DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment if and Itga2b

DIOPT Version :9

Sequence 1:	NP_001162777.1	Gene:	if / 32661	FlyBaseID:	FBgn0001250	Length:	1396	Species:	Drosophila melanogaster
Sequence 2:	XP_001063315.1	Gene:	Itga2b / 685269	RGDID:	1596428	Length:	1037	Species:	Rattus norvegicus

Alignment Length:	1071	Identity:	304/1071 - (28%)
Similarity:	469/1071 - (43%)	Gaps:	179/1071 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 AMSAHGYNIDLPSYVRFRQSSNSMFGFSIAMHKGRSGFYGNQNNVSLIVGAPKFDTSRYQQGVTE 90
            |..|...|:|...:..:...:.|.||||:..||...|      :||::||||:...:..:    |
  Rat    26 APPAWALNLDSVKFSVYTGPNGSHFGFSVDFHKDSHG------SVSIVVGAPRALNANQE----E 80

  Fly    91 AGGVFKC--SLNDDDCKLVPFDSKGNNRNVDKEVVDR-KSYQWLGATVATGRDSDLVVACAPRYV 152
            .||||.|  ..|:..|..:.||.:...|.:..:.... |:.|.|||:|.:.  :|::|||||...
  Rat    81 TGGVFLCPWKANNGTCTSLLFDLRDETRKLSLQTFQTFKTGQGLGASVLSW--NDVIVACAPWQH 143

  Fly   153 FHTMTPSRAFRIDPVGTCFTSHNFEEFY-----EVSPCRTNNW-GYHRQG------SCQAGFSAA 205
            ::.:.........|||.||.:    |..     |.||||:|.. ..:.||      .|:||||.|
  Rat   144 WNVLEKYDEAEKTPVGGCFVA----ELQSGGRAEYSPCRSNTMSSVYSQGFSGDKRYCEAGFSLA 204

  Fly   206 INGNGSRLFIGAPGSWYWQGQTYSIPPDAKFPFKPPLYQPFGTGGMASSHDVTRP-------ENQ 263
            :...| .|.:||||.:::.|....:|.:                .:.||:   ||       .||
  Rat   205 VTQAG-ELVLGAPGGYFFLGLLVRVPIE----------------NIISSY---RPGTLLWHVSNQ 249

  Fly   264 VFSTSESASVNDDSYLGYSMVTGDFDGDRS-EDVAIGMPRGGNLVGRIVVNRWNMANIFNITGRQ 327
            .||...|..|....|.|||:..|:||||.| .:...|.|.....:|.:.:.......:..:.|.|
  Rat   250 RFSYDSSNPVYFHGYRGYSVAVGEFDGDLSTTEYIFGAPTWSWTLGAVEILDSYYQTLHRLHGEQ 314

  Fly   328 IGEYFGYSLATSDVDGDGLDDLLIGAPMYTDPDNVEGKY-DVGRVYILLQ-------GGPTEEKR 384
            :..|||:|:|.:||:|||..|||:|||:|.: ..|:.|. :|||||:.||       ..||
  Rat   315 MASYFGHSVAVTDVNGDGRHDLLVGAPLYME-SRVDRKLAEVGRVYLFLQPKGLQALSSPT---- 374

  Fly   385 WTTEHIRDGYHSKGRFGLALTTLGDVNGDGYGDFAVGAPYDGPEGRGVVYIFHGSPMGPLAKPSQ 449
                .:..|....||||.|:..|||:|.|||.|.||.|||.||.|:|.|.||.|...|...:|||
  Rat   375 ----LVLTGTQVYGRFGSAIAPLGDLNRDGYNDVAVAAPYGGPSGQGQVLIFLGQSEGLSPRPSQ 435

  Fly   450 IIKSEQLVEGAPYP--RTFGFALSGGLDMDGNTYPDLAVGAYSSDQVFIFKSRPV--AAVNAETS 510
            ::.|       |:|  ..|||:|.|.:|:|.|.||||.||||.:.:|.:::::||  |.|.....
  Rat   436 VLDS-------PFPTGSGFGFSLRGSVDIDDNGYPDLIVGAYGASKVAVYRAQPVVMATVQLMVQ 493

  Fly   511 FASNSKLISLDDRSCQLVRDHKKVPCMLLTTCWSYTGRYLPEQLDFDVSWLLDAKKLLNPRMFFL 575
            .:.|..|     ::|.|.:....|.|..:..|...||..:|::|.......||.:|....|...|
  Rat   494 DSLNPTL-----KNCVLEQTKTPVSCFNVQMCVGATGHNIPQKLHLKAELQLDLQKPRQARRVLL 553

  Fly   576 RDEGKNIRNQTIRLNYG---QKYCLNETVYLLDKV--QDKLTPLEVEARYNLRSSRP-LDPMVRH 634
            .  .....:.|:.|:.|   :..|.....:|.|:.  :|||:|:.:....:|..... :.|.|
  Rat   554 L--ASRQASLTLSLDLGGRNKPICHTIKAFLRDEADFRDKLSPIVLSLNVSLPPEETGVAPAV-- 614

  Fly   635 RRSILEPV--IDQNREIVLRDAINIQKNCGPDNICEPDLKLKVSTVDK-YLFGSPEPLVIEVFIS 696
               :|..|  :.:...|:|        :||.||:|.|.|:|..:..|. .|.|:...|.::|..|
  Rat   615 ---VLHGVTHVQEQTRIIL--------DCGEDNLCVPQLQLTATAGDSPLLIGADNVLELKVNAS 668

  Fly   697 NTNEDAFEAAFYMVTPPDLQF-RKLQQLGEKKDTPITCSPPTPENNHTLKCDIGNPLESGKIAHF 760
            |..|.|:||...:..||...: |....:  |....:.|:......:....|::|||::  |....
  Rat   669 NDGEGAYEAELAVHLPPGAHYIRAFSNV--KGFERLVCTQKKENESRLALCELGNPMK--KDTRI 729

  Fly   761 KISLVPE----EKYGSSSSYDFYWEANSTNLEKPGSEYDNKIRQSVGIWVDTDLDIKGTSLPDYQ 821
            .|:::..    |:.|.|.|  |..:..|.|.:.|.||   .:...|.:..:..::::|.|.|...
  Rat   730 GITMLVSVEILEEAGDSVS--FQLQIRSKNSQNPNSE---AVLLPVAVRAEAAVELRGNSFPASL 789

  Fly   822 LYKADDYKELENATKEDDIGPQVVHIYEIRNNRPSIIEEAEVFIHLPYETIVGDPLMYLLNQPET 886
            :..|::..:.::..  |....:|.|.||:.||.|..:....:.||||.::...| |:|:|:....
  Rat   790 VVAAEEVDKEQDGL--DSWVSRVEHTYELHNNGPGTVNGLSLIIHLPGQSQPSD-LLYILDVQPK 851

  Fly   887 GGKIQCDDVAFNEYNLLLDEKLVKKSYLQAQGAIWNSAQVSGQSSSSSSSGGASVHIEKARGEGF 951
            || :.|....        ..||:|               |..:.::.|.|....:|.::.|.|..
  Rat   852 GG-LLCSTQP--------PPKLLK---------------VDRRLTTPSPSSIRRIHHDRDRREAS 892

  Fly   952 VRGVLVSNSTDAGDKL-------SP---------KQVEQRRQEDTLEA-LGDASFVHRDRASQAV 999
            .:|   |..|:..|.:       :|         :.|..:|...|::| ||.:....|.:....:
  Rat   893 PQG---SKQTEQQDPVLVSCNGSAPCTVVECELQEMVRGQRAMVTVQATLGLSILRQRPQEQFVL 954

  Fly  1000 QEPQVNQTSFTTYSTS--SSSSGSGAPSAQL 1028
            |.......|...||..  |..||.|.....|
  Rat   955 QSHAWFNVSSLPYSVPVVSLPSGQGLVQTHL 985

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
if	NP_001162777.1	Int_alpha	46..110	CDD:214549	22/65 (34%)
		Int_alpha	275..>316	CDD:214549	13/41 (32%)
		Int_alpha	398..451	CDD:214549	30/52 (58%)
		Int_alpha	466..>497	CDD:214549	17/30 (57%)
		Integrin_alpha2	499..893	CDD:285619	100/409 (24%)
		DUF2756	<1120..1178	CDD:298627
Itga2b	XP_001063315.1	Int_alpha	46..102	CDD:214549	22/65 (34%)
		Int_alpha	315..375	CDD:214549	28/68 (41%)
		Int_alpha	383..437	CDD:214549	30/53 (57%)
		Int_alpha	444..>484	CDD:214549	18/39 (46%)
		Integrin_alpha2	480..920	CDD:285619	115/498 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335769
Domainoid	1	1.000	132	1.000	Domainoid score	I4971
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	492	1.000	Inparanoid score	I1353
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D325432at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm45551
orthoMCL	1	0.900	-	-		OOG6_102088
Panther	1	1.100	-	-	O	PTHR23220
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X587
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.760