Protein Alignment ppk28 and ASIC5

DIOPT Version :10

• Sequence 1: NP_573169.2
• Gene: ppk28 / 32671
• FlyBaseID: FBgn0030795
• Length: 606
• Species: Drosophila melanogaster
• Sequence 2: NP_059115.1
• Gene: ASIC5 / 51802
• HGNCID: 17537
• Length: 505
• Species: Homo sapiens
• Alignment Length: 279
• Identity: 53/279 - (18%)
• Similarity: 91/279 - (32%)
• Gaps: 74/279 - (26%)

  Fly   239 EAQKKAQQAQAQAQAQQQALSQKKAQEEAQKKAQQAQQAQAQAQTQAQKKAQEDAQKKAQQAQQ- 302
            ::..:|.:.|...||...|||  :........:..:..::..|:|.....:..|:...:..::|
Human    63 QSPAEADEFQKSLQAALAALS--RGSLTPSSSSSSSSPSRDTAETPCPLTSHVDSDSSSSHSRQE 125

  Fly   303 ---------AAAQKKT----EVPVQAQAQPAQS--------TVPQKSGAIAQAQPAQQ-----EI 341
                     |..:..|    ..|.|.:...|||        .:|:.|.::|.|....:     |.
Human   126 TPPTAVAPIATVESATAFPPATPPQRRRSSAQSYPPLLPFTGIPEPSESLAGAGSQGRGGRGYED 190

  Fly   342 HAATGP------------KWSRTPG-KNQIQGPQPEQPKQATAVAPPT---------GKTALRQT 384
            :..:||            ::::|.. :....||....|...|..|||.         |.|.....
Human   191 YRRSGPPPPPLALSTCVVRFAKTGALRGAALGPPVSLPAPLTEAAPPALPARPPPGPGPTPAPAK 255

  Fly   385 VQVQEQELA---------------VGGHQAMSP----IMARKPQIQ--AEQLAQKFVEKPE-EQK 427
            ...:.:|.|               .||..|.:|    ::.|:....  ||.|....:...| :..
Human   256 ASPEAEEAARCVHCRALFRRRADGRGGRCAEAPDPGRLLVRRLSCLWCAESLLYHCLSDAEGDFS 320

  Fly   428 DKQAVQKGQQLEGAKRWVA 446
            |..|.:.|.. ..|.||.|
Human   321 DPCACEPGHP-RPAARWAA 338

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk28	NP_573169.2	ASC	43..509	CDD:459966	53/279 (19%)
ASIC5	NP_059115.1	Binds the plasma membrane and stabilizes the channel in the closed state. /evidence=ECO:0000250|UniProtKB:Q9R0W5	1..30
		ASC	41..466	CDD:459966	53/279 (19%)
		GAS motif, ion selectivity filter. /evidence=ECO:0000250|UniProtKB:P78348	454..456