Protein Alignment CG4768 and HAPSTR1

DIOPT Version :10

• Sequence 1: NP_573164.2
• Gene: CG4768 / 32666
• FlyBaseID: FBgn0030790
• Length: 269
• Species: Drosophila melanogaster
• Sequence 2: NP_054836.2
• Gene: HAPSTR1 / 29035
• HGNCID: 30103
• Length: 275
• Species: Homo sapiens
• Alignment Length: 281
• Identity: 89/281 - (31%)
• Similarity: 125/281 - (44%)
• Gaps: 61/281 - (21%)

  Fly     1 MQQQPESG-------GEESWL---EEQCHREIHGQHDEY-------EREFVRQRDNNLGTVWGAF 48
            |:::.|.|       |.|.|.   |.||..|  .:.||.       |.....|.::....:|..|
Human     1 MEERKEEGEAEIQEHGPEHWFSKWERQCLAE--AEQDEQLPPELQEEAAAAAQPEHKQQKLWHLF 63

  Fly    49 QDSATAVAQLYRERSSNTFSSDTG-ALWLPFQTAAGTVTTLYKESCDGLKRTSDAAIQCGYQRRT 112
            |:|||||||||::|    .....| :||:|||.||..||.|||||.|..:|:.|..||.|||||.
Human    64 QNSATAVAQLYKDR----VCQQPGLSLWVPFQNAATAVTNLYKESVDTHQRSFDIGIQIGYQRRN 124

  Fly   113 RELADWARSKKRRMIRREDLLAYLAGKPLPPCNSN--PHANRRSPKPEHHHQSGSG--------G 167
            :::..|.: |:||.||||||:::|.||..||.||.  |.....||......::.|.        .
Human   125 KDVLAWVK-KRRRTIRREDLISFLCGKVPPPRNSRAPPRLTVVSPNRATSTETSSSVETDLQPFR 188

  Fly   168 SGLGFHGSGLGLTGGPLTAAGGG---HLLSAGAAGGRQEGTGGAPGGGIGDDLHTFKEALVLRPR 229
            ..:..||....:....:.::..|   |:.|...|..|:.|            ||..
Human   189 EAIALHGLSGAMASISVRSSTPGSPTHVSSGSNASRRRNG------------LHDV--------- 232

  Fly   230 GPELLAFVANEIARHCKRPGS 250
              :|..|::.|:|.|....|:
Human   233 --DLNTFISEEMALHLDNGGT 251

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4768	NP_573164.2	DUF4588	15..>157	CDD:464591	66/151 (44%)
HAPSTR1	NP_054836.2	DUF4588	25..273	CDD:464591	83/257 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	32..51		3/18 (17%)
		HUWE1-binding and HAPSTR1 oligomerization (HBO) domain. /evidence=ECO:0000269|PubMed:35776542	80..152		38/72 (53%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	155..181		6/25 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	204..227		5/22 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	250..275		1/2 (50%)