:
Human   573 QMGLFIGASILTLLEILDYI----YEVSWD-------RLKRV-WRRP-----KTPLRTSTGGI 618

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk28	NP_573169.2	ASC	43..509	CDD:459966	119/511 (23%)
ASIC4	XP_054198812.1	ENaC	167..615	CDD:273304	130/557 (23%)