DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment if and Itgae

DIOPT Version :9

Sequence 1:	NP_001162777.1	Gene:	if / 32661	FlyBaseID:	FBgn0001250	Length:	1396	Species:	Drosophila melanogaster
Sequence 2:	NP_113956.2	Gene:	Itgae / 83577	RGDID:	621644	Length:	1169	Species:	Rattus norvegicus

Alignment Length:	966	Identity:	202/966 - (20%)
Similarity:	348/966 - (36%)	Gaps:	279/966 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 RRRMALHCPITSLILLL---IAMSAHGYNIDLPSYVRFRQSSNSMFGFSIAMHKGRSGFYGNQ-- 67
            |:..:|:..:|....||   :.:.|..|..||...:....|.||            ..:||::
  Rat   117 RKPRSLNSELTGACSLLTPNLDLQAQAYFSDLEGVLDLGASVNS------------GDYYGSKGG 169

  Fly    68 --------------------------NNVSLIV-GAPKFDTSRYQQ------------------- 86
                                      ..::::: |:...:.|.:|:
  Rat   170 STGEETKSARRLRRQAVEEEDEEEAGTEIAIVLDGSGSIEPSDFQKAKDFISTMMRNFYEKCFEC 234

  Fly    87 --GVTEAGGVFKCSLNDDDCKLVPFDSKGNNRNVDK--EVVDRKSYQWLGATVATGRDSDLVVAC 147
              .:.:.|||.:...:       ..||:..|.::.|  .:|..|......:.:....|:..:.:.
  Rat   235 NFALVQYGGVIQTEFD-------LLDSRDINASLAKVQSIVQVKEVTKTASAMQHVLDNIFIPSR 292

  Fly   148 APR----YVFHTMTPSRAFRIDP---------------------VGTCFTSHN-FEEFYEVS--- 183
            ..|    .|...:|....|| ||                     ||..|.::| :.|...::
  Rat   293 GSRKKALKVMVVLTDGDIFR-DPLNLTTVISSSKMQGVVRFAIGVGNAFENNNTYRELKLIASDP 356

  Fly   184 ----PCRTNNWG-------------YHRQGS---------CQAGFSAAINGNGSRLFIGAPGSWY 222
                ..:..|:.             .|.:|:         .|.||||.|...| ::.:|..|::.
  Rat   357 KAAHTFKVTNYSALDGLLSKLQQRIIHMEGTVGDTLQYQLAQTGFSAQILDKG-QVLLGTVGAFN 420

  Fly   223 WQGQTYSIPPDAKFPFKPPLYQPFGTGGMASSHDVTRPENQVFSTSESASVNDDSYLGYSMVTGD 287
            |.|...             ||......|        |..||  :..|.......||||||:..
  Rat   421 WSGGAL-------------LYNTQNGRG--------RFLNQ--TAKEDFRAAQYSYLGYSVAA-- 460

  Fly   288 FDGDRSEDVAIGMPRGGNLVGRIV-VNRWNMANIF--NITGRQIGEYFGYSLATSDVDGDGLDD- 348
            ...........|.|| ..|.|.:. :.:.:....|  .|.|.|:|.|||..|...|::.||:.|
  Rat   461 LHKAHGVSYVAGAPR-HKLRGAVFELQKEDGEETFMRRIEGEQMGSYFGSVLCPVDINMDGITDF 524

  Fly   349 LLIGAPMYTDPDNVEGKYDVGRVYILL---QGGPTEEKRWTTEHIRDGYH--SKGRFGLALTTLG 408
            ||:.||.|    ::.|  :.||||:..   |..|     ::..:...||.  :..|||.|:..:|
  Rat   525 LLVAAPFY----HIRG--EEGRVYVYRVHEQDAP-----FSLVYTLSGYPGLTSSRFGFAMAAVG 578

  Fly   409 DVNGDGYGDFAVGAPYDG---PEGR--GVVYIFHGSPMGPLAKPSQIIKSEQLVEGAPYPRTFGF 468
            |:|.|.:.|.|:|||.:|   .:|.  |.|||::|...|..|.|||.|::..:..|..|   ||.
  Rat   579 DINQDKFTDVAIGAPLEGFGAGDGASYGSVYIYNGHSGGLHASPSQQIRASSVALGLYY---FGM 640

  Fly   469 ALSGGLDMDGNTYPDLAVGAYSSDQVFIFKSRPVAAVNAETSFASNSKLISLDDRSCQLVRDHKK 533
            ::|||||..|:...|:.||  |.|...:.:||||..:....:|..::..::..|:
  Rat   641 SVSGGLDFSGDDLADITVG--SQDVAVVLRSRPVVDLTVSMTFTPDALPMAFKDK---------- 693

  Fly   534 VPCMLLTTCWSYTGRYLPEQ-------LDFDVSWLLDAKKLLNPRMFFLRDEGKNIRNQTIRLNY 591
               |.:..|:......:|.:       |:|.|.  :|..|                  |..||..
  Rat   694 ---MDVELCFKVDSSAVPSEPGLRGMSLNFTVD--VDVTK------------------QKQRLQC 735

  Fly   592 GQKYC-------------LNETVYLLDKVQ-----DKLTPLEVEARYNLRSSRPLDPMVRHRRSI 638
            ..:.|             |.|...|:...:     |..:.:.::..|..::|       ..||:.
  Rat   736 ADRSCCQSCLMKWSGGSSLCEHFGLISTEEELCEDDCFSNITIKVSYEFQTS-------EERRNH 793

  Fly   639 LEPVIDQNREIVLRDAINIQKNCGPDNICEPDLKLKVSTVDKYL-FGSPEPLVIEVFISNTNEDA 702
            ..|::|..:|......:..:|:|.....|..:::|..:...:.| .|..:.:.:.:.::|:.||:
  Rat   794 PNPILDHYKEPSAIFQLPYEKDCKNKVFCIAEIQLTTAISQQDLVVGITKEVTMNISLTNSGEDS 858

  Fly   703 FEAAFYMVTPPDLQFRKLQQLGEKKDTP-ITCSPPTP-ENNHTLKCDIGNPLESGKIAHFKISLV 765
            :.....:..|.:|||:|:|    |..:| |.|..|.| .:...:.|.||:|:......:..::..
  Rat   859 YMTNMALNYPRNLQFKKIQ----KPLSPDIQCDDPKPVASVLVMNCKIGHPILKRSSVNVSVTWQ 919

  Fly   766 PEEKYGSSSSYDFYWEANSTN--------------------LEKPGSEYDNKIRQS 801
            .||....:.:.|.....:::|                    |.:|...|.|..:.|
  Rat   920 LEESIFPNRTADITVTISNSNEKSLARETHSLQFRHAFIAVLSRPSVMYMNTSQSS 975

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
if	NP_001162777.1	Int_alpha	46..110	CDD:214549	10/113 (9%)
		Int_alpha	275..>316	CDD:214549	11/41 (27%)
		Int_alpha	398..451	CDD:214549	25/57 (44%)
		Int_alpha	466..>497	CDD:214549	13/30 (43%)
		Integrin_alpha2	499..893	CDD:285619	63/351 (18%)
		DUF2756	<1120..1178	CDD:298627
Itgae	NP_113956.2	vWA_integrins_alpha_subunit	196..373	CDD:238746	26/184 (14%)
		Int_alpha	503..559	CDD:214549	21/66 (32%)
		Int_alpha	568..626	CDD:214549	25/57 (44%)
		Integrin_alpha2	669..>952	CDD:285619	58/326 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335707
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D743479at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.750