DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment if and itga10

DIOPT Version :9

Sequence 1:	NP_001162777.1	Gene:	if / 32661	FlyBaseID:	FBgn0001250	Length:	1396	Species:	Drosophila melanogaster
Sequence 2:	XP_003200204.1	Gene:	itga10 / 572348	ZFINID:	ZDB-GENE-100922-54	Length:	1170	Species:	Danio rerio

Alignment Length:	1074	Identity:	246/1074 - (22%)
Similarity:	406/1074 - (37%)	Gaps:	316/1074 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 LILLLIAMSAHG----YNIDLPSYVRFRQSSNSMFGFSIAMHKGRSGFYGNQNNVSLIVGAPKFD 80
            |:|..|.:...|    :|||:.....|....:::||||:..|       .:.....|:|||| :|
Zfish     7 LLLFKITILLKGLCECFNIDVKRPRIFSGPEDALFGFSVLQH-------DDNGEKLLLVGAP-WD 63

  Fly    81 TSRYQQGVTEAGGVFKCSLNDD--DCKLVPFDSKGNN--RNVDKEVVDRKSYQWLGATVATGRDS 141
            ..:..:    .|.::||.:.|:  :|..|   :.|.|  :||.:.:  :.|:  ||.|: |..||
Zfish    64 GPQNNR----KGDIYKCIVEDENSNCSKV---NLGENAFQNVSRNL--KNSH--LGMTL-TPTDS 116

  Fly   142 DLVVACAPRY-------VFHT---------MTPSRAFRIDPVG-TCFT----------SHNFEEF 179
            |..:||||.:       :|.|         |.|:..  |.|.. .|.|          |::...:
Zfish   117 DGFLACAPLWSQECGTSLFSTGICASVTSDMEPNDV--IAPTAQRCTTYMDIVIVLDGSNSIYPW 179

  Fly   180 YEVSPCRTN-------------------------NW----------------------------G 191
            |||....:|                         .|                            .
Zfish   180 YEVQNFLSNILSKFHISPEQMQVGVLQYGEISVHEWSLRDYQTTADVVEAAKNISRQEGRETRTA 244

  Fly   192 YHRQGSCQAGFS---AAING-----------------------------NGSRLFIGAPGSWYWQ 224
            |..|.:|...||   .|..|                             |.:|..|...|.:..:
Zfish   245 YAIQMACTEAFSPDRGAREGATKVMIVVTDGESHDGEDLPEALIECEKRNITRYAIAVLGHYIRR 309

  Fly   225 GQ---TY-------SIPPDAKFPFKPPLYQPFGTGGMASSHDVTRPENQVFST------SESASV 273
            .|   |:       |..||.|:.|..       |...|.:..|....:::||.      :|||.:
Zfish   310 QQDPETFINEIKYISSDPDEKYFFNV-------TDEAALNDIVDALGDRIFSLEGTLGYNESAFL 367

  Fly   274 NDDSYLGYSM----------VTGDFDGD-----RSEDVAIGMPRG-----------------GNL 306
            .:.|.:|:|.          :.|.:|.:     .|::..:..||.                 |..
Zfish   368 MEMSQIGFSTHILDDGILFGMVGAYDWEGGILKESKEGQLMPPREAFEKEFPLELKNHAAYLGYT 432

  Fly   307 VGRIVVNRWNMANI--------------FNIT------------GRQIGEYFGYSLATSDVDGDG 345
            |..:||..|....:              |::|            |.|||.|||..:...|||.||
Zfish   433 VSSVVVGNWRRLYVAGAPRFKHKGKVILFDLTPEGDVIITQALNGEQIGSYFGSEVCVVDVDQDG 497

  Fly   346 LDD-LLIGAPMYTDPDNVEGKYDVGRVYILLQGGPTEEKRWTTEHIRDGY------HSK-----G 398
            :.| |||.|||:....|.|    .|:||:....|             ||:      ||:     .
Zfish   498 ITDILLIAAPMFLGAGNKE----TGKVYVFCLDG-------------DGFAPNGTLHSQQKAQDA 545

  Fly   399 RFGLALTTLGDVNGDGYGDFAVGAPYDGPEGRGVVYIFHGSPMGPLAKPSQIIKSEQLVEGAPYP 463
            |||.|:....|:|.|||.|..||||.: .:.:|.:||:||.....:.:..|.|....|..|..|
Zfish   546 RFGYAMAVAPDLNHDGYTDLLVGAPLE-DDHQGALYIYHGDEYYIIPQYKQRISGSSLSTGLRY- 608

  Fly   464 RTFGFALSGGLDMDGNTYPDLAVGAYSSDQVFIFKSRPVAAVNAETSFASNSKLISLDDRSCQLV 528
              ||.:||..||:||:...||||||..|  ..:.|||.:..:|...||..:|  |::..::|  :
Zfish   609 --FGRSLSALLDLDGDELLDLAVGAQGS--AVLLKSRSIVQINVSLSFQPHS--INVIQKNC--L 665

  Fly   529 RDHKKVPCMLLTTCW-------SYTGRYLPEQLDFDVSWLLDAKKLLNPRMFFLRDEGKNIRNQT 586
            |..:...|:..|.|:       ...|.|    .|..|..:||.:|:....:|....:.:.:.:.:
Zfish   666 RAGRDSACLNATVCFLALSRSPGSRGTY----FDMQVGAMLDDRKISARALFDSNSQRQTLMSIS 726

  Fly   587 IRLNYGQKYCLNETVYLLDKVQDKLTPLEVEARYNLRSSRPLDPMVRHRRSILEPVIDQNREIVL 651
            :|:  |:..|.....::.| ..|.:.|:....|:.:..:..            .||:|:......
Zfish   727 VRV--GETKCYILPFHVFD-TADYIRPISFTLRFKINDTES------------GPVLDEGWPTTH 776

  Fly   652 RDAINIQKNCGPDNICEPDLKLKVSTVD-------KYLFGSP-EPLVIEVFISNTNEDAFEAAFY 708
            :.:|...|:||.|::|..||.|: :.:|       .|:..|| ..|.:||.:.|..|:|:..:..
Zfish   777 KKSIPFFKDCGEDDVCVTDLVLQ-AHMDISGTRQVPYVIRSPRRRLAVEVQLQNKLENAYNTSLT 840

  Fly   709 MVTPPDLQFRKLQQLGEKKDTPITCSPPTPENNHTLKCDIGNPLESGKIAHFKISLVPEEKYGSS 773
            :....:|.|..| .:.|.....|.|: ....|:|:  |::..|:..   :..|::.:.|.::..:
Zfish   841 LHYSKNLHFSTL-SIREDAQFKIECT-ALGSNSHS--CNVSYPVFR---SQSKVNFMLEFEFSCT 898

  Fly   774 ---SSYDFYWEANSTNLEKPGSEYDNKIRQSVGIWVDTDLDIKGTS-LPDYQLYKADDYKELENA 834
               |.......|:|.::|:.|:..||.::....:..:.||.|...| |..|:::        ...
Zfish   899 SLISKVQMRLIASSDSVEREGTLSDNTVQLQSIVQYEPDLFITSDSNLNRYEVH--------PTR 955

  Fly   835 TKEDDIGPQVVHIYEIRNNRPSIIEEAEVFIHLP 868
            |..:..||:....:.::|.....:...|:.:.||
Zfish   956 TASEGTGPEFYTHFRVQNLGCYAVSNLELSVSLP 989

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
if	NP_001162777.1	Int_alpha	46..110	CDD:214549	17/65 (26%)
		Int_alpha	275..>316	CDD:214549	12/72 (17%)
		Int_alpha	398..451	CDD:214549	20/52 (38%)
		Int_alpha	466..>497	CDD:214549	15/30 (50%)
		Integrin_alpha2	499..893	CDD:285619	81/389 (21%)
		DUF2756	<1120..1178	CDD:298627
itga10	XP_003200204.1	Int_alpha	38..88	CDD:214549	16/61 (26%)
		vWA_integrins_alpha_subunit	164..344	CDD:238746	26/186 (14%)
		Int_alpha	480..>523	CDD:214549	22/46 (48%)
		Int_alpha	543..597	CDD:214549	20/54 (37%)
		Integrin_alpha2	640..1056	CDD:285619	81/389 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574895
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740