DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ppk28 and ASIC1

DIOPT Version :9

Sequence 1:	NP_573169.2	Gene:	ppk28 / 32671	FlyBaseID:	FBgn0030795	Length:	606	Species:	Drosophila melanogaster
Sequence 2:	NP_064423.2	Gene:	ASIC1 / 41	HGNCID:	100	Length:	574	Species:	Homo sapiens

Alignment Length:	571	Identity:	133/571 - (23%)
Similarity:	205/571 - (35%)	Gaps:	185/571 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 SVVYYLKNSTLHGLKYI-AEESITIPERIFFGLAFV--LVVILSV------FFISNVYVKWSASP 94
            |:..:..:||||||.:| :.|.::: :|..:.|.|:  |.|:|.|      ::....:|
Human    17 SIQAFASSSTLHGLAHIFSYERLSL-KRALWALCFLGSLAVLLCVCTERVQYYFHYHHV------ 74

  Fly    95 IIISTSAKQKLTSNMPFPAITICNLNQALLSKVDRIGRTSTNFSLLMGLCDQGGDTTISYIGTWK 159
                |...:...|.:.|||:|:||||:...|:|.:  ....:...|:.|.:...:...:.:...|
Human    75 ----TKLDEVAASQLTFPAVTLCNLNEFRFSQVSK--NDLYHAGELLALLNNRYEIPDTQMADEK 133

  Fly   160 YFKAILVDVA--------------------QPCEKMLLYCSFGSREEDCSWL-FTSILTDDGLCC 203
            ..: ||.|.|                    .....|||.|.|  |.|.||.. |..:.|..|.|.
Human   134 QLE-ILQDKANFRSFKPKPFNMREFYDRAGHDIRDMLLSCHF--RGEVCSAEDFKVVFTRYGKCY 195

  Fly   204 NFNALHPSYLIRNYSDDVRLETAHPNTRYELIDWTPEKGYARNLPEFYFPRTSGGTGIRMGLTVV 268
            .||:        ......||:|                             ..||||  .||.::
Human   196 TFNS--------GRDGRPRLKT-----------------------------MKGGTG--NGLEIM 221

  Fly   269 LNASIAEYYCT------KSMSVGFKVLVHNPAELPKVSNYGFVVTAG-------REARIPIEPVY 320
            |:....||...      .|...|.||.:|:..|.|.:...||.|..|       :|.|:    :|
Human   222 LDIQQDEYLPVWGETDETSFEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVACQEQRL----IY 282

  Fly   321 EDALPTIRSIKKSVRRCLFSDENDLAYYRTYSRKNCELECEAKLLLRECSCVLYYLPRIDPLARV 385
               ||......|:|     :.::||.::.:||...|.::||.:.|:..|:|.:.::|...|   .
Human   283 ---LPPPWGTCKAV-----TMDSDLDFFDSYSITACRIDCETRYLVENCNCRMVHMPGDAP---Y 336

  Fly   386 CGPND-NQCTD-----RVQTEIESSLTNLSCENCWPGCFELT-YRATLSTASIVS--DPRFQA-- 439
            |.|.. .:|.|     .|:.:.|..:..:.|        .|| |...||...|.|  ..::.|
Human   337 CTPEQYKECADPALDFLVEKDQEYCVCEMPC--------NLTRYGKELSMVKIPSKASAKYLAKK 393

  Fly   440 --------GEN---------------------------LPEYIF---------HG--PYSNASEI 458
                    |||                           |.|.:.         ||  ||...:..
Human   394 FNKSEQYIGENILVLDIFFEVLNYETIEQKKAYEIAGLLGELLMTPVPFSCHGHGVAPYHPKAGC 458

  Fly   459 SILHFYYMTNIFRSTTKSEMFGFTEFLSNTGGLLGLFMGFSIFSVIEIFFY 509
            |:|.       .........|.....|.:.||.:|||:|.||.:|:|:|.|
Human   459 SLLS-------HEGPPPQRPFPKPCCLGDIGGQMGLFIGASILTVLELFDY 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk28	NP_573169.2	ASC	43..509	CDD:279230	131/565 (23%)
ASIC1	NP_064423.2	ENaC	19..556	CDD:273304	132/569 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152129
Domainoid	1	1.000	99	1.000	Domainoid score	I7068
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	101	1.000	Inparanoid score	I4987
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm40930
orthoMCL	1	0.900	-	-		OOG6_100105
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3633
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.830