DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sap30 and SAP30L

DIOPT Version :9

Sequence 1:	NP_001285352.1	Gene:	Sap30 / 32664	FlyBaseID:	FBgn0030788	Length:	173	Species:	Drosophila melanogaster
Sequence 2:	NP_078908.1	Gene:	SAP30L / 79685	HGNCID:	25663	Length:	183	Species:	Homo sapiens

Alignment Length:	178	Identity:	99/178 - (55%)
Similarity:	130/178 - (73%)	Gaps:	17/178 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 NGFSTGEEDSR------------GHTDQTCCLIDDMERCRNQAGYASYSKRIQKTVAQKRLKLSS 55
            ||||| |||||            |: .|:||||:|.|||...||.||:|||:||:::||:|||..
Human     2 NGFST-EEDSREGPPAAPAAAAPGY-GQSCCLIEDGERCVRPAGNASFSKRVQKSISQKKLKLDI 64

  Fly    56 DPAAQHIYICDHHKERIQSVRTKRRRKDSED--DSNETDTDLHEFPDLYQLGVSTLRRYKRHFKV 118
            |.:.:|:||||.||..|||||.||:||.|:|  ||.|.|||:.|. ||:||.|:||||||||:|:
Human    65 DKSVRHLYICDFHKNFIQSVRNKRKRKTSDDGGDSPEHDTDIPEV-DLFQLQVNTLRRYKRHYKL 128

  Fly   119 QTRQGMKRAQLADTIMKHFKTIPIKEKEIITFFVYMVKMGSNKLDQKN 166
            |||.|..:||||:|:.:||:.||:.|||.:.:|:||||...::||||:
Human   129 QTRPGFNKAQLAETVSRHFRNIPVNEKETLAYFIYMVKSNKSRLDQKS 176

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sap30	NP_001285352.1	zf-SAP30	16..86	CDD:404707	41/69 (59%)
Sap30	NP_001285352.1	SAP30_Sin3_bdg	104..156	CDD:404708	30/51 (59%)
SAP30L	NP_078908.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23		10/21 (48%)
		zf-SAP30	24..95	CDD:404707	42/71 (59%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	85..105		11/19 (58%)
		Nuclear localization signal (NLS). /evidence=ECO:0000305\|PubMed:14680513	86..91		2/4 (50%)
		Important for DNA and phosphoinositide binding. /evidence=ECO:0000269\|PubMed:19015240	88..90		1/1 (100%)
		SAP30_Sin3_bdg	114..166	CDD:404708	30/51 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143478
Domainoid	1	1.000	94	1.000	Domainoid score	I7487
eggNOG	1	0.900	-	-		E1_28PSY
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11632
Inparanoid	1	1.050	190	1.000	Inparanoid score	I3889
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48250
OrthoDB	1	1.010	-	-		D1520155at2759
OrthoFinder	1	1.000	-	-		FOG0004254
OrthoInspector	1	1.000	-	-		otm42090
orthoMCL	1	0.900	-	-		OOG6_106692
Panther	1	1.100	-	-	LDO	PTHR13286
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4744
SonicParanoid	1	1.000	-	-		X2991
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800