Protein Alignment ppk28 and asic4b

DIOPT Version :10

• Sequence 1: NP_573169.2
• Gene: ppk28 / 32671
• FlyBaseID: FBgn0030795
• Length: 606
• Species: Drosophila melanogaster
• Sequence 2: NP_999951.1
• Gene: asic4b / 407667
• ZFINID: ZDB-GENE-040513-6
• Length: 558
• Species: Danio rerio
• Alignment Length: 586
• Identity: 135/586 - (23%)
• Similarity: 216/586 - (36%)
• Gaps: 182/586 - (31%)

  Fly     4 LTESRRRQSGSSGCKKDSESDDDENTICSRAAIKRSVVYYLKNSTLHGLKYIAEESITIPERIFF 68
            |.|..|||       |:..:|               :..:..:|:||||    ..::...||:.|
Zfish    30 LDEGLRRQ-------KEGMAD---------------LASFASSSSLHGL----ARALGTSERLGF 68

  Fly    69 -----GLAFVLVVILSVFFISNVYVKWSASPII-------ISTSAKQKLTSNMPFPAITICNLNQ 121
                 |||  |:|.|.:|...   ..|||:..:       :....:::||    |||||:||:|:
Zfish    69 RQTLWGLA--LLVSLGLFLYQ---ATWSAATYLERPHLAALREETRRELT----FPAITLCNVNR 124

  Fly   122 ALLSKVDRIGRTSTNFSLLMGLCDQGGDTTISYIGT----------------WKYFKAILVDVAQ 170
                         ..||.|.       |..|.::..                .:|....::|:.|
Zfish   125 -------------FRFSALT-------DADIYHLANLTGLPPKSRKGHRPSELQYPPPNMLDIFQ 169

  Fly   171 ----PCEKMLLYCSFGSR---EEDCSWLFTSILTDDGLCCNFNALHPSYLIRNYSDDVRLETAHP 228
                ..|.||..|:|..:   .||    |:.:.|..|.|..||.        |.:...|:.
Zfish   170 RTGHQLEDMLKSCNFSGQNCSSED----FSVVYTRYGKCYTFNG--------NKTSPKRVR---- 218

  Fly   229 NTRYELIDWTPEKGYARNLPEFYFPRTSGGTGIRMGLTVVLNASIAEYY------CTKSMSVGFK 287
                                       .||||  .||.::|:....||.      ...::..|.:
Zfish   219 ---------------------------QGGTG--NGLEMMLDIQQDEYLPIWRETNETTLEAGIR 254

  Fly   288 VLVHNPAELPKVSNYGFVVTAGREARIPIEPVYEDALPTIRSIKKSVRRCLFSDENDLAYYRTYS 352
            |.:|:..|.|.:...||.|:.|.:..:..:......||      :....|..|.|..:..|.|||
Zfish   255 VQIHSQNEPPYIHQLGFGVSPGFQTFVSCQEQRLTYLP------QPWGNCRASSEPVIPGYDTYS 313

  Fly   353 RKNCELECEAKLLLRECSCVLYYLPRIDPLARVCGPNDNQCTDRVQTEIESSLTNLSCENCWPGC 417
            ...|.|.||:..:.|||:|.:.::|..   |.:|.|:..:|.|:....::.| |..||. |...|
Zfish   314 VSACRLHCESTQVQRECNCRMVHMPGD---ADICAPSKIKCVDKALASLQKS-TGDSCP-CETPC 373

  Fly   418 FELTYRATLSTASIVS-------DPRFQAGENLPEYIFHGPYSNASEISILHFYYMTNIFRSTTK 475
            ....|...||...|.|       ..::|..|   |||       .....||..::....:.:..:
Zfish   374 NLTRYGKELSMVKIPSRGSARYLSRKYQKSE---EYI-------RDNFLILDIFFEALNYETIEQ 428

  Fly   476 SEMFGFTEFLSNTGGLLGLFMGFSIFSVIEIFFYI----------TVRPYCASRTLRQRHKRRLE 530
            .:.:.....|.:.||.:|||:|.||.:::||..||          .::|   .::.:|.::|.|.
Zfish   429 KKAYDIAGLLGDIGGQMGLFIGASILTILEILDYIYEVAKNKIKQLLKP---KKSQKQTNQRNLI 490

  Fly   531 Q 531
            |
Zfish   491 Q 491

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk28	NP_573169.2	ASC	43..509	CDD:459966	121/513 (24%)
asic4b	NP_999951.1	ENaC	54..497	CDD:273304	126/540 (23%)
		GAS motif, ion selectivity filter. /evidence=ECO:0000250|UniProtKB:P78348	450..452		1/1 (100%)