DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ppk28 and egas-4

DIOPT Version :9

Sequence 1:	NP_573169.2	Gene:	ppk28 / 32671	FlyBaseID:	FBgn0030795	Length:	606	Species:	Drosophila melanogaster
Sequence 2:	NP_501207.2	Gene:	egas-4 / 3564809	WormBaseID:	WBGene00018906	Length:	883	Species:	Caenorhabditis elegans

Alignment Length:	474	Identity:	101/474 - (21%)
Similarity:	155/474 - (32%)	Gaps:	164/474 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   144 CDQGGDTTISYIG-----------TWKYFKAILVDVAQPCEKMLL-----------------YC- 179
            |:.||:.. ..||           .|..|.. .:||.:..|...|                 ||
Worm   450 CENGGECE-DIIGPPNSYNCTCTPQWTGFNC-TIDVDECVEDTTLCKTKDPDATCVNTNGSYYCV 512

  Fly   180 ----SFGSREEDCSWLFTSILTDDGLCCNFNALHPS---------------------YLIRNYSD 219
                .||.     |.||..|:... |...:..|.|.                     :||..||.
Worm   513 CSPNMFGK-----SCLFNKIIYQI-LNATYGDLGPDKLDEMAQELTNDPTLVRDIVPFLIGGYSL 571

  Fly   220 DVRLETAHPNTRYELIDWTPEKGYARNLPEF--------------------------YFPRTSGG 258
            :||  |:...|..::..|.   .|.:.|.:.                          |..|:||.
Worm   572 EVR--TSLSWTAADMFLWV---AYEQQLIDLNSNFVQWNDKVLGNCFTFNHMNSSFKYEARSSGY 631

  Fly   259 TGIRMGLTVVLNASIAEYYCTKSMSVGFKVLVHNPAELPKVSNYGFVV-TAGREARIPIEPVYED 322
            .|   ||.:.:|....||                   ||.....|.:| |:.:|..:..|.|..:
Worm   632 PG---GLEMQMNVKQDEY-------------------LPWTETAGVMVFTSTKEEAVTSESVRIN 674

  Fly   323 ALPTIRSIKKSVRR------------CLFSDENDLAYY--RTYSRKNCELECEAKLLLRECSCVL 373
            ..|...| :.::.|            |:.|.....:||  ..|:...|...|...::..:|.|
Worm   675 TAPHFES-RIAINRVDYYRLGGRYGVCINSVSEVKSYYYDGDYTTDGCLRSCYQDVVNGDCGC-- 736

  Fly   374 YYLPRIDPLARVCGPNDN-QCTDRVQTEIESSLTNLSCENCWPGC-FELTYRATLSTASIVSDPR 436
                 :||  |...|||. .|:...:|.|:..:.:....:.||.| ..|....|:.|:.:...|.
Worm   737 -----MDP--RYPMPNDGISCSISQKTCIDELVDSRGDPSTWPECTCPLPCSQTVYTSKLSRLPY 794

  Fly   437 FQAGENLPEYIFHGPYSNAS------------EISILHFYYMTNIFRSTTKSEMFGFTEFLSNTG 489
            .....:..|     .|:|.:            .||:....||  |:..|...::   |:|:|..|
Worm   795 VNKIVDCEE-----AYTNKTACYETFLDSVILRISLPKLDYM--IYSETPAMDL---TKFMSYLG 849

  Fly   490 GLLGLFMGFSIFSVIEIFF 508
            |:|.:.:|.||.|.:|:||
Worm   850 GILSILIGVSIVSFVELFF 868

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk28	NP_573169.2	ASC	43..509	CDD:279230	101/474 (21%)
egas-4	NP_501207.2	EGF	101..131	CDD:278437
		EGF_CA	482..522	CDD:238011	8/44 (18%)
		ASC	<610..869	CDD:279230	68/301 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820