DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment if and itga6a

DIOPT Version :9

Sequence 1:	NP_001162777.1	Gene:	if / 32661	FlyBaseID:	FBgn0001250	Length:	1396	Species:	Drosophila melanogaster
Sequence 2:	XP_005167466.1	Gene:	itga6a / 503893	ZFINID:	ZDB-GENE-050309-23	Length:	1092	Species:	Danio rerio

Alignment Length:	1462	Identity:	319/1462 - (21%)
Similarity:	526/1462 - (35%)	Gaps:	506/1462 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 LIAMSAHGYNIDLPSYVRFRQSSNSMFGFSIAMHKGRSGFYGNQNNVSLIVGAPKFDTSRYQQGV 88
            |:..||..:|:|..:.:|......|:||||||:|:...    ..:...|::|||| ..:...||.
Zfish    18 LVWTSASAFNLDTQNVLRKSGQPGSLFGFSIALHRQLQ----PHDKTILLIGAPK-ARALSNQGA 77

  Fly    89 TEAGGVFKCSL--NDDDCKLVPFDSKGNNRNVDKEVVDRKSYQWLGATVATGRDSDLVVACAPRY 151
            ...||::.|.:  :.:||..|.||:     :||.. |:.|..||:|.||.:......:|.||.||
Zfish    78 NVTGGLYSCDITTHPNDCSRVDFDN-----DVDVR-VENKENQWMGVTVQSQGPGGKIVTCAHRY 136

  Fly   152 --VFHTMTPSRAFRIDPVGTCFTSHNFEEFYEVSPCRTNNW--------GYHRQGSCQAGFSAAI 206
              :....||..|  .|..|.|:...........|.....||        |:.|.|:||.|.:|..
Zfish   137 QRLLFPNTPQEA--RDITGRCYMLSQDLSIDNQSDEDGGNWKFCDGRTRGHERFGACQQGLAATF 199

  Fly   207 NGNGSRLFIGAPGSWYWQGQTYSIPPDAKFPFKPPLYQ--PFGTGGMASSHDVTRPENQVFSTSE 269
            ..:...:..||||::.|:| ...|........:..|:.  |:..|          .||::  ...
Zfish   200 TKDYHYVIFGAPGAYNWKG-IVRIEQKNNTLLEMGLFDDGPYEVG----------DENRL--DPN 251

  Fly   270 SASVNDDSYLGYSMVTGDFDGDRSEDVAI-GMPRGGNLVGRIVVNR--WNMANIFN----ITGRQ 327
            ...|..:||||:|:.:|....::.:.:.: |.|| .|..|.:|..|  ..::::..    :.|..
Zfish   252 LVPVPANSYLGFSLDSGHSITEKGKLIIVSGAPR-ANHSGAVVFLRKEGELSSMLTPEHILEGPG 315

  Fly   328 IGEYFGYSLATSDVDGDGLDDLLIGAPMYTDPDNVEGKYDVGRVYILLQGGPTEEKRW-TTEHIR 391
            :...|||.:|..|::|||..|:::|||.:...|...|    |.||:.:    .:..|| ....:|
Zfish   316 LASSFGYDVAVVDLNGDGWQDVVVGAPQFFQRDEEVG----GAVYVYI----NKAGRWRDVTPVR 372

  Fly   392 DGYHSKGRFGLALTTLGDVNGDGYGDFAVGAPYDGPEGRGVVYIFHGSPMGPLAKPSQIIKSEQL 456
            ........|||::..:||||.|.:.|.|||||| ...|.|.|||:|||..|...||:||::.:|
Zfish   373 LNGTKDSMFGLSVENIGDVNLDSFEDIAVGAPY-ADSGFGSVYIYHGSADGISTKPAQILEGKQ- 435

  Fly   457 VEGAPYPRTFGFALSGGLDMDGNTYPDLAVGAYSSDQVFIFKSRPVAAVNAETSFASNSKLISLD 521
                ...:.||::|:|.:|:|.|:|||||||:. ||.|||::|:.|.::..:...  ..|.|.|.
Zfish   436 ----HNTKMFGYSLAGNMDLDHNSYPDLAVGSL-SDTVFIYRSKNVISIKKDIKV--TPKEIDLT 493

  Fly   522 DRSCQLVRDHKKVPCMLLTTCWSYTGR---YLPE---QLDFDVSWLLDAKKL-LNPRMFFLRDEG 579
            .::|      ....|:.:..|:||...   |.|:   ...|:..|.  .:|| |..|:.||   .
Zfish   494 KKTC------GNSICLTVEACFSYRANPTTYNPKITISCTFEAEWY--RRKLGLPSRVVFL---D 547

  Fly   580 KNIRNQ------TIRLNYGQ--KYCLNETVYLLDKVQDKLTPLEVEARYNLRSSRPLDPMVRHRR 636
            |...:|      |:.|. ||  |.|....:.|.|.::|||..:.:|....::|::      |.:|
Zfish   548 KTEIDQDYQSTGTLELR-GQNKKACYKTKLRLQDGIRDKLRAIPIEVSVAIQSAK------RGKR 605

  Fly   637 SI----LEPVIDQ---NREIVLRDAINIQKNCGPDNICEPDLKLKVSTVDKYLF----------- 683
            ..    |.|::|.   |:  .|.:...:::.||.||||:.:|.|      :|.|
Zfish   606 QSSLPQLVPILDSTVPNK--TLTEVNFLKEGCGTDNICQSNLNL------QYRFCYRESKQDIFP 662

  Fly   684 ------GSP-------EPLVIEVFISNTN-EDAFEAAFYMVTPPDLQFRKLQQLGEKKDTPITCS 734
                  |.|       :.:.:||.:.|.| :||.||.........|.:...:.| ...|..:.|:
Zfish   663 PLPLENGVPVISLSDQKDIALEVTVRNRNGDDAHEAKLVSHFDDSLSYSGFRSL-RTNDKHVICA 726

  Fly   735 PPTPENNHTLKCDIGNPLESGKIAHF-------KISLVPEEKYGSSSSYDFYWEANSTNLEKPGS 792
              ..:|.....|::|||.:......|       ||||..:|     ...|...|..|:      .
Zfish   727 --ANQNGSLADCELGNPFKRDSEVTFYIILSTGKISLETKE-----VEIDLQLETTSS------Q 778

  Fly   793 EYDNKIRQSVGIWVDTDLDIKGTSLPDYQLYKADDYKELENATKEDDIGPQVVHIYEIRN-NRP- 855
            |..:|::....:.::..|.::|.:.|. |:|...:.|.:....||:::|..:.:.:.:.| .:|
Zfish   779 EGLSKVKAKAKVVIELLLSVQGVAKPS-QVYFGGEVKGMSAMKKEEEVGSLIEYEFRVINLGKPL 842

  Fly   856 SIIEEAEVFIHLPYETIVGDPLMYLLNQPETGGKIQCDDVAFNEYNLLLDEKLVKKSYLQAQGAI 920
            .....|.:.|..|.|:.||..|:||:       ||...|:           :||
Zfish   843 KSFGTASLNIQWPKESSVGKWLLYLM-------KINTRDL-----------QLV----------- 878

  Fly   921 WNSAQVSGQSSSSSSSGGASVHIEKARGEGFVRGVLVSNSTDAGDKLSPKQVEQRRQEDTLEALG 985
                         :.|....::..|.|.:..:|              ..:::|:||..:
Zfish   879 -------------TCSPEREINPLKLREDSSIR--------------KKRELEERRPSE------ 910

  Fly   986 DASFVHRDRASQAVQEPQVNQTSFTTYSTSSSSSGSGAPSAQLRGHSTQGHIQMAGPVQHTSSSS 1050

Zfish   911 ----------------------------------------------------------------- 910

  Fly  1051 SSNYRSWPAQQQQQHQQLLLAGSGGSGLGSPVT-FNDKSQFGGRNNNFHTGTLDLGTLNRGNVDN 1114
                                        |:.:: |.||
Zfish   911 ----------------------------GNKISLFTDK--------------------------- 920

  Fly  1115 ELYRSQGQYQNPSQSLGQSQGQFQANANQGHYQGQNQAQFQARNPGFQGQTSYQGQTQYSGQPGG 1179

Zfish   921 ----------------------------------------------------------------- 920

  Fly  1180 YQTHHVTYSSGSKPYYGRENEDFYDEDNLQQATPGHWSSSSSSSSSSGTRRLRRSNDKDGATEKP 1244
             :.|.:...||
Zfish   921 -RKHKILSCSG------------------------------------------------------ 930

  Fly  1245 LQIDLNSPCQSARCKSIRCVVTNLGTEDGDAAFVAIRARMVAKT-MEKLASNVPLNVSTLAVANV 1308
                      .|||..|:|.:..|.:    .|.:.:::|:...| :|..||...|::...|..::
Zfish   931 ----------DARCVEIKCPLQGLDS----TAVIVLKSRLWNSTFLEDFASYNYLDIIVKASISL 981

  Fly  1309 TLLPFIGAPKDAIVKTHE------IFYKAEPEPLQVP-DVVPLWVVVLAACAGALIFLLLVWLLY 1366
            .:     :.|:.::|..|      :|    ||....| ..||.|::::|..||.|:..|||.||:
Zfish   982 DV-----SAKNIVLKNPETQVRLTVF----PETTATPFGGVPWWIILVAVLAGILMLALLVLLLW 1037

  Fly  1367 KCGFFNRNR-----PTDHS----QERQPLRNG 1389
            |||||.|::     |..|:    :|.:.|::|
Zfish  1038 KCGFFKRSKYEDSVPKYHAVRIRKETRLLKDG 1069

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
if	NP_001162777.1	Int_alpha	46..110	CDD:214549	21/65 (32%)
		Int_alpha	275..>316	CDD:214549	13/43 (30%)
		Int_alpha	398..451	CDD:214549	27/52 (52%)
		Int_alpha	466..>497	CDD:214549	18/30 (60%)
		Integrin_alpha2	499..893	CDD:285619	104/449 (23%)
		DUF2756	<1120..1178	CDD:298627	0/57 (0%)
itga6a	XP_005167466.1	Int_alpha	40..101	CDD:214549	21/65 (32%)
		Int_alpha	257..>293	CDD:214549	11/36 (31%)
		Int_alpha	318..368	CDD:214549	19/57 (33%)
		Int_alpha	378..431	CDD:214549	27/53 (51%)
		Int_alpha	440..>463	CDD:214549	13/22 (59%)
		Integrin_alpha2	476..939	CDD:285619	124/817 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574993
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D325432at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.750