DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ppk28 and Asic2

DIOPT Version :9

Sequence 1:	NP_573169.2	Gene:	ppk28 / 32671	FlyBaseID:	FBgn0030795	Length:	606	Species:	Drosophila melanogaster
Sequence 2:	NP_037024.2	Gene:	Asic2 / 25364	RGDID:	2017	Length:	563	Species:	Rattus norvegicus

Alignment Length:	542	Identity:	113/542 - (20%)
Similarity:	186/542 - (34%)	Gaps:	172/542 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 LKNSTLHGLKYIAEESI----TIPERIFFGLAFVLVVILSVFFISNVYVKWSASPIIISTSAKQK 104
            |..:.||||:::.....    :...|..:.|||...:.|.:.:.||..:.|.:.|  ..|...::
  Rat    61 LSRTKLHGLRHMCAGRTAAGGSFQRRALWVLAFCTSLGLLLSWSSNRLLYWLSFP--SHTRVHRE 123

  Fly   105 LTSNMPFPAITICNLNQALLSKVDRIGRTSTNFSLLMGLCDQGGDTTISYIGTW----------- 158
            .:..:||||:|:||.|.....::.:                  ||  :.|.|.|
  Rat   124 WSRQLPFPAVTVCNNNPLRFPRLSK------------------GD--LYYAGHWLGLLLPNRTAR 168

  Fly   159 -----------------------------KYFKAI---LVD-VAQPCEKMLLYCSFGSREEDCS- 189
                                         ::|:.|   .:| :....|.|||.|.:  |.|.|.
  Rat   169 PLVSELLRGDEPRRQWFRKLADFRLFLPPRHFEGISAAFMDRLGHQLEDMLLSCKY--RGELCGP 231

  Fly   190 WLFTSILTDDGLCCNFNALHPSYLIRNYSDDVRLETAHPNTRYELIDWTPEKGYARNLPEFYFPR 254
            ..|:|:.|..|.|         |:..:..|...|.|.
  Rat   232 HNFSSVFTKYGKC---------YMFNSGEDGKPLLTT---------------------------- 259

  Fly   255 TSGGTGIRMGLTVVLNASIAEYYC------TKSMSVGFKVLVHNPAELPKVSNYGFVVTAG---- 309
            ..||||  .||.::|:....||..      ..:...|.||.:|:.:|.|.:...||.|..|
  Rat   260 VKGGTG--NGLEIMLDIQQDEYLPIWGETEETTFEAGVKVQIHSQSEPPFIQELGFGVAPGFQTF 322

  Fly   310 ---REARIPIEPVYEDALPTIRSIKKSVRRCLFSDENDLAYYRTYSRKNCELECEAKLLLRECSC 371
               :|.|:...|      |.....:        |.|..|.::..||...|.::||.:.::..|:|
  Rat   323 VATQEQRLTYLP------PPWGECR--------SSEMGLDFFPVYSITACRIDCETRYIVENCNC 373

  Fly   372 VLYYLPRIDPLARVCGPNDNQCTDRVQTEIESSLTNLSCEN------CWPGCFELTYRATLSTAS 430
            .:.::|...|.          ||.....|.......|..|.      |...|....|...||...
  Rat   374 RMVHMPGDAPF----------CTPEQHKECAEPALGLLAEKDSNYCLCRTPCNLTRYNKELSMVK 428

  Fly   431 IVS-------DPRFQAGENLPEYIFHGPYSNASEISILHFYYMTNIFRSTTKSEMFGFTEFLSNT 488
            |.|       :.:|...|   :||       :..|.:|..::....:.:..:.:.:.....|.:.
  Rat   429 IPSKTSAKYLEKKFNKSE---KYI-------SENILVLDIFFEALNYETIEQKKAYEVAALLGDI 483

  Fly   489 GGLLGLFMGFSIFSVIEIFFYI 510
            ||.:|||:|.|:.:::|:|.||
  Rat   484 GGQMGLFIGASLLTILELFDYI 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk28	NP_573169.2	ASC	43..509	CDD:279230	111/539 (21%)
Asic2	NP_037024.2	ENaC	64..557	CDD:273304	112/539 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345652
Domainoid	1	1.000	111	1.000	Domainoid score	I6095
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8907
orthoMCL	1	0.900	-	-		OOG6_100105
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.850