DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment if and Itga7

DIOPT Version :9

Sequence 1:	NP_001162777.1	Gene:	if / 32661	FlyBaseID:	FBgn0001250	Length:	1396	Species:	Drosophila melanogaster
Sequence 2:	NP_110469.1	Gene:	Itga7 / 81008	RGDID:	71022	Length:	1135	Species:	Rattus norvegicus

Alignment Length:	957	Identity:	267/957 - (27%)
Similarity:	440/957 - (45%)	Gaps:	168/957 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 CPITSLILL-LIAMSAHGYNIDLPSYVRFRQSSNSMFGFSIAMHKGRSGFYGNQNNVSLIVGAPK 78
            |.:.|.:|. |:...|..:|:|:...:|......|:||||:|:|:...    .:....|:||||:
  Rat    16 CYLLSFLLAGLLLPRASAFNLDVMGAIRKEGEPGSLFGFSVALHRQLQ----PRPQSWLLVGAPQ 76

  Fly    79 FDTSRYQQGVTEAGGVFKC--SLNDDDCKLVPFDSKGNNRNVDKEVVDRKSYQWLGATVATGRDS 141
            ......|| ....||:|.|  ||.:.||..|..|   ...||.||   .|..||||.:|.:....
  Rat    77 ALALPGQQ-ANRTGGLFACPLSLEETDCYRVDID---RGANVQKE---SKENQWLGVSVRSQGAG 134

  Fly   142 DLVVACAPRYVFHTMTPSRAFRIDPVGTCFT-SHNFEEFYEVSP-----CRTNNWGYHRQGSCQA 200
            ..||.||.||.............|.:|.||. |.:.....|:..     |.....|:.:.|.||.
  Rat   135 GKVVTCAHRYESRQRVDQVLETRDVIGRCFVLSQDLAIRDELDGGEWKFCEGRPQGHEQFGFCQQ 199

  Fly   201 GFSAAINGNGSRLFIGAPGSWYWQGQTYSIPPDAKFPFKPPLYQPFGTGGMASSHDVTRPENQVF 265
            |.:|..:.:...|..||||::.|:|..:                       .::.|.:.|:..|:
  Rat   200 GTAATFSPDSHYLIFGAPGTYNWKGLLF-----------------------VTNIDSSDPDQLVY 241

  Fly   266 STSESA--------SVNDDSYLGYSMVTGDFDG-DRSEDVAI--GMPRGGNLVGRIVVNRWNMAN 319
            .|.:.|        .:..:||||:|:.:|  .| .|||:::.  |.|| .|..|.:|:.|.:.|:
  Rat   242 KTLDPADRLTGPAGDLTLNSYLGFSIDSG--KGLMRSEELSFVAGAPR-ANHKGAVVILRKDSAS 303

  Fly   320 IF----NITGRQIGEYFGYSLATSDVDGDGLDDLLIGAPMYTDPDNVEGKYDVGRVYILL-QGGP 379
            ..    .::|.::...||||||.:|::.||..||::|||.:.:.....|    |.||:.: |||
  Rat   304 RLIPEVVLSGERLTSGFGYSLAVTDLNSDGWADLIVGAPYFFERQEELG----GAVYVYMNQGG- 363

  Fly   380 TEEKRWT-TEHIRDGYHSKGRFGLALTTLGDVNGDGYGDFAVGAPYDGPEGRGVVYIFHGSPMGP 443
                .|. ...:|........||::|..|||:|.||:.|.|||||:||.   |.|:|:|||.:|.
  Rat   364 ----HWADISPLRLCGSPDSMFGISLAVLGDLNQDGFPDIAVGAPFDGD---GKVFIYHGSSLGV 421

  Fly   444 LAKPSQIIKSEQLVEGAPYPRTFGFALSGGLDMDGNTYPDLAVGAYSSDQVFIFKSRPVAAVNAE 508
            :.||||:::.|     |...::||::||||||:|||.||||.||:. :|...:|::|||..|:.|
  Rat   422 VTKPSQVLEGE-----AVGIKSFGYSLSGGLDVDGNHYPDLLVGSL-ADTAALFRARPVLHVSQE 480

  Fly   509 TSFASNSKLISLDDRSC---QLVRDHKKVPCMLLTTCWSYT---GRYLPEQLDFDVSWLLDA--- 564
            ...  :.:.|.|:..:|   :||..|.||       |:||.   ..|.|..:   :.::||.
  Rat   481 IFI--DPRAIDLEQPNCADGRLVCVHVKV-------CFSYVAVPSSYSPIVV---LDYVLDGDTD 533

  Fly   565 KKLLN--PRMFFL---RDEGKNIRNQTIRLNYGQKYCLNETVY-LLDKVQDKLTPLEVEARYNLR 623
            ::|..  ||:.|.   .|:.|:..:.|:.|.:.......:||: |.:.|:|||..:.|...|.|:
  Rat   534 RRLRGQAPRVTFPGRGPDDLKHQSSGTVSLKHQHDRVCGDTVFQLQENVKDKLRAIVVTLSYGLQ 598

  Fly   624 SSRPLDPMVRHRR-----SILEPVIDQNREIVLRDAIN-IQKNCGPDNICEPDLKL-------KV 675
            :     |.:|.:.     .::.|:::.::....|..|: :::.||.|.||:.:|:|       ::
  Rat   599 T-----PRLRRQAPDQGLPLVAPILNAHQPSTQRTEIHFLKQGCGDDKICQSNLQLAQAQFCSRI 658

  Fly   676 STVD----------KYLFG-SPEPLV-IEVFISN----------TNEDAFEAAFYMVTPPDLQFR 718
            |..:          ..||. |.:|.: :|:.::|          ..:||.||......|..|::.
  Rat   659 SDTEFQALPMDLDGTALFALSGQPFIGLELTVTNLPSDPARPQADGDDAHEAQLLATLPASLRYS 723

  Fly   719 KLQQLGEKKDTPITCSPPTPENNHTLKCDIGNPLESGKIAHFKISLVPEEKYGSSSSYDFYWEAN 783
            .::.| :..:.|:..|   .||...::|::|||::.|....|.:.|       |:|....  |..
  Rat   724 GVRTL-DSVEKPLCLS---NENASHVECELGNPMKRGTQVTFYLIL-------STSGITI--ETT 775

  Fly   784 STNLE---KPGSEYD-NKIRQSVGIWVDTDLDIKGTSLPDYQLYKADDYKELENATKEDDIGPQV 844
            ...:|   ...||.| :.:.....::::..|.|.|.:.|. ||:.:...|.......|.|:|.:|
  Rat   776 ELKVELLLATISEQDLHPVSVRAHVFIELPLSISGVATPQ-QLFFSGKVKGESAMRSERDVGSKV 839

  Fly   845 VHIYEIRNNRPSIIEEAEVFIHL--PYETIVGDPLMYLLNQPETGGK 889
            .:...:.|...|:......|:::  |:|...|..|:|.:.....||:
  Rat   840 KYEVTVSNQGQSLNTLGSAFLNIMWPHEIANGKWLLYPMRVELEGGQ 886

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
if	NP_001162777.1	Int_alpha	46..110	CDD:214549	23/65 (35%)
		Int_alpha	275..>316	CDD:214549	17/43 (40%)
		Int_alpha	398..451	CDD:214549	28/52 (54%)
		Int_alpha	466..>497	CDD:214549	18/30 (60%)
		Integrin_alpha2	499..893	CDD:285619	103/447 (23%)
		DUF2756	<1120..1178	CDD:298627
Itga7	NP_110469.1	FG-GAP 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	38..103		21/69 (30%)
		Int_alpha	48..109	CDD:214549	23/65 (35%)
		FG-GAP 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	110..165		19/57 (33%)
		FG-GAP 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	185..238		15/75 (20%)
		FG-GAP 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	248..305		18/59 (31%)
		Int_alpha	260..311	CDD:214549	18/53 (34%)
		FG-GAP 5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	306..367		23/69 (33%)
		Int_alpha	318..371	CDD:214549	22/61 (36%)
		FG-GAP 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	368..423		25/57 (44%)
		Int_alpha	377..429	CDD:214549	28/54 (52%)
		FG-GAP 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	427..486		27/66 (41%)
		Int_alpha	439..>479	CDD:214549	23/40 (58%)
		Integrin_alpha2	471..960	CDD:285619	103/447 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	905..933
		GFFKR motif	1061..1065
		3 X 4 AA repeats of D-X-H-P	1111..1130
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335716
Domainoid	1	1.000	57	1.000	Domainoid score	I10607
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D325432at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.750