DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment if and itga11b

DIOPT Version :9

Sequence 1:	NP_001162777.1	Gene:	if / 32661	FlyBaseID:	FBgn0001250	Length:	1396	Species:	Drosophila melanogaster
Sequence 2:	XP_695559.7	Gene:	itga11b / 567175	ZFINID:	ZDB-GENE-071009-4	Length:	1219	Species:	Danio rerio

Alignment Length:	1315	Identity:	276/1315 - (20%)
Similarity:	445/1315 - (33%)	Gaps:	474/1315 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 TSLILLLIAMSAHG----YNIDLPSYVRFRQSSNSMFGFSIAMHKGRSGFYGNQNNVSLIVGAPK 78
            |.|:||.::....|    :|||.......:.|..:.||:::..|:.       .....|:||||
Zfish    39 TYLLLLWVSALMPGPRTCFNIDTRRAKVIKGSREAQFGYTVQQHEA-------DGQKWLLVGAP- 95

  Fly    79 FDTSRYQQGVTEAGGVFKCSLNDDDCKLVPFDSKGNN---RNVDK----EVVDRKSYQWLGATVA 136
            |:||    |..:.|.|::|          |.:||..|   .::.|    .|.:|:....||.|:|
Zfish    96 FETS----GEHQTGDVYRC----------PLESKRTNCTRLHLGKISLNNVSERRDKMRLGMTLA 146

  Fly   137 TGRDSDLVVACAPRYVF----------------------HTMTPS-------------------- 159
            |....:..|||.|.:.:                      |::.|:
Zfish   147 TNPKDNSFVACGPLWSYECGSSYYSTGICSRVDSNFNFTHSIAPAYQRCETYMDIVIVLDGSNSI 211

  Fly   160 ------------------------------------RAFRIDP---------------------- 166
                                                ..||:|.
Zfish   212 YPWYEVQDFLINVLQKFYIGPGQIQVGVVQYGERVVNEFRLDDFRTVDEVVAAAKNIDQRGGEET 276

  Fly   167 ----------------------------------------------------------------- 166

Zfish   277 RTALGINVARTQAFKHGGRPDAKKVMIVITDGESHDSPDLKAAVEESEKDNITLYGIAVLGYYNR 341

  Fly   167 --------------VGTCFTSHNF----------------EEFYEVSPCRTNNWGYHRQGSCQAG 201
                          :.|....|.|                |:.:.:.....|...:..|.| |||
Zfish   342 RGINPEAFLREIKFIATDPDEHFFSVTDESALKDIVDALGEKIFSLEGTNQNGTAFGLQMS-QAG 405

  Fly   202 FSAAINGNGSRLFIGAPGSWYWQGQTYS-------IPPDAKFPFKPPLYQPFGTGGMASSHDVTR 259
            ||:.|..:|  :.:||.|::.|.|....       |||                   .||:....
Zfish   406 FSSHIVEDG--ILVGAVGAYDWNGAVLKETRHGKVIPP-------------------KSSYMKEF 449

  Fly   260 PENQVFSTSESASVNDDSYLGYSMVTGDFDGDRSEDVAIGMPRGGNLVGRIVV----NRWNMANI 320
            ||.         ..|..:|||| ||:........:....|.|| .|..|::|:    |..|:..:
Zfish   450 PEE---------LKNHGAYLGY-MVSSVVSAHHGQLYVAGAPR-FNHTGKVVIFTLTNSGNLTIL 503

  Fly   321 FNITGRQIGEYFGYSLATSDVDGDGLDD-LLIGAPMYTDPDNVEGKYDVGRVYIL---LQG---- 377
            :::.|:|||.|:|..||..|||.|||.| ||:|||||.    ..| ::.|:|||.   |||
Zfish   504 YSLYGKQIGSYYGSELAPIDVDDDGLTDLLLVGAPMYF----YRG-WEKGKVYIYTVGLQGSFIP 563

  Fly   378 ----GPTEEKRWTTEHIRDGYHSKGRFGLALTTLGDVNGDGYGDFAVGAPYDGPEGRGVVYIFHG 438
                ||       :||..|     .|||.|::.|.|:||||:.:..||||.: ...||.:|:|:|
Zfish   564 DGTLGP-------SEHSHD-----SRFGAAMSALPDLNGDGFSELVVGAPLE-DNHRGAIYLFYG 615

  Fly   439 SPMGPLAKPSQIIKSEQLVEG---APYPRTFGFALSGGLDMDGNTYPDLAVGAYSSDQVFIFKSR 500
                  .|.|...|.:|.:.|   ||..|.||.::.|.:|::|:...||:||::.:  ..:..||
Zfish   616 ------LKNSIQTKYKQRISGIELAPGLRYFGRSVHGMMDLNGDGLVDLSVGSFGA--AVLLWSR 672

  Fly   501 PVAAVNAETSFASNSKLISLDDRSCQLVRDHKKVPCMLLTTCWSYTGRYLPEQLDFDVSWLLDAK 565
            .|..|.....|..:.  |::.::.|  :|..::|.|||.|.|.:.|.|          :.:.|.|
Zfish   673 SVVRVGIGVHFEPSK--INVFNKDC--IRGGREVSCMLATVCLNVTAR----------TPMTDPK 723

  Fly   566 KLLNPRMFFLRDEG--------KNIRNQTIRLNYGQKYCLNETVYLLDKVQDKLTPLEVEARYNL 622
            ::.....|...:.|        ....::.:.|....::| .:..:.:.:|.|...||.......|
Zfish   724 RVALRYSFGFEETGYFPRAVLDSTEESRDVTLRPAAQHC-QQLHFHVHEVTDYTRPLTFTVNVGL 787

  Fly   623 RSSRPLDPMVRHRRSILEPVIDQNREIVLRDAINIQKNCGPDNICEPDLKLKVST---------- 677
                        :|:...||:|......||..:.....|..|:.|.|:|.|:.|:
Zfish   788 ------------QRADEGPVLDDGWPTSLRSELPFWNGCDNDDQCVPNLILQSSSDLLDLREFCS 840

  Fly   678 ----------VDKYLFGSPEPL--------VIEVFISNTNEDAFEAAFYMVTPPDLQFRKLQQLG 724
                      ||:....:||.|        |:|..:.|..|:|:.:..::...|:|.|..| .:.
Zfish   841 RDERSSWPPCVDQSSIKTPERLVESSRRKVVVETHLENRGENAYNSILHITHSPNLHFSSL-VVK 904

  Fly   725 EKKDTPITCSPPTPENNHTLKCDIGNP-LESGKIAHFKISLVPEEKYGSSSSYDFYWEANSTNLE 788
            ...|..|.| |.:.:.:....|::..| :.:....:|::      ::..|.|....:...|..:.
Zfish   905 APSDIAIEC-PNSDDTSLYRTCNVSAPFMRASAQVYFRL------EFEFSRSVFLNYVNISLRVS 962

  Fly   789 KPGSEY---DNKIRQSVGIWVDTDLDIKGTSLPDYQLYKADDYKELENATKEDDIGPQVVHIYEI 850
            ..|.|.   ||.......:..:.||.....|.|.....|.:..:.:...:     ||.....|:|
Zfish   963 SEGEEMFPEDNVNNIHHNLRYEADLLFTRDSSPSRFEIKPEQAQSVSVGS-----GPPFNLSYQI 1022

  Fly   851 RN-------------NRPSIIEEAEVFIHLPYETIVGDPLMYLLNQP----------ETGGKIQC 892
            :|             |..::..:|...:||      .|  :|:...|          ..|...|.
Zfish  1023 QNLGLFPVSELLFTLNVFAVTRKANTLLHL------SD--LYIQQMPGSLCSFPRVITAGSSSQE 1079

  Fly   893 DDVAFNEY-NLLLDEKLVKKSYLQAQGAIWNSAQVSGQSSSSSSSGGASVHIEKARGEGFVRGVL 956
            :|::.|.: |....:.|:    .|.:..:...|.|     |.:.:|..::|...|  ..|.|..|
Zfish  1080 EDLSLNAHMNASTSDALL----AQCRFNLSPQADV-----SITVTGWLNLHTLLA--VKFKRLDL 1133

  Fly   957 VSNSTDAGDKLSPKQ--------------VEQRRQED-----------TLE----------ALGD 986
            |..:|   .:|||..              :|.|::||           ||.          ||..
Zfish  1134 VMTAT---VELSPSNPMFLHEERPMRHIILEIRKEEDYRIPVWVIIGSTLGGLQLLALLVLALWK 1195

  Fly   987 ASFVHRDRASQAVQE 1001
            ..|.||.:..:..||
Zfish  1196 LGFFHRQKRKRDEQE 1210

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
if	NP_001162777.1	Int_alpha	46..110	CDD:214549	16/63 (25%)
		Int_alpha	275..>316	CDD:214549	13/44 (30%)
		Int_alpha	398..451	CDD:214549	21/52 (40%)
		Int_alpha	466..>497	CDD:214549	9/30 (30%)
		Integrin_alpha2	499..893	CDD:285619	87/456 (19%)
		DUF2756	<1120..1178	CDD:298627
itga11b	XP_695559.7	Int_alpha	73..123	CDD:214549	19/71 (27%)
		vWA_integrins_alpha_subunit	199..376	CDD:238746	6/176 (3%)
		Int_alpha	574..628	CDD:214549	24/65 (37%)
		Int_alpha	639..>665	CDD:214549	9/25 (36%)
		Integrin_alpha2	671..1071	CDD:312071	85/447 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574975
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.740