Protein Alignment ppk28 and Asic3

DIOPT Version :10

• Sequence 1: NP_573169.2
• Gene: ppk28 / 32671
• FlyBaseID: FBgn0030795
• Length: 606
• Species: Drosophila melanogaster
• Sequence 2: XP_006535700.1
• Gene: Asic3 / 171209
• MGIID: 2159339
• Length: 563
• Species: Mus musculus
• Alignment Length: 634
• Identity: 134/634 - (21%)
• Similarity: 213/634 - (33%)
• Gaps: 210/634 - (33%)

  Fly     4 LTESRRRQSGSSGCKKDSESDDDENTICSRAAIKRSVVYYLKNSTLHGLKYI-AEESITI----- 62
            |.|::|||:          ||               :..:..:.|:|||.:| ....:|:
Mouse     7 LEEAQRRQA----------SD---------------IRVFANSCTMHGLGHIFGPGGLTLRRGLW 46

  Fly    63 PERIFFGL-AFVLVVILSVFFISNVYVKWSASPIIISTSAKQKLTSNMPFPAITICNLNQALLSK 126
            ...:...| ||:..|...|.:....:.|         |:..::.:..:.|||:|:||:|..
Mouse    47 ATAVLLSLAAFLYQVAERVRYYGEFHHK---------TTLDERESHQLTFPAVTLCNINPL---- 98

  Fly   127 VDRIGRTSTN-----FSLLMGLCDQGGDTTISYIGTWKYFKAI-------------LVDVAQ--- 170
              |..|.:.|     .:.|:|| |......        |.:|:             ..|:||
Mouse    99 --RRSRLTPNDLHWAGTALLGL-DPAEHAA--------YLRALGQPPAPPGFMPSPTFDMAQLYA 152

  Fly   171 ----PCEKMLLYCSFGSREEDCS-WLFTSILTDDGLCCNFNALHPSYLIRNYSDDVRLETAHPNT 230
                ..|.|||.|.:  |.:.|. ..||.|.|..|.|..||         :.:....|.|
Mouse   153 RAGHSLEDMLLDCRY--RGQPCGPENFTVIFTRMGQCYTFN---------SGAQGAELLT----- 201

  Fly   231 RYELIDWTPEKGYARNLPEFYFPRTSGGTGIRMGLTVVLNASIAEYY-CTKSM-----SVGFKVL 289
                   ||:                ||.|  .||.::|:....||. ..|.|     .||.:|.
Mouse   202 -------TPK----------------GGAG--NGLEIMLDVQQEEYLPIWKDMEETPFEVGIRVQ 241

  Fly   290 VHNPAELPKVSNYGFVVTAGREARIPIEPVYEDALP------TIRSIKKSVRRCLFSDE-----N 343
            :|...|.|.:...||....|.:..:..:......||      ...|:...     |..|     .
Mouse   242 IHGQEEPPAIDQLGFGAAPGHQTFVSCQQQQLSFLPPPWGDCNTASVDPD-----FDPEPSDPLG 301

  Fly   344 DLAYYRTYSRKNCELECEAKLLLRECSCVLYYLPRIDPLARVCGPND-NQCTD------------ 395
            ..:....||...|.|.||::.:.|:|.|.:.::|...|   ||.|.. ..|..
Mouse   302 SPSSSPPYSLIGCRLACESRYVARKCGCRMMHMPGNSP---VCSPQQYKDCASPALGKAHLFSLP 363

  Fly   396 -RVQTEI-----------------ESSLTNLSCENCWPGCFELTYRATLSTASIVS--DPRFQAG 440
             .:.::|                 ::.|...:|. |...|....|...||...|.|  ..|:.|.
Mouse   364 VPIHSDIDHNPLGQVLLFLALRPADAMLRKDTCV-CPNPCATTRYAKELSMVRIPSRASARYLAR 427

  Fly   441 E-NLPE-YIFHGPYSNASEISILHFYYMTNIFRSTTKSEMFGFTEFLSNTGGLLGLFMGFSIFSV 503
            : |..| ||       ...:.:|..::....:.:..:...:..:|.|.:.||.:|||:|.|:.::
Mouse   428 KYNRSETYI-------TENVLVLDIFFEALNYEAVEQKAAYEVSELLGDIGGQMGLFIGASLLTI 485

  Fly   504 IEIFFYI------TVRPYCASRTLRQR-------------HKRRLEQLS 533
            :||..|:      .|..|..:|...||             |:..:..||
Mouse   486 LEILDYLCEVFQDRVLGYFWNRRSSQRRSGNTLLQEELNGHRTHVPHLS 534

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk28	NP_573169.2	ASC	43..509	CDD:459966	118/550 (21%)
Asic3	XP_006535700.1	ENaC	21..546	CDD:273304	127/595 (21%)