Protein Alignment ppk28 and ASIC4

DIOPT Version :9

• Sequence 1: NP_573169.2
• Gene: ppk28 / 32671
• FlyBaseID: FBgn0030795
• Length: 606
• Species: Drosophila melanogaster
• Sequence 2: NP_061144.4
• Gene: ASIC4 / 55515
• HGNCID: 21263
• Length: 539
• Species: Homo sapiens
• Alignment Length: 611
• Identity: 142/611 - (23%)
• Similarity: 224/611 - (36%)
• Gaps: 173/611 - (28%)

  Fly    19 KDSESDDDENTICSRA--AIKRSVVYYLKNSTLHGLKYIAEESITIPERIFFGLAFVLVVILSVF 81
            |:.|:.|:::.:.:.|  |..|.:..:...||||||............|..:.||  |:..|:.|
Human    19 KEKEAGDEQSLLGAVAPGAAPRDLATFASTSTLHGLGRACGPGPHGLRRTLWALA--LLTSLAAF 81

  Fly    82 FISNVYVKWSASPIIISTSAKQKLTSNMP--------FPAITICNLNQ---ALLSKVDRIGRTST 135
            .       :.|:.:......:..|.:..|        |||:|:||:|:   :.||..|..
Human    82 L-------YQAAGLARGYLTRPHLVAMDPAAPAPVAGFPAVTLCNINRFRHSALSDADIF----- 134

  Fly   136 NFSLLMGL--CDQGGDTTISYIGTWKYFKAILVDV----AQPCEKMLLYCSFGSREEDCSWL-FT 193
            :.:.|.||  .|:.|......    :|.:..:||:    ......||..|:|....  ||.. |:
Human   135 HLANLTGLPPKDRDGHRAAGL----RYPEPDMVDILNRTGHQLADMLKSCNFSGHH--CSASNFS 193

  Fly   194 SILTDDGLCCNFNALHPSYLIRNYSDDVRLETAHPNTRYELIDWTPEKGYARNLPEFYFPRTSGG 258
            .:.|..|.|..|||                            |           |....|..:||
Human   194 VVYTRYGKCYTFNA----------------------------D-----------PRSSLPSRAGG 219

  Fly   259 TGIRMGLTVVLNASIAEYY------CTKSMSVGFKVLVHNPAELPKVSNYGFVVTAG-------R 310
            .|  .||.::|:....||.      ...|...|.:|.:|:..|.|.:...||.|:.|       :
Human   220 MG--SGLEIMLDIQQEEYLPIWRETNETSFEAGIRVQIHSQEEPPYIHQLGFGVSPGFQTFVSCQ 282

  Fly   311 EARIPIEPVYEDALPTIRSIKKSVRRCLFSDENDLAYYRTYSRKNCELECEAKLLLRECSCVLYY 375
            |.|:...|     .|......:|..|     |.:|..|..||...|.|.||.:.:|:.|.|.:.:
Human   283 EQRLTYLP-----QPWGNCRAESELR-----EPELQGYSAYSVSACRLRCEKEAVLQRCHCRMVH 337

  Fly   376 LPRIDPLARVCGPNDN-QCTDRVQTEIESSLTNLS------CENCWPGCFELTYRATLSTASIVS 433
            :|..:   .:|.||.. :|.|.       :|.:|.      | .|...|....|...:|...|.:
Human   338 MPGNE---TICPPNIYIECADH-------TLDSLGGGPEGPC-FCPTPCNLTRYGKEISMVRIPN 391

  Fly   434 --DPRFQAGENLPEYIFHGPYSNASEISILHFYYMTNIFRSTTKSE------MFGFTEFLSNTGG 490
              ..|:.|.:           .|.:|..|...:.:.::|.....||      .:|.:..|.:.||
Human   392 RGSARYLARK-----------YNRNETYIRENFLVLDVFFEALTSEAMEQRAAYGLSALLGDLGG 445

  Fly   491 LLGLFMGFSIFSVIEIFFYITVRPYCASRTLRQRHKRRLEQLSWLTPIRMPVRRALRRNRGG--- 552
            .:|||:|.||.:::||..||    |..|..       ||::: |..|     :..||.:.||
Human   446 QMGLFIGASILTLLEILDYI----YEVSWD-------RLKRV-WRRP-----KTPLRTSTGGIST 493

  Fly   553 -----LLRNPPPPAYSDLQKFRGKLD 573
                 |....|.|:       ||:::
Human   494 LGLQELKEQSPCPS-------RGRVE 512

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk28	NP_573169.2	ASC	43..509	CDD:279230	119/511 (23%)
ASIC4	NP_061144.4	ASC	40..488	CDD:413546	130/557 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152171
Domainoid	1	1.000	99	1.000	Domainoid score	I7068
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	101	1.000	Inparanoid score	I4987
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm40930
orthoMCL	1	0.900	-	-		OOG6_100105
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3633
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.830