Protein Alignment if and itga11b

DIOPT Version :10

• Sequence 1: NP_523378.2
• Gene: if / 32661
• FlyBaseID: FBgn0001250
• Length: 1396
• Species: Drosophila melanogaster
• Sequence 2: XP_695559.9
• Gene: itga11b / 567175
• ZFINID: ZDB-GENE-071009-4
• Length: 1186
• Species: Danio rerio
• Alignment Length: 1338
• Identity: 275/1338 - (20%)
• Similarity: 447/1338 - (33%)
• Gaps: 520/1338 - (38%)

  Fly    18 TSLILLLIAMSAHG----YNIDLPSYVRFRQSSNSMFGFSIAMHKGRSGFYGNQNNVSLIVGAPK 78
            |.|:||.::....|    :|||.......:.|..:.||:::..|:.       .....|:||||
Zfish     6 THLLLLWVSALMPGPRTCFNIDTRRAKVIKGSREAQFGYTVQQHEA-------DGQKWLLVGAP- 62

  Fly    79 FDTSRYQQGVTEAGGVFKCSLNDDDCKLVPFDSKGNN---RNVDK----EVVDRKSYQWLGATVA 136
            |:||    |..:.|.|::|          |.:||..|   .::.|    .|.:|:....||.|:|
Zfish    63 FETS----GEHQTGDVYRC----------PLESKRTNCTRLHLGKISLNNVSERRDKMRLGMTLA 113

  Fly   137 TGRDSDLVVACAPRYVF----------------------HTMTPS-------------------- 159
            |....:..|||.|.:.:                      |::.|:
Zfish   114 TNPKDNSFVACGPLWSYECGSSYYSTGICSRVDSNFNFTHSIAPAYQRCETYMDIVIVLDGSNSI 178

  Fly   160 ------------------------------------RAFRIDP---------------------- 166
                                                ..||:|.
Zfish   179 YPWYEVQDFLINVLQKFYIGPGQIQVGVVQYGERVVNEFRLDDFRTVDEVVAAAKNIDQRGGEET 243

  Fly   167 ----------------------------------------------------------------- 166
                                                                             
Zfish   244 RTALGINVARTQAFKHGGRPDAKKVMIVITDGESHDSPDLKAAVEESEKDNITLYGIAVLGYYNR 308

  Fly   167 --------------VGTCFTSHNF----------------EEFYEVSPCRTNNWGYHRQGSCQAG 201
                          :.|....|.|                |:.:.:.....|...:..|.| |||
Zfish   309 RGINPEAFLREIKFIATDPDEHFFSVTDESALKDIVDALGEKIFSLEGTNQNGTAFGLQMS-QAG 372

  Fly   202 FSAAINGNGSRLFIGAPGSWYWQGQTYS-------IPPDAKFPFKPPLYQPFGTGGMASSHDVTR 259
            ||:.|..:|  :.:||.|::.|.|....       |||                   .||:....
Zfish   373 FSSHIVEDG--ILVGAVGAYDWNGAVLKETRHGKVIPP-------------------KSSYMKEF 416

  Fly   260 PENQVFSTSESASVNDDSYLGYSMVTGDFDGDRSEDVAIGMPRGGNLVGRIVV----NRWNMANI 320
            ||.         ..|..:|||| ||:........:....|.|| .|..|::|:    |..|:..:
Zfish   417 PEE---------LKNHGAYLGY-MVSSVVSAHHGQLYVAGAPR-FNHTGKVVIFTLTNSGNLTIL 470

  Fly   321 FNITGRQIGEYFGYSLATSDVDGDGLDD-LLIGAPMYTDPDNVEGKYDVGRVYIL---LQG---- 377
            :::.|:|||.|:|..||..|||.|||.| ||:|||||.    ..| ::.|:|||.   |||
Zfish   471 YSLYGKQIGSYYGSELAPIDVDDDGLTDLLLVGAPMYF----YRG-WEKGKVYIYTVGLQGSFIP 530

  Fly   378 ----GPTEEKRWTTEHIRDGYHSKGRFGLALTTLGDVNGDGYGDFAVGAPYDGPEGRGVVYIFHG 438
                ||       :||..|     .|||.|::.|.|:||||:.:..||||.: ...||.:|:|:|
Zfish   531 DGTLGP-------SEHSHD-----SRFGAAMSALPDLNGDGFSELVVGAPLE-DNHRGAIYLFYG 582

  Fly   439 SPMGPLAKPSQIIKSEQLVEG---APYPRTFGFALSGGLDMDGNTYPDLAVGAYSSDQVFIFKSR 500
                  .|.|...|.:|.:.|   ||..|.||.::.|.:|::|:...||:||::.:  ..:..||
Zfish   583 ------LKNSIQTKYKQRISGIELAPGLRYFGRSVHGMMDLNGDGLVDLSVGSFGA--AVLLWSR 639

  Fly   501 PVAAVNAETSFASNSKLISLDDRSCQLVRDHKKVPCMLLTTCWSYTGRYLPEQLDFDVSWLLDAK 565
            .|..|.....|..:.  |::.::.|  :|..::|.|||.|.|.:.|.|          :.:.|.|
Zfish   640 SVVRVGIGVHFEPSK--INVFNKDC--IRGGREVSCMLATVCLNVTAR----------TPMTDPK 690

  Fly   566 KLLNPRMFFLRDEG--------KNIRNQTIRLNYGQKYCLNETVYLLDKVQDKLTPLEVEARYNL 622
            ::.....|...:.|        ....::.:.|....::| .:..:.:.:|.|...||.......|
Zfish   691 RVALRYSFGFEETGYFPRAVLDSTEESRDVTLRPAAQHC-QQLHFHVHEVTDYTRPLTFTVNVGL 754

  Fly   623 RSSRPLDPMVRHRRSILEPVIDQNREIVLRDAINIQKNCGPDNICEPDLKLKVST---------- 677
                        :|:...||:|......||..:.....|..|:.|.|:|.|:.|:
Zfish   755 ------------QRADEGPVLDDGWPTSLRSELPFWNGCDNDDQCVPNLILQSSSDLLDLREFCS 807

  Fly   678 ----------VDKYLFGSPEPL--------VIEVFISNTNEDAFEAAFYMVTPPDLQFRKLQQLG 724
                      ||:....:||.|        |:|..:.|..|:|:.:..::...|:|.|..| .:.
Zfish   808 RDERSSWPPCVDQSSIKTPERLVESSRRKVVVETHLENRGENAYNSILHITHSPNLHFSSL-VVK 871

  Fly   725 EKKDTPITCSPPTPENNHTLKCDIGNP-LESGKIAHFKISLVPEEKYG--------------SSS 774
            ...|..|.| |.:.:.:....|::..| :.:....:|::    |.::.              ||.
Zfish   872 APSDIAIEC-PNSDDTSLYRTCNVSAPFMRASAQVYFRL----EFEFSRSVFLNYVNISLRVSSE 931

  Fly   775 SYDFYWEANSTNLEKPGSEYDNKIRQSVGIWVDTDLDIKGTSLPDYQLYKADDYKELENATKEDD 839
            ..:.:.|.|..|:.       :.:|                       |:||.....:::....:
Zfish   932 GEEMFPEDNINNIH-------HNLR-----------------------YEADILFTRDSSPSRFE 966

  Fly   840 IGPQVVH------------IYEIRN-------------NRPSIIEEAEVFIHLPYETIVGDPLMY 879
            |.|:..|            .|:|:|             |..::..:|...:||      .|  :|
Zfish   967 IKPEQAHSVSVGSGPPFNLSYQIQNLGLFPVSELLFTLNVFAVTRKANTLLHL------SD--LY 1023

  Fly   880 LLNQP----------ETGGKIQCDDVAFNEY-NLLLDEKLVKKSYLQAQGAIWNSAQVSGQSSSS 933
            :...|          ..|...|.:|::.|.: |....:.|:    .|.:..:...|.|     |.
Zfish  1024 IQQMPGSLCSFPRVITAGSSSQEEDLSLNAHMNASTSDALL----AQCRFNLSPQADV-----SI 1079

  Fly   934 SSSGGASVHIEKARGEGFVRGVLVSNSTDAGDKLSPKQ--------------VEQRRQED----- 979
            :.:|..::|...|  ..|.|..||..:|   .:|||..              :|.|::||
Zfish  1080 TVTGWLNLHTLLA--VKFKRLDLVMTAT---VELSPSNPMFLHEERPMRHIILEIRKEEDYRIPV 1139

  Fly   980 ------TLE----------ALGDASFVHRDRASQAVQE 1001
                  ||.          ||....|.||.:..:..||
Zfish  1140 WVIIGSTLGGLQLLALLVLALWKLGFFHRQKRKRDEQE 1177

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
if	NP_523378.2	Int_alpha	46..110	CDD:214549	16/63 (25%)
		Int_alpha	275..>316	CDD:214549	13/44 (30%)
		Int_alpha	398..451	CDD:214549	21/52 (40%)
		Int_alpha	466..>497	CDD:214549	9/30 (30%)
		Integrin_alpha2	500..892	CDD:462478	84/477 (18%)
		Glutenin_hmw	<1121..1216	CDD:367362
itga11b	XP_695559.9	None