DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sap30 and Sap30l

DIOPT Version :9

Sequence 1:	NP_001285352.1	Gene:	Sap30 / 32664	FlyBaseID:	FBgn0030788	Length:	173	Species:	Drosophila melanogaster
Sequence 2:	NP_001074637.1	Gene:	Sap30l / 50724	MGIID:	1354709	Length:	182	Species:	Mus musculus

Alignment Length:	177	Identity:	98/177 - (55%)
Similarity:	128/177 - (72%)	Gaps:	16/177 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 NGFSTGEEDSR-----------GHTDQTCCLIDDMERCRNQAGYASYSKRIQKTVAQKRLKLSSD 56
            ||||| |||||           |: .|:||||.|.|||...||.||:|||:||:::||:|||..|
Mouse     2 NGFST-EEDSREGPPAAPAAAPGY-GQSCCLIADGERCVRPAGNASFSKRVQKSISQKKLKLDID 64

  Fly    57 PAAQHIYICDHHKERIQSVRTKRRRKDSED--DSNETDTDLHEFPDLYQLGVSTLRRYKRHFKVQ 119
            .:.:|:||||.||..|||||.||:||.|:|  ||.|.|.|:.|. ||:||.|:||||||||:|:|
Mouse    65 KSVRHLYICDFHKNFIQSVRNKRKRKASDDGGDSPEHDADIPEV-DLFQLQVNTLRRYKRHYKLQ 128

  Fly   120 TRQGMKRAQLADTIMKHFKTIPIKEKEIITFFVYMVKMGSNKLDQKN 166
            ||.|..:||||:|:.:||:.||:.|||.:.:|:||||...::||||:
Mouse   129 TRPGFNKAQLAETVSRHFRNIPVNEKETLAYFIYMVKSNRSRLDQKS 175

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sap30	NP_001285352.1	zf-SAP30	16..86	CDD:404707	41/69 (59%)
Sap30	NP_001285352.1	SAP30_Sin3_bdg	104..156	CDD:404708	30/51 (59%)
Sap30l	NP_001074637.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22		10/20 (50%)
		zf-SAP30	25..94	CDD:290577	41/68 (60%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	84..103		10/18 (56%)
		Nuclear localization signal (NLS). /evidence=ECO:0000250\|UniProtKB:Q9HAJ7	85..90		2/4 (50%)
		Important for DNA and phosphoinositide binding. /evidence=ECO:0000250\|UniProtKB:Q9HAJ7	87..89		1/1 (100%)
		SAP30_Sin3_bdg	114..162	CDD:290578	27/47 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167833633
Domainoid	1	1.000	92	1.000	Domainoid score	I7586
eggNOG	1	0.900	-	-		E1_28PSY
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11632
Inparanoid	1	1.050	186	1.000	Inparanoid score	I3914
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48250
OrthoDB	1	1.010	-	-		D1520155at2759
OrthoFinder	1	1.000	-	-		FOG0004254
OrthoInspector	1	1.000	-	-		otm44144
orthoMCL	1	0.900	-	-		OOG6_106692
Panther	1	1.100	-	-	LDO	PTHR13286
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4744
SonicParanoid	1	1.000	-	-		X2991
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	16.800