DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment if and ITGA10

DIOPT Version :9

Sequence 1:	NP_001162777.1	Gene:	if / 32661	FlyBaseID:	FBgn0001250	Length:	1396	Species:	Drosophila melanogaster
Sequence 2:	XP_016858111.1	Gene:	ITGA10 / 8515	HGNCID:	6135	Length:	1181	Species:	Homo sapiens

Alignment Length:	972	Identity:	236/972 - (24%)
Similarity:	382/972 - (39%)	Gaps:	230/972 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 PSY---VRFRQSSNSMFGFSIAMHKGRSGFYGNQNNVSLIVGAPKFDTSRYQQGVTEAG--GVFK 96
            |:|   |.....|||::.:|..           |..:..:||....|..:.|.|:.:.|  .|.:
Human   177 PTYMDVVIVLDGSNSIYPWSEV-----------QTFLRRLVGKLFIDPEQIQVGLVQYGESPVHE 230

  Fly    97 CSLNDDDCKLVPFDSKGNNRNVDKEVVDRKSYQWLGATVATGRDSD----LVVACAPRY-VFHTM 156
            .||.|       |.:|.......|.:..|:           ||::.    ::|||...: ..|..
Human   231 WSLGD-------FRTKEEVVRAAKNLSRRE-----------GRETKTAQAIMVACTEGFSQSHGG 277

  Fly   157 TPSRAFRIDPVGTCFTSHNFEEFYEVSPCRTNNWGYHRQGSCQAG----FSAAINGNGSRLFIGA 217
            .|..| |:..|.|...||:.||.    |....        :|:||    :..|:.|:..|. ...
Human   278 RPEAA-RLLVVVTDGESHDGEEL----PAALK--------ACEAGRVTRYGIAVLGHYLRR-QRD 328

  Fly   218 PGSWYWQGQTYSIPPDAKFPFK-------PPLYQPFGTG--GMASSHDVTRPENQV--------- 264
            |.|:..:.:|.:..||.:|.|.       ..:....|..  |:..||    .||:.
Human   329 PSSFLREIRTIASDPDERFFFNVTDEAALTDIVDALGDRIFGLEGSH----AENESSFGLEMSQI 389

  Fly   265 -FSTSE----------------------------------------SASVNDDSYLGYSMVTGDF 288
             |||..                                        .|..|..:|||||:.:...
Human   390 GFSTHRLKDGILFGMVGAYDWGGSVLWLEGGHRLFPPRMALEDEFPPALQNHAAYLGYSVSSMLL 454

  Fly   289 DGDRSEDVAIGMPR---GGNLV-------GRIVVNRWNMANIFNITGRQIGEYFGYSLATSDVDG 343
            .|.|...:: |.||   .|.::       |.:.|.:       ::.|.|||.|||..|...|.|.
Human   455 RGGRRLFLS-GAPRFRHRGKVIAFQLKKDGAVRVAQ-------SLQGEQIGSYFGSELCPLDTDR 511

  Fly   344 DGLDD-LLIGAPMYTDPDNVEGKYDVGRVYILLQGGP---TEEKRWTTEHIRDGYHSKGRFGLAL 404
            ||..| ||:.|||:..|.|.|    .||||:.|.|..   |.:.....|..:|     .|||.|:
Human   512 DGTTDVLLVAAPMFLGPQNKE----TGRVYVYLVGQQSLLTLQGTLQPEPPQD-----ARFGFAM 567

  Fly   405 TTLGDVNGDGYGDFAVGAPY-DGPEGRGVVYIFHGSPMGPLAKPSQIIKSEQLVEGAPYPRTFGF 468
            ..|.|:|.||:.|.|||||. ||.:  |.:|::||:..|....|:|.|.:..:.....|   ||.
Human   568 GALPDLNQDGFADVAVGAPLEDGHQ--GALYLYHGTQSGVRPHPAQRIAAASMPHALSY---FGR 627

  Fly   469 ALSGGLDMDGNTYPDLAVGAYSSDQVFIFKSRPVAAVNAETSFASNSKLISLDDRSCQLVRDHKK 533
            ::.|.||:||:...|:||||..:  ..:..|||:  |:...|.....:.||:..|.|:  |..::
Human   628 SVDGRLDLDGDDLVDVAVGAQGA--AILLSSRPI--VHLTPSLEVTPQAISVVQRDCR--RRGQE 686

  Fly   534 VPCMLLTTCWSYTGRYLPEQLD------FDVS---WLLDAKKLLNPRMFFLRDEGKNIRNQTIRL 589
            ..|:....|:..|.| .|.:.|      |..|   |...|:...:       ..|:.:..:.:||
Human   687 AVCLTAALCFQVTSR-TPGRWDHQFYMRFTASLDEWTAGARAAFD-------GSGQRLSPRRLRL 743

  Fly   590 NYGQKYCLNETVYLLDKVQDKLTPLEVEARYNL-RSSRPLDPMVRHRRSILEPVIDQNREIVLRD 653
            :.|...|.....::|| ..|.|.|:.:...:.| .:::|            .||:::.....::.
Human   744 SVGNVTCEQLHFHVLD-TSDYLRPVALTVTFALDNTTKP------------GPVLNEGSPTSIQK 795

  Fly   654 AINIQKNCGPDNICEPDLKLKVSTVD-----KYLF---GSPEPLVIEVFISNTNEDAFEAAFYMV 710
            .:...|:|||||.|..||.|:|: :|     |..|   |....:::...:.|..|:|:..:..::
Human   796 LVPFSKDCGPDNECVTDLVLQVN-MDIRGSRKAPFVVRGGRRKVLVSTTLENRKENAYNTSLSLI 859

  Fly   711 TPPDLQFRKLQQLGEKKDTPI--TCSPPTPENNHTLKCDIGNPL-ESGKIAHFKISLVPEEKYGS 772
            ...:|.   |..|..::::||  .|:.|:.   |...|.:|:|: ::|.    |::.:.|.::..
Human   860 FSRNLH---LASLTPQRESPIKVECAAPSA---HARLCSVGHPVFQTGA----KVTFLLEFEFSC 914

  Fly   773 SSSYDFYW---EANSTNLEKPGSEYDNKIRQSVGIWVDTDLDIKGTSLPDYQLYKADDY------ 828
            ||.....:   .|:|.:||:.|:..||..:.|..|..:..|.....|  ....|:...|
Human   915 SSLLSQVFVKLTASSDSLERNGTLQDNTAQTSAYIQYEPHLLFSSES--TLHRYEVHPYGTLPVG 977

  Fly   829 --KELENATKEDDIGPQVVHIYEIRNNRPSIIEEAEVFIHLPYETIVGDPLMYLLNQPETGG 888
              .|.:...:..::|..||....|....|::......|:.|. :.|..:....:.|..|..|
Human   978 PGPEFKTTLRVQNLGCYVVSGLIISALLPAVAHGGNYFLSLS-QVITNNASCIVQNLTEPPG 1038

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
if	NP_001162777.1	Int_alpha	46..110	CDD:214549	15/65 (23%)
		Int_alpha	275..>316	CDD:214549	13/50 (26%)
		Int_alpha	398..451	CDD:214549	24/53 (45%)
		Int_alpha	466..>497	CDD:214549	12/30 (40%)
		Integrin_alpha2	499..893	CDD:285619	93/422 (22%)
		DUF2756	<1120..1178	CDD:298627
ITGA10	XP_016858111.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141985
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740