DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ppk28 and Scnn1b

DIOPT Version :9

Sequence 1:	NP_573169.2	Gene:	ppk28 / 32671	FlyBaseID:	FBgn0030795	Length:	606	Species:	Drosophila melanogaster
Sequence 2:	NP_036780.1	Gene:	Scnn1b / 24767	RGDID:	3640	Length:	638	Species:	Rattus norvegicus

Alignment Length:	644	Identity:	138/644 - (21%)
Similarity:	224/644 - (34%)	Gaps:	202/644 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 KRSVVYYLKNSTLHGLKYIAEESITIPER--IFFGLAFVLVVIL----SVFFISNVYVKWSASPI 95
            |..:|:|..|:..||.|.|..|.   |::  ::|.|..:...::    .||.  ..|:.|..|
  Rat    23 KELLVWYCNNTNTHGPKRIICEG---PKKKAMWFLLTLLFACLVCWQWGVFI--QTYLSWEVS-- 80

  Fly    96 IISTSAKQKLTSNMPFPAITICN------------------LNQALLSKV-----DRIGRTST-N 136
             :|.|...|   .|.|||:|:||                  |.:|:|.|:     .....||| |
  Rat    81 -VSLSMGFK---TMNFPAVTVCNSSPFQYSKVKHLLKDLYKLMEAVLDKILAPKSSHTNTTSTLN 141

  Fly   137 FSLLMGLCDQGGDTTISYIGTWKYFKAILVDVAQPCEKMLLYCSFGS-------------REEDC 188
            |::                  |.:...:|:|...|...::|.. ||.             ..:.|
  Rat   142 FTI------------------WNHTPLVLIDERNPDHPVVLNL-FGDSHNSSNPAPGSTCNAQGC 187

  Fly   189 SWLFTSILTDDGLCCNFNALHPSYLIRNYSDDVRLETAHPNTRYELIDW------------TPE- 240
            . :...:.:.:|..|.|         ||::...:..|          :|            .|:
  Rat   188 K-VAMRLCSANGTVCTF---------RNFTSATQAVT----------EWYILQATNIFSQVLPQD 232

  Fly   241 ---KGYA-----------------RNLPEFYFP----------------RTSGGTGIRMGLTVVL 269
               .|||                 ||....::|                ..|...|...||.::|
  Rat   233 LVGMGYAPDRIILACLFGTEPCSHRNFTPIFYPDYGNCYIFNWGMTEKALPSANPGTEFGLKLIL 297

  Fly   270 NASIAEYYCTKSMSVGFKVLVHNPAELPKVSNYGFVVTAGREARIPI---------EPVYEDALP 325
            :....:|....:.:.|.::::|.....|.:...|....||.|..|.:         || |...
  Rat   298 DIGQEDYVPFLASTAGARLMLHEQRTYPFIREEGIYAMAGTETSIGVLLDKLQGKGEP-YSPC-- 359

  Fly   326 TIRSIKKSVRRCLFSDENDLAYYRTYSRKNCELECEAKLLLRECSC--VLYYLPRIDPLARVCG- 387
            |:.....:::. |:||     |..|||.:.|...|....::..|||  .||.||..:   :.|.
  Rat   360 TMNGSDVAIQN-LYSD-----YNTTYSIQACLHSCFQDHMIHNCSCGHYLYPLPAGE---KYCNN 415

  Fly   388 ---PNDNQCTDRVQTEIESSLTNLSCENCWPGCFELTYRATLSTASIVSDPRFQAGENLPEYIFH 449
               |:...|...:|..:....|.||.  |...|.:..|:.|:|.|...|    :|.|:...::..
  Rat   416 RDFPDWAYCYLSLQMSVVQRETCLSM--CKESCNDTQYKMTISMADWPS----EASEDWILHVLS 474

  Fly   450 GPYSNASEISI-------LHFYYMTNIFRSTTKSEMFGFTEFLSNTGGLLGLFMGFSIFSVIEIF 507
            .....:|.|::       |:.|:....:|:..:|........|||.||..|.:||.|:..:|| |
  Rat   475 QERDQSSNITLSRKGIVKLNIYFQEFNYRTIEESPANNIVWLLSNLGGQFGFWMGGSVLCLIE-F 538

  Fly   508 FYITVRPYCASRTLRQRHKRRLEQLSWLTPIRMPVR-RALRRNRGGLLRNPPPPAYSDL 565
            ..|.:                  ...|:|.|::... :.|||.|.......|||..::|
  Rat   539 GEIII------------------DFIWITVIKLVASCKGLRRRRPQRPYTGPPPTVAEL 579

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk28	NP_573169.2	ASC	43..509	CDD:279230	124/579 (21%)
Scnn1b	NP_036780.1	ENaC	21..621	CDD:273304	138/644 (21%)
		deg-1	29..538	CDD:273309	123/577 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	598..620
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345642
Domainoid	1	1.000	111	1.000	Domainoid score	I6095
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	111	1.000	Inparanoid score	I4773
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8907
orthoMCL	1	0.900	-	-		OOG6_100105
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.700