Protein Alignment ppk28 and ASIC2

DIOPT Version :9

• Sequence 1: NP_573169.2
• Gene: ppk28 / 32671
• FlyBaseID: FBgn0030795
• Length: 606
• Species: Drosophila melanogaster
• Sequence 2: NP_899233.1
• Gene: ASIC2 / 40
• HGNCID: 99
• Length: 563
• Species: Homo sapiens
• Alignment Length: 542
• Identity: 114/542 - (21%)
• Similarity: 185/542 - (34%)
• Gaps: 172/542 - (31%)

  Fly    44 LKNSTLHGLKYIAEESI----TIPERIFFGLAFVLVVILSVFFISNVYVKWSASPIIISTSAKQK 104
            |..:.||||:::.....    :...|..:.|||.....|.:.:.||..:.|.:.|  ..|...::
Human    61 LSRAKLHGLRHMCAGRTAAGGSFQRRALWVLAFCTSFGLLLSWSSNRLLYWLSFP--SHTRVHRE 123

  Fly   105 LTSNMPFPAITICNLNQALLSKVDRIGRTSTNFSLLMGLCDQGGDTTISYIGTW----------- 158
            .:..:||||:|:||.|.....::.:                  ||  :.|.|.|
Human   124 WSRQLPFPAVTVCNNNPLRFPRLSK------------------GD--LYYAGHWLGLLLPNRTAR 168

  Fly   159 -----------------------------KYFKAI---LVD-VAQPCEKMLLYCSFGSREEDCS- 189
                                         ::|:.|   .:| :....|.|||.|.:  |.|.|.
Human   169 PLVSELLRGDEPRRQWFRKLADFRLFLPPRHFEGISAAFMDRLGHQLEDMLLSCKY--RGELCGP 231

  Fly   190 WLFTSILTDDGLCCNFNALHPSYLIRNYSDDVRLETAHPNTRYELIDWTPEKGYARNLPEFYFPR 254
            ..|:|:.|..|.|         |:..:..|...|.|.
Human   232 HNFSSVFTKYGKC---------YMFNSGEDGKPLLTT---------------------------- 259

  Fly   255 TSGGTGIRMGLTVVLNASIAEYYC------TKSMSVGFKVLVHNPAELPKVSNYGFVVTAG---- 309
            ..||||  .||.::|:....||..      ..:...|.||.:|:.:|.|.:...||.|..|
Human   260 VKGGTG--NGLEIMLDIQQDEYLPIWGETEETTFEAGVKVQIHSQSEPPFIQELGFGVAPGFQTF 322

  Fly   310 ---REARIPIEPVYEDALPTIRSIKKSVRRCLFSDENDLAYYRTYSRKNCELECEAKLLLRECSC 371
               :|.|:...|      |.....:        |.|..|.::..||...|.::||.:.::..|:|
Human   323 VATQEQRLTYLP------PPWGECR--------SSEMGLDFFPVYSITACRIDCETRYIVENCNC 373

  Fly   372 VLYYLPRIDPLARVCGPNDNQCTDRVQTEIESSLTNLSCEN------CWPGCFELTYRATLSTAS 430
            .:.::|...|.          ||.....|.......|..|.      |...|....|...||...
Human   374 RMVHMPGDAPF----------CTPEQHKECAEPALGLLAEKDSNYCLCRTPCNLTRYNKELSMVK 428

  Fly   431 IVS-------DPRFQAGENLPEYIFHGPYSNASEISILHFYYMTNIFRSTTKSEMFGFTEFLSNT 488
            |.|       :.:|...|   :||       :..|.:|..::....:.:..:.:.:.....|.:.
Human   429 IPSKTSAKYLEKKFNKSE---KYI-------SENILVLDIFFEALNYETIEQKKAYEVAALLGDI 483

  Fly   489 GGLLGLFMGFSIFSVIEIFFYI 510
            ||.:|||:|.||.:::|:|.||
Human   484 GGQMGLFIGASILTILELFDYI 505

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk28	NP_573169.2	ASC	43..509	CDD:279230	112/539 (21%)
ASIC2	NP_899233.1	ENaC	64..547	CDD:273304	113/539 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152149
Domainoid	1	1.000	99	1.000	Domainoid score	I7068
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	101	1.000	Inparanoid score	I4987
Isobase	1	0.950	-	0	Normalized mean entropy	S7217
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm40930
orthoMCL	1	0.900	-	-		OOG6_100105
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	12	11.750